Correlation of the movements of the Severn Suspension Bridge derived with GNSS with Temperature Variations.

In March 2010, four days of GNSS data were gathered on the Severn Suspension Bridge. The GNSS antennas were located on the tops of the four support towers, as well as five locations on the suspension cables. The Severn Bridge has a main suspended span of 998m long. The GNSS data were gathered at rates of 10Hz and 20Hz between the 10th to the 12th and on the morning of the 18th March 2010. In addition to the GNSS data, the air and steel temperatures were gathered every 10 minutes. The GNSS data were processed in an On The Fly manner relative to a reference GNSS receiver located on a solid building adjacent to the Bridge

Photocatalytic Oxygen Evolution from Cobalt-Modified Nanocrystalline BiFeO3 Films Grown via Low-Pressure Chemical Vapor Deposition from beta-Diketonate Precursors

BiFeO3 is an interesting multifunctional narrow band gap semiconductor that exhibits simultaneous multiferroic, photovoltaic, and photocatalytic behavior. Hence there is much interest in the growth of thin films of BiFeO3 via chemical vapor deposition (CVD); however, the number of suitable bismuth precursors is severely limited. A series of homoleptic bismuth(III) β-diketonate complexes were synthesized via simple room temperature ligand-exchange reactions from [Bi(N(SiMe3)2)3] and free diketonate ligands, which yielded the crystal structure of [Bi(acac)3] as a 1-D polymer. We attempted to use these complexes for low pressure CVD (LPCVD) growth of BiFeO3 films with [Fe(acac)3]; however, all bismuth complexes exhibited poor volatilities and decomposition characteristics, and as a result film growth was unsuccessful. Subsequently, the volatile alkoxide [Bi(OtBu)3], with [Fe(acac)3], was used to grow dense BiFeO3 films via low pressure CVD. The BiFeO3 films possessed multiferroic properties at room temperature and exhibited activity for visible light-driven water oxidation in the presence of a Ag+ electron scavenger, which improved significantly when modified with a cobalt surface cocatalyst. The increase in activity, probed by time-resolved photoluminescence spectroscopy, was attributed to improved charge carrier separation arising from the in-built internal electric field of BiFeO3 in addition to the presence of an efficient cobalt oxygen evolution catalyst

Stochastic generation of complex crystal structures combining group and graph theory with application to carbon

A method is introduced to stochastically generate crystal structures with defined structural characteristics. Reasonable quotient graphs for symmetric crystals are constructed using a random strategy combined with space group and graph theory. Our algorithm enables the search for large-size and complex crystal structures with a specified connectivity, such as three-fold sp2 carbons, four-fold sp3 carbons, as well as mixed sp2-sp3 carbons. To demonstrate the method we randomly construct initial structures adhering to space groups from No.75 to No.230 and a range of lattice constants, and we identify 281 new sp3 carbon crystals. First-principles optimization of these structures show that most of them are dynamically and mechanically stable and are energetically comparable to those previously proposed. Some of the new structures can be considered as candidates to explain the experimental cold compression of graphite

Visible-light driven water splitting over BiFeO₃ photoanodes grown via the LPCVD reaction of [Bi(OtBu)₃] and [Fe(OtBu)₃]₂ and enhanced with a surface nickel oxygen evolution catalyst

Phase-pure BiFeO3 films were grown directly via dual-source low-pressure CVD (LPCVD) from the ligand-matched precursors [Bi(O(t)Bu)3] and [Fe(O(t)Bu)3]2, without the requirement for oxidising gas or post deposition annealing. Photocatalytic testing for water oxidation revealed extremely high activity for PEC water splitting and photocatalytic water oxidation under visible light irradiation (λ > 420 nm) with a benchmark IPCE for BiFeO3 of 23% at 400 nm. The high activity is ascribed to the ultrafine morphology achieved via the LPCVD process. The performance was enhanced by over four times when the BiFeO3 photoanode is coupled to a Ni-B surface OEC

Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development

published_or_final_versio

Homogeneous catalysis under ultra-dilute conditions: TAML/NaClO oxidation of persistent metaldehyde

