16 research outputs found
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
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- The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
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- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Cancer Biomarker Discovery: The Entropic Hallmark
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- A Arabzadeh
- A Bagri
- A Balbin
- A Bantis
- A Ben-Naim
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- A Geirsson
- A Geirsson
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- A Inoue
- A Isidoro
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- A Marreiros
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- A Nassar
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- A Petitjean
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- E Beitz
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- HC Lee
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- I Agalliu
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- IE Wertz
- IK Lim
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- J Edwards
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- JT Chang
- JW Denham
- K Armstrong
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- K Ishitani
- K Kami
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- K Kumagai
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- LP Kunju
- M Aalamian-Matheis
- M Aghaei
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- M Boury-Jamot
- M Boury-Jamot
- M Buxade
- M Chellaiah
- M Cimitan
- M Craig
- M Dumas
- M Dundr
- M Esteller
- M Estler
- M Fabbri
- M Fukunaga-Kalabis
- M Fukunaga-Kalabis
- M Furuno
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- M Hatzfeld
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- M Tischkowitz
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- M Yang
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- M Zhou
- M Zhou
- M Zhou
- MA Castro
- MA Chekmareva
- MA Chellaiah
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- MY Lee
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- N Singh
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- NJ Fisch
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- O Bettendorf
- O Canbolat
- O Itzhaki
- O Kwon
- OA Rosso
- OW Rokhlin
- P Agre
- P Agre
- P Agre
- P Agre
- P Allavena
- P Berthon
- P Boukamp
- P Cossu-Rocca
- P Dhawan
- P Dhawan
- P Duesberg
- P Duesberg
- P Duesberg
- P Hainaut
- P Ji
- P Karakiewicz
- P Koivisto
- P Roy-Burman
- P Rustin
- P Sini
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- P Sotomayor
- P Sotomayor
- P Steigemann
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- R Dobson
- R Halaban
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- R Klimek
- R Klimek
- R Kuefer
- R Lin
- R Mazzucchelli
- R Mukherjee
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- R Rai
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- S Ashida
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- SV Setzer
- T Dalmay
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- T Kusumi
- T Litman
- T Ma
- T Mirtti
- T Murakami
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- T Sun
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- T Takeda
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- T Yu
- TB Lewis
- TD Prickett
- TH Ecke
- TJ McDonnell
- TJ Park
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- TO Nielsen
- TR Mercer
- U Brinck
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- UV Wesley
- V Ambros
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- V Fradet
- V Molinie
- V Molinie
- V Molinie
- V Molinie
- V Molinie
- V Molinie
- V Pekovic
- V Rajaram
- V Samanna
- V Wessagowit
- V Winnepenninckx
- VD Acevedo
- VK Vanguri
- VL Verstraeten
- W Chen
- W Cosme-Blanco
- W Gade
- W Ritchie
- W Spirkl
- W Tettelbach
- W Wang
- W Weichert
- W Weichert
- W Weichert
- WB Isaacs
- WD Dunsmuir
- WE Naugler
- William C. S. Cho
- WK Kaufmann
- WK Lee
- X Chen
- X Cheng
- X Dong
- X Dong
- X Huang
- X Li
- X Liu
- X Liu
- X Meng
- X Ouyang
- X Tang
- X Wu
- X Zhang
- XJ Yang
- XQ Wang
- Y Bu
- Y Cai
- Y Deng
- Y Ito
- Y Katagiri
- Y Kozuka
- Y Lai
- Y Liu
- Y Lu
- Y Lu
- Y Ohyama
- Y Shav-Tal
- Y Sugiyama
- Y Sun
- Y Wang
- Y Wang
- Y Wu
- Y Yamamoto
- Y Yang
- Y Zhou
- YB Lim
- YC Chao
- YJ Ko
- YL Liu
- YN Liu
- YT Sasaki
- YT Sasaki
- YU Katagiri
- Z Jiang
- Z Jiang
- Z Jiang
- Z Jiang
- Z Jiang
- Z Rudzki
- ZA Dotan
- ZR Yurkovetsky
