The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study

INTRODUCTION: The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies. METHODS: Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage. RESULTS: Forty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. DISCUSSION: Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join

Loss of [H-3]4-DAMP binding to muscarinic receptors in the orbitofrontal cortex of Alzheimer's disease patients with psychosis

10.1007/s00213-008-1124-9PSYCHOPHARMACOLOGY1982251-259GERMAN

Reduced serotonin 5-HT1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer disease

10.1016/S0006-8993(03)02554-XBRAIN RESEARCH9741-Feb82-87NETHERLAND

Psychosis of Alzheimer's disease is associated with elevated muscarinic M-2 binding in the cortex

10.1212/wnl.57.5.805NEUROLOGY575805-811United State

Postmortem serotoninergic correlates of cognitive decline in Alzheimer's disease

10.1097/00001756-200207020-00021NEUROREPORT1391175-1178United State

Serotonin transporters are preserved in the neocortex of anxious Alzheimer's disease patients

10.1097/01.wnr.0000077546.91466.a8NEUROREPORT14101297-1300NERPEUnited State