9 research outputs found
Cyanidin-3-glucoside prevents hydrogen peroxide (H2O2)-induced oxidative damage in HepG2 cells
Isoliquiritigenin prevents hyperglycemia-induced renal injuries by inhibiting inflammation and oxidative stress via SIRT1-dependent mechanism
Advanced glycation end products accelerate calcification in VSMCs through HIF-1伪/PDK4 activation and suppress glucose metabolism
蔚2 allele and 蔚2-involved genotypes (蔚2/蔚2, 蔚2/蔚3, and 蔚2/蔚4) may confer the association of APOE genetic polymorphism with risks of nephropathy in type 2 diabetes: a meta-analysis
PHLPP1/Nrf2鈥揗dm2 axis induces renal apoptosis via influencing nucleo-cytoplasmic shuttling of FoxO1 during diabetic nephropathy
Reversible histone glycation is associated with disease-related changes in chromatin architecture
Molecular mechanisms of methylglyoxal-induced aortic endothelial dysfunction in human vascular endothelial cells
Effect of Tungstate Administration on the Lipid Peroxidation and Antioxidant Parameters in Salivary Glands of STZ-Induced Diabetic Rats
Natural polyphenols as modulators of the fibrillization of islet amyloid polypeptide
Diabetes mellitus type 2 (type-2 diabetes) is a metabolic disorder characterized by the increased blood glucose concentration and insulin resistance in peripheral tissues (e.g., muscles and adipose tissue). The initiation of the pathological cascade of events that lead to type-2 diabetes has been subject of debate; however, it has been commonly accepted that the oversecretion of human islet amyloid polypeptide (hIAPP, a hormone co-secreted with insulin) by the pancreaticThe authors acknowledge the finan-cial support from the European Commission鈥檚 H2020 pro-gram, under grant agreements H2020-WIDESPREAD-2014-668983-FORECAST and H2020-WIDESPREAD-01-2016-2017-739572-THE DISCOVERIES CTR.ARA acknowledges Norte2020, NORTE-08-5369-FSE-000037, for her PhD grant