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Background: It is a commonly accepted belief that cancer cells modify their transcriptional state during the progression of the disease. We propose that the progression of cancer cells towards malignant phenotypes can be efficiently tracked using high-throughput technologies that follow the gradual changes observed in the gene expression profiles by employing Shannon's mathematical theory of communication. Methods based on Information Theory can then quantify the divergence of cancer cells' transcriptional profiles from those of normally appearing cells of the originating tissues. The relevance of the proposed methods can be evaluated using microarray datasets available in the public domain but the method is in principle applicable to other high-throughput methods. Methodology/Principal Findings: Using melanoma and prostate cancer datasets we illustrate how it is possible to employ Shannon Entropy and the Jensen-Shannon divergence to trace the transcriptional changes progression of the disease. We establish how the variations of these two measures correlate with established biomarkers of cancer progression. The Information Theory measures allow us to identify novel biomarkers for both progressive and relatively more sudden transcriptional changes leading to malignant phenotypes. At the same time, the methodology was able to validate a large number of genes and processes that seem to be implicated in the progression of melanoma and prostate cancer. Conclusions/Significance: We thus present a quantitative guiding rule, a new unifying hallmark of cancer: the cancer cell's transcriptome changes lead to measurable observed transitions of Normalized Shannon Entropy values (as measured by high-throughput technologies). At the same time, tumor cells increment their divergence from the normal tissue profile increasing their disorder via creation of states that we might not directly measure. This unifying hallmark allows, via the the Jensen-Shannon divergence, to identify the arrow of time of the processes from the gene expression profiles, and helps to map the phenotypical and molecular hallmarks of specific cancer subtypes. The deep mathematical basis of the approach allows us to suggest that this principle is, hopefully, of general applicability for other diseases
The management of chronic prostatitis in men with HIV
- Author
- A Mehik
- CF Heyns
- CJ Kay
- D Dikov
- DA Shoskes
- DA Shoskes
- DJ Kwan
- EL Murphy
- FC Lowe
- Franklin C. Lowe
- G Hyun
- GM Habermacher
- HY Marans
- JC Nickel
- JC Nickel
- JC Nickel
- JC Nickel
- JC Nickel
- JC Nickel
- JC Nickel
- JC Nickel
- JC Nickel
- JR Adams
- K Bertschinger
- K Bertschinger
- LK Lee
- M McNaughton Collins
- MM Collins
- P Oliveira
- PJ Benson
- PY Cheah
- RB Alexander
- SA Kaplan
- SJ Trauzzi
- SV Hood
- TE Bjerklund Johansen
- Vincent M. Santillo
- VR Staiman
- VR Staiman
- VR Staiman
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The DABBEC Phenotyping System: towards a mechanistic understanding of CP/CPPS
- Author
- A Katsnelson
- A Kuchinad
- A Latremoliere
- A Patapoutian
- AJ Schaeffer
- BL Ganzel
- BS McEwen
- C Patte-Mensah
- C Savoye-Collet
- CJ Woolf
- DA Shoskes
- DA Shoskes
- Derek J. Erstad
- DG Finniss
- EA Calhoun
- F Benedetti
- H Cohen
- I Tegeder
- J Dimitrakov
- J Nickel
- J Scholz
- JC Nickel
- JC Nickel
- JC Nickel
- JC Nickel
- Jeffrey M. Cohen
- JN Krieger
- Jordan D. Dimitrakoff
- Karolina Brook
- KJ Propert
- L Colloca
- M Costigan
- M McNaughton Collins
- MA Pontari
- MA Rodriguez
- MM Collins
- MS Litwin
- P Dunckley
- PJ Siddall
- RB Alexander
- RB D'Agostino Sr.
- RU Anderson
- S Nimkarn
- Salman F. Bhai
- SE Ross
- SK Lutgendorf
- Stephen A. Allsop
- T Schmidt-Wilcke
- TE Bjerklund Johansen
- V Schaeffer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Is there a role for minimally invasive thermotherapy for the treatment of chronic prostatitis?
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Assessing chronic pelvic pain syndrome patients: Blood plasma factors and cortisol saliva
- Author
- Aghazarian A
- Alexander RB
- Aloisi AM
- Anderson RU
- Blanco LE
- Clemens JQ
- Dantzer R
- Desireddi NV
- Dimitrakov J
- Duan Z-G
- Grieb G
- He L
- Hedelin H
- Hochreiter WW
- Khadra A
- Kivioja J
- Korner H
- Malemud CJ
- Miller LJ
- Musil R
- Narumiya S
- Nickel JC
- Penna G
- Pontari MA
- Reiche EMV
- Rosendal L
- Schaeffer AJ
- Shoskes DA
- Thompson ME
- Vania Apkarian A
- Weidner W
- Whiteman M
- Yao MZ
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Does Delayed Graft Function Still Herald a Poorer Outcome in Kidney Transplantation?
