9 research outputs found
Enantioselective, intermolecular benzylic CâH amination catalysed by an engineered iron-haem enzyme
CâH bonds are ubiquitous structural units of organic molecules. Although these bonds are generally considered to be chemically inert, the recent emergence of methods for CâH functionalization promises to transform the way synthetic chemistry is performed. The intermolecular amination of CâH bonds represents a particularly desirable and challenging transformation for which no efficient, highly selective, and renewable catalysts exist. Here we report the directed evolution of an iron-containing enzymatic catalystâbased on a cytochrome P450 monooxygenaseâfor the highly enantioselective intermolecular amination of benzylic CâH bonds. The biocatalyst is capable of up to 1,300 turnovers, exhibits excellent enantioselectivities, and provides access to valuable benzylic amines. Iron complexes are generally poor catalysts for CâH amination: in this catalyst, the enzyme's protein framework confers activity on an otherwise unreactive iron-haem cofactor
Design and engineering of cytochrome P450 systems
Stephen G. Bell, Nicola Hoskins, Christopher J. C. Whitehouse and Luet L. Won
Workâlife programs and performance in Australian organisations: the role of organisation size and industry type
Organisations are increasingly using workâlife programs to strategically manage their workforce in a competitive labour market. Extant research has investigated various outcomes of workâlife programs but has lacked focus on organisational financial performance and context. Drawing on strategic human resource management theory, this study proposes and tests a workâlife programsâperformance relationship. It also investigates the moderating effects of organisation size and industry on the workâlife programsâperformance relationship. We used a time-lagged design and data from multiple sources to link workâlife programs with firm performance in 117 organisations in Australia. The findings support the hypothesis that workâlife programs are positively associated with financial performance. This study also provides pioneering evidence for the moderating effects of organisation size and industry type on the workâlife programsâorganisational performance relationship.</p