Clinical investigation of Class V GIC restorations: 18 months results

published_or_final_versio

Quality management standards, institutionalization and organizational implications : a longitudinal analysis

2017-2018 > Academic research: refereed > Publication in refereed journal201812 bcrcAccepted ManuscriptRGCPolyU 5518/10HPublishe

Hepatitis B virus-specific immune response after liver transplantation

Abstrac

Cross-sectional study on hepatitis B virus-specific CD4+ T cell immune response after liver transplantation

Background/Aims: Hepatitis B virus (HBV)-specific T cells play a critical role in controlling viralreplication and maintaining the protective immunity against HBV reinfection. In this study, wecharacterized HBV-specific CD4+ T cell-mediated immune response after liver transplantation forHBV-associated liver disease.Methods: The function and frequency of circulating HBV-specific CD4+ T cells were studied byproliferation and enzyme-linked immunospot assays in 40 recipients without evidence of HBVrecurrence at 1 year (n=29) or at 5 years (n=11) after liver transplantation, and in 6 recipients withrecurrent HBV infection.Results: T cell proliferation response to mitogen (phytohemagglutinin) and recall antigen (tetanustoxoid) were maintained in recipients at 1 and 5 years after transplantation, comparable to those ofpre-transplant patients and healthy subjects, however, HBV-specific CD4+ T cell proliferationresponse and frequency significantly declined to either undetectable or very low levels. In recipientswith HBV recurrence, despite immunosuppression, a significant HBV-specific CD4+ T cell responsewas detectable, but did not correlate with viral load, histology and levels of liver transaminases.Conclusions: HBV-specific CD4+ T cell immune responses may evanesce with clearance of viralantigens after liver transplantation, suggesting the necessity of retaining a long-term prophylactictreatment or developing new strategies to induce HBV-specific immunity for prevention of HBVrecurrence.Figure The median levels of T cell proliferation (a) and median frequencies of interferon (IFN)-γ-secreting T cells (b) in response to in vitro challenge with hepatitis B surface (HBsAg) and coreantigen (HBcAg) in 11 HBV-naïve and 23 HBV-immune healthy subjects, 29 HBV-infected patientsbefore liver transplantation (LT), 29 at 1 year post-LT, 11 at 5 years post-LT, as well as 6 recipientswith recurrent HBV infection. * Significantly lower than pre-LT and HBV immune controls, **significantly lower than HBV immune control (P < 0.05, Mann-Whitney U test). Dot lines indicatethe significant level of HBV-specific immune response.link_to_subscribed_fulltex

A citation network analysis of sustainability development in liner shipping management : a review of the literature and policy implications

202304 bckwAccepted ManuscriptSelf-fundedPublishe

Sustainability risk in supply bases : the role of complexity and coupling

202208 bcfcNot applicableOthersThis research was supported by the Specialized Subsidy Scheme for Macao Higher Education Institutions in the Area of Research in Humanities and Social Sciences of the Higher Education Fund, Macau SAR. This research was partly supported by Monash University. The project was supported by the funding by the Hong Kong Polytechnic UniversityPublished36 month

Enhancing economic sustainability by markdown money supply contracts in the fashion industry : China vs U.S.A.

2015-2016 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

The role of information systems in the sustainable development of enterprises : a systematic literature network analysis

202008 bcrcVersion of RecordPublishe