- Author
- A Beiras-Fernandez
- A Loverre
- A Rojas-Pena
- A Weissenbacher
- AA Loo Van
- AE-NM Khwaja
- AIW Siedlecki
- AJ Matas
- AO Ojo
- AO Ojo
- C Marek
- C Moers
- C Moers
- C Noel
- CJ Shoskes DA
- CJE Watson
- CRJA Parikh
- CYPJ Lu
- DA Shoskes
- DM Summers
- F Gueler
- G Stallone
- HP Shoskes DA
- I Jochmans
- I Yokoyama
- IE Hall
- IEYS Hall
- J Gill
- J Treckmann
- J Wu
- JAMF Lopes
- JF Simon
- JL Gore
- JMKS O’Callaghan
- JT Rosenthal
- JTS Pratschke
- KH Polderman
- Kidney Disease: Improving Global Outcomes (KDIGO) Transplant Work Group
- LKMJ Kayler
- M Guba
- MA McAdams-DeMarco
- MCY Hirata
- MD Doshi
- ME Hollmen
- MERH Grams
- MGJ Snoeijs
- MGJ Snoeijs
- MRW Kosieradzki
- MSD West
- MZ Molnar
- N Perico
- OJ Kwon
- P Mahboub
- PM Buchanan
- PRG Nagaraja
- PS Almond
- R Bahde
- R Munivenkatappa
- RA McTaggart
- RA McTaggart
- RAAV Wolfe
- S Hariharan
- SG Yarlagadda
- SG Yarlagadda
- SHCP Chang
- SKCJ Akkina
- SN Tapiawala
- TF Fuller
- TJ Pianta
- TVFC Brennan
- VS Potluri
- W Lieberthal
- W Tahir
- WC Goggins
- WD Irish
- WK Wu
- WN Nijboer
- Y Avihingsanon
- Y Lebranchu
- Y Liu
- YM Woo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Spinal cord compression in prostate cancer
- Author
- A Achbarou
- American Cancer Society
- AW Partin
- CJ Vecht
- CSB Galasko
- D Goltzman
- DA Kuban
- DA Shoskes
- DF Flynn
- EM Smith
- F Graus
- FD Gaylis
- H-C Wu
- HJ Kaminski
- HS Greenberg
- JA Bonner
- JC Kirchheimer
- JC Kirchheimer
- JC Kirchheminer
- JP Constans
- JW Iacovou
- KD Harrington
- LD Rodichok
- LM Sullivan
- LWK Chung
- M Chackal-Roy
- M Haq
- MA Rosenthal
- ME Gleave
- MJ Zelefsky
- N Sundaresan
- N Sundaresan
- NM Hoosein
- PS Sorensen
- PW Kincade
- R Auerbach
- R Sadasivan
- RF Carmody
- RF Young
- RH Getzenberg
- RH Getzenberg
- RH Getzenberg
- RJ Stark
- RK Portenoy
- RW Gilbert
- SC Jacobs
- SG Tang
- T Siegal
- T Siegal
- TN Byrne
- VS Perkel
- W Hollas
- WL McKeehan
- Y Ushio
- Y Ushio
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1995
- Field of study
Effect of delayed graft function on longer‐term outcomes after kidney transplantation from donation after circulatory death donors in the United Kingdom: A national cohort study
- Author
- Akkina SK
- Ayorinde JOO
- Cepeda MS
- Eltzschig HK
- Gill J
- Hosgood SA
- Ibrahim M
- Johnson RJ
- Kok MJ
- Kostakis ID
- Levey AS
- Lim WH
- Lim WHP
- Liu L
- Locke JE
- Lomero M
- Mallon DH
- Moers C
- Nace G
- Oniscu GC
- Orban JC
- Qureshi F
- Rao PS
- Redfield RR
- Renkens JJ
- Schaapherder A
- Serrano OKMD
- Shamali A
- Shoskes DA
- Siedlecki A
- Singh RP
- Summers DM
- Summers DM
- Sureshkumar KK
- Thuong M
- Tingle SJ
- Valeri L
- Watson CJ
- Williams WW
- Yarlagadda SG
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Intravascular Ultrasound Detects Coarctation of the Renal Artery in a Patient with Moyamoya Disease.
- Author
- Choi Y Kang BC, Kim KJ, et al
- Ellison PH Largent JA, Popp AJ
- Gordin M Helias A, Tadie M, Fillas
- Halley SE White WB, Ramsby GR, Voy
- Hosoda Y
- Ikeda E
- Izumiya M Ise T, Takakuwa H, et al
- Jansen JN Donker AJM, Luth WJ, Smi
- KITAZAWA M
- KYORAKU Y
- Leertouwer TC Gussenhoven EJ, Bosc
- Leertouwer TC Gussenhoven EJ, van
- MIYAJIMA A
- NAKAMURA YOSHIYUKI
- Nakano T Azuma E, Ido M, et al
- Nishimoto A Takeuchi S
- Ramsay LE Waller PC
- Rupprecht T Wenzel D, Schmitzer E,
- Sheikh KH Davidson CJ, Newman GE,
- Shoskes DA Novick AC
- Tagami R Yamanaka M, Tada R, Yasud
- Tegtmeyer CJ