Sobre la desaparición de la correlación de sonoridad en castellano

En este número no se incluyeron resúmenes ni palabras clave

CYP1A1 Variability In Human Populations

The human cytochrome P4501A1 (CYP1A1) enzyme plays an important role in the metabolism of xenobiotics and endogenous substrates. Because polymorphisms within the CYP1A1 gene have been shown to be associated with various cancer risks and with the predicting clinical efficacy of some chemotherapies in different populations, most studies focus on their clinical significance. We, however, were interested in evaluating whether the polymorphisms could be used to distinguish human populations. Four single nucleotide CYP1A1 polymorphisms (rs4646903/ g.75011641; rs1048943/g.75012985; g.75012235; and rs1799814/ g.75012987) were analysed via PCR-RFLP assay in 1,195 individuals of various human groups from all over the world. In order to gain a more complete view of the genetic variability of the CYP1A1 gene, different statistical analyses were performed upon the populations of the present study and upon the limited data gleaned from previously studied populations. The allele and haplotype frequencies vary among populations: the rs4646903 (C) and rs1048943 (G) have been found to be nearly always linked and were found at the highest frequencies in Native Americans, while the variant associated to the position g.75012235 was only detected in certain African populations. Our work clearly indicates that the CYP1A1 polymorphisms differ among populations and that the prediction of genotypes constitutes an important aspect of precision medicine since some variants were associated with certain cancers and rs1048943 show strong association with optimized chemotherapy. Moreover, the CYP1A1 gene plays an important role in the metabolism of xenobiotics and it is likely that its frequencies could be strongly influenced by environmental factors

À propos de tribu martel

Contini Gianfranco. À propos de tribu martel. In: Romania, tome 63 n°250, 1937. pp. 253-266

Sept poésies lyriques du troubadour Bertrand Carbonel de Marseille (Suite et fin)

Contini Gianfranco. Sept poésies lyriques du troubadour Bertrand Carbonel de Marseille (Suite et fin). In: Annales du Midi : revue archéologique, historique et philologique de la France méridionale, Tome 49, N°195, 1937. pp. 225-240

Alfredo Schiaffini, Tradizione e poesia nella prosa d'arte italiana dalla latinità médiévale a G. Boccaccio, 1934

Contini Gianfranco. Alfredo Schiaffini, Tradizione e poesia nella prosa d'arte italiana dalla latinità médiévale a G. Boccaccio, 1934. In: Romania, tome 62 n°245, 1936. pp. 119-121

Sept poésies lyriques du troubadour Bertrand Carbonel de Marseille

Contini Gianfranco. Sept poésies lyriques du troubadour Bertrand Carbonel de Marseille. In: Annales du Midi : revue archéologique, historique et philologique de la France méridionale, Tome 49, N°193, 1937. pp. 5-41

Encore à propos de Bertrand Carbonel

Contini Gianfranco. Encore à propos de Bertrand Carbonel. In: Annales du Midi : revue archéologique, historique et philologique de la France méridionale, Tome 51, N°202, 1939. pp. 191-194

Alfredo Schiaffini, Tradizione e poesia nella prosa d'arte italiana dalla latinità médiévale a G. Boccaccio, 1934

Contini Gianfranco. Alfredo Schiaffini, Tradizione e poesia nella prosa d'arte italiana dalla latinità médiévale a G. Boccaccio, 1934. In: Romania, tome 62 n°245, 1936. pp. 119-121