Autistic behavior in boys with fragile X syndrome: social approach and HPA-axis dysfunction

The primary goal of this study was to examine environmental and neuroendocrine factors that convey increased risk for elevated autistic behavior in boys with Fragile X syndrome (FXS). This study involves three related analyses: (1) examination of multiple dimensions of social approach behaviors and how they vary over time, (2) investigation of mean levels and modulation of salivary cortisol levels in response to social interaction, and (3) examination of the relationship of social approach and autistic behaviors to salivary cortisol. Poor social approach and elevated baseline and regulation cortisol are discernible traits that distinguish boys with FXS and ASD from boys with FXS only and from typically developing boys. In addition, blunted cortisol change is associated with increased severity of autistic behaviors only within the FXS and ASD group. Boys with FXS and ASD have distinct behavioral and neuroendocrine profiles that differentiate them from those with FXS alone and typically developing boys

Altered stress responses in children exposed to early adversity: A systematic review of salivary cortisol studies.

Pathological stress responses are implicated in numerous disorders. Hypothalamic-pituitary-adrenal axis function is influenced by gene-environment interaction, with early-life environmental adversity having long-lasting effects. We examine the evidence that, in humans, these effects are apparent from infancy. We systematically reviewed published findings on cortisol response to a stressor, in 0-5-year-olds already exposed to adversity. Adversity was defined as a negative environmental influence present post-conception. We searched Ovid MEDLINE (1950-May 2010), EMBASE (1980-May 2010) and PsychINFO (1806-May 2010). We included peer-reviewed, English language studies that analysed salivary cortisol before and after a standardised stressor. We identified 30 studies, of which 27 reported a significant effect of adversity on the cortisol response to stress. Six of these demonstrated an effect of prenatal substance exposure. Thirteen studies found that psychosocial adversity increased cortisol reactivity. Three studies reported that cortisol reactivity could be normalised by intervention programmes. The studies were heterogeneous, both in nature of adversity studied and in stressor used, precluding meta-analysis and assessment of publication bias. Our review presents evidence that adversity disrupts the stress response from an early age. Longitudinal studies are required to determine whether effects persist, alter with time, or are reversible with intervention

Psychometric properties of the Italian adaptation of the Mor Barak et al. diversity climate scale

The Diversity Climate Scale is a questionnaire developed in the U.S. for the investigation of employees\u2019 shared perceptions about their organizational context related to women and minorities. The measure was not used in the European context yet. The psychometric properties of the Italian adaptation of the Mor Barak, Cherin and Berkman Diversity Climate Scale were investigated in this work by using a sample of Italian (n = 395) white-collar and blue-collar employees. A pilot study to make the scale suitable for the Italian context was conducted using the cognitive interview technique. Then a series of multiple-group confirmatory factor analyses was performed. The results showed that a three-factor solution best fit the data, using only 12 items of the original scale. The analyses supported factor variance and factor covariance equivalence in addition to metric equivalence. Internal consistency of the scale was good. Discriminant validity between latent factors and Criterion validity were supported