This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Journal of the American Chemical Society, copyright © American Chemical Society after peer review. To access the final edited and published work see https://doi.org/10.1021/jacs.6b11145TAML activators enable homogenous oxidation catalysis where the catalyst and substrate (S) are ultra-dilute (pM–low μM) and the oxidant is very dilute (high nM–low mM). Water contamination by exceptionally persistent micropollutants (MPs), including metaldehyde (Met), provides an ideal space for determining the characteristics and utilitarian limits of this ultradilute catalysis. The low MP concentrations decrease throughout catalysis with S oxidation (kII) and catalyst inactivation (ki) competing for the active catalyst. The percentage of substrate converted (%Cvn) can be increased by discovering methods to increase kII/ki. Here we show that NaClO extends catalyst lifetime to increase the Met turnover number (TON) threefold compared with H2O2, highlighting the importance of oxidant choice as a design tool in TAML systems. Met oxidation studies (pH 7, D2O, 0.01 M phosphate, 25 °C) monitored by 1H NMR spectroscopy show benign acetic acid as the only significant product. Analysis of TAML/NaClO treated Met solutions employing successive identical catalyst doses revealed that the processes can be modeled by the recently published relationship between the initial and final [S] (S0 and S∞, respectively), the initial [catalyst] (FeTot) and kII/ki. Consequently, this study establishes that S is proportional to S0 and that the %Cvn is conserved across all catalyst doses in multicatalyst-dose processes because the rate of the kII process depends on [S] while that of the ki process does not. A general tool for determining the FeTot required to effect a desired %Cvn is presented. Examination of the dependence of TON on kII/ki and FeTot at a fixed S0 indicates that for any TAML process employing FeTot < 1 10-6 M, small catalyst doses are not more efficient than one large dose.T.J.C thanks the Heinz Endowments for funding. NMR instrumentation at CMU was partially supported by NSF (CHE-0130903 and CHE-1039870)

There are three major Neisseria gonorrhoeae β-lactamase plasmid variants which are associated with specific lineages and carry distinct TEM alleles

Neisseria gonorrhoeae is a significant threat to global health with an estimated incidence of over 80 million cases each year and high levels of antimicrobial resistance. The gonococcal β-lactamase plasmid, pbla, carries the TEM β-lactamase, which requires only one or two amino acid changes to become an extended-spectrum β-lactamase (ESBL); this would render last resort treatments for gonorrhoea ineffective. Although pbla is not mobile, it can be transferred by the conjugative plasmid, pConj, found in N. gonorrhoeae. Seven variants of pbla have been described previously, but little is known about their frequency or distribution in the gonococcal population. We characterised sequences of pbla variants and devised a typing scheme, Ng_pblaST that allows their identification from whole genome short-read sequences. We implemented Ng_pblaST to assess the distribution of pbla variants in 15 532 gonococcal isolates. This demonstrated that only three pbla variants commonly circulate in gonococci, which together account for >99 % of sequences. The pbla variants carry different TEM alleles and are prevalent in distinct gonococcal lineages. Analysis of 2758 pbla-containing isolates revealed the co-occurrence of pbla with certain pConj types, indicating co-operativity between pbla and pConj variants in the spread of plasmid-mediated AMR in N. gonorrhoeae. Understanding the variation and distribution of pbla is essential for monitoring and predicting the spread of plasmid-mediated β-lactam resistance in N. gonorrhoeae

On the stability of fissured slopes subject to seismic action

A set of analytical solutions achieved by the upper bound theorem of limit analysis and the pseudo-static approach is presented for the assessment of the stability of homogeneous c, ϕ slopes manifesting vertical cracks and subject to seismic action. Rotational failure mechanisms are considered for slopes with cracks of either known or unknown depth and location. A validation exercise was carried out based on numerical limit analyses and displacement-based finite-element analyses with strength reduction technique. Charts providing the stability factor for fissured slopes subject to both horizontal and vertical accelerations for any combination of c, ϕ and slope inclination are provided. The effect of the direction of the vertical acceleration on slope stability is specifically analysed. Yield seismic coefficients are also provided. When the presence of cracks within the slope can be ascertained with reasonable confidence, maps showing the zones within the slope where they have no destabilising effect are provided. Finally, Newmark's method was employed to assess the effect of cracks on earthquake induced displacements. To this end, displacement coefficients are provided in chart form as a function of the slope characteristics. Two examples of slopes subjected to known earthquakes are illustrated