The Electrification of Russia, 1880–1926

Russia, 1880–1926 is the first full account of the widespread adoption of electricity in Russia, from the beginning in the 1880s to its early years as a state technology under Soviet rule. Jonathan Coopersmith has mined the archives for both the tsarist and the Soviet periods to examine a crucial element in the modernization of Russia. Coopersmith shows how the Communist Party forged an alliance with engineers to harness the socially transformative power of this science-based enterprise. A centralized plan of electrification triumphed, to the benefit of the Communist Party and the detriment of local governments and the electrical engineers. Coopersmith's narrative of how this came to be elucidates the deep-seated and chronic conflict between the utopianism of Soviet ideology and the reality of Soviet politics and economics

The Electrification of Russia, 1880-1926

≤p≥The Electrification of Russia, 1880–1926 is the first full account of the widespread adoption of electricity in Russia, from the beginning in the 1880s to its early years as a state technology under Soviet rule. Jonathan Coopersmith has mined the archives for both the tsarist and the Soviet periods to examine a crucial element in the modernization of Russia. Coopersmith shows how the Communist Party forged an alliance with engineers to harness the socially transformative power of this science-based enterprise. A centralized plan of electrification triumphed, to the benefit of the Communist Party and the detriment of local governments and the electrical engineers. Coopersmith's narrative of how this came to be elucidates the deep-seated and chronic conflict between the utopianism of Soviet ideology and the reality of Soviet politics and economics.<p

The microbiome restrains melanoma bone growth by promoting intestinal NK and Th1 cell homing to bone

Bone metastases are frequent complications of malignant melanoma leading to reduced quality of life and significant morbidity. Regulation of immune cells by the gut microbiome influences cancer progression, but the role of the microbiome in tumor growth in bone is unknown. Using intracardiac or intratibial injections of B16-F10 melanoma cells into mice, we showed that gut microbiome depletion by broad-spectrum antibiotics accelerated intraosseous tumor growth and osteolysis. Microbiome depletion blunted melanoma-induced expansion of intestinal NK cells and Th1 cells and their migration from the gut to tumor-bearing bones. Demonstrating the functional relevance of immune cell trafficking from the gut to the bone marrow (BM) in bone metastasis, blockade of S1P-mediated intestinal egress of NK and Th1 cells, or inhibition of their CXCR3/CXCL9-mediated influx into the BM, prevented the expansion of BM NK and Th1 cells and accelerated tumor growth and osteolysis. Using a mouse model, this study revealed mechanisms of microbiota-mediated gut-bone crosstalk that are relevant to the immunological restraint of melanoma metastasis and tumor growth in bone. Microbiome modifications induced by antibiotics might have negative clinical consequences in patients with melanoma

Microfluidic Amperometric Sensor for Analysis of Nitric Oxide in Whole Blood

Standard photolithographic techniques and a nitric oxide (NO) selective xerogel polymer were utilized to fabricate an amperometric NO microfluidic sensor with low background noise and the ability to analyze NO levels in small sample volumes (~250 μL). The sensor exhibited excellent analytical performance in phosphate buffered saline, including a NO sensitivity of 1.4 pA nM−1, a limit of detection (LOD) of 840 pM, and selectivity over nitrite, ascorbic acid, acetaminophen, uric acid, hydrogen sulfide, ammonium, ammonia, and both protonated and deprotonated peroxynitrite (selectivity coefficients of −5.3, −4.2, −4.0, −5.0, −6.0, −5.8, −3.8, −1.5, and −4.0 respectively). To demonstrate the utility of the microfluidic NO sensor for biomedical analysis, the device was used to monitor changes in blood NO levels during the onset of sepsis in a murine pneumonia model

How effective is low vision service provision? A systematic review

Visual impairment is a large and growing socioeconomic problem. Good evidence on rehabilitation outcomes is required to guide service development and improve the lives of people with sight loss. Of the 478 potentially relevant articles identified, only 58 studies met our liberal inclusion criteria, and of these only 7 were randomized controlled trials. Although the literature is sufficient to confirm that rehabilitation services result in improved clinical and functional ability outcomes, the effects on mood, vision-related quality of life (QoL) and health-related QoL are less clear. There are some good data on the performance of particular types of intervention, but almost no useful data about outcomes in children, those of working age, and other groups. There were no reports on cost effectiveness. Overall, the number of well-designed and adequately reported studies is pitifully small; visual rehabilitation research needs higher quality research. We highlight study design and reporting considerations and suggest a future research agenda

Failure & Technology

Coopersmith, Jonathan. "Failure and Technology." Japan Journal for Science, Technology and Society 18 (2009): 93–118.Failure is an integral and normal part of a technology's evolution. Widely viewed, failure extends from the commercial collapse of a firm promoting new technology and the inability of a technology to profit in the marketplace to less obvious shortcomings like suboptimal performance, poor economics, and late delivery. Historians have not paid sufficient attention to this important subject, focusing on success. The understandable tendency to focus on what worked instead on what did not has resulted in a simplified appreciation of the tortuous, demanding and uncertain path that technologies follow to move from an idea to a reality. This paper explores the importance of failure in the history of technology and offers a theoretical framework to approach failure

Setting the Stage: Government-Industry Creation of the Japanese Fax Industry

Discusses the significance of the Japanese government’s role in the development of fax technology as a good model of how governments can influence the agents shaping technology. Describes how the Japanese government’s push on domestic fax manufacturers and telephone companies in the 1970s to create a common standard lead to the fax boom of the 1980s.Japan Industry and Management of Technology (JIMT) ProgramIC2 Institut

Failure & Technology

Coopersmith, Jonathan. "Failure and Technology." Japan Journal for Science, Technology and Society 18 (2009): 93–118.Failure is an integral and normal part of a technology's evolution. Widely viewed, failure extends from the commercial collapse of a firm promoting new technology and the inability of a technology to profit in the marketplace to less obvious shortcomings like suboptimal performance, poor economics, and late delivery. Historians have not paid sufficient attention to this important subject, focusing on success. The understandable tendency to focus on what worked instead on what did not has resulted in a simplified appreciation of the tortuous, demanding and uncertain path that technologies follow to move from an idea to a reality. This paper explores the importance of failure in the history of technology and offers a theoretical framework to approach failure