17 research outputs found

    In preterm infants, ascending intrauterine infection is associated with lower cerebral tissue oxygen saturation and higher oxygen extraction

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    BACKGROUND: Placental lesions are associated with neurological morbidity but the mechanism leading to morbidity is unclear. To provide insight into such a possible mechanism, we determined whether placental lesions were associated with regional cerebral tissue oxygen saturation (r(c)SO(2)) and fractional tissue oxygen extraction (FTOE) in preterm infants during their first 5 d after birth. We hypothesized that as a result of cerebral hypoperfusion, rcSO2 would be lower and FTOE would be higher. METHOD: In a prospective, observational study of 42 preterm infants (gestational age RESULTS: Only three placentas showed no pathology. Ascending intrauterine infection (AlUI) (n = 16) was associated with lower r(c)SO(2) and higher FTOE values on days 2, 3, and 4 (P CONCLUSION: AlUI is associated with lower r(c)SO(2), and higher FTOE shortly after birth. The effect it has on cerebral oxygenation might be the mechanism leading to neurodevelopmental problems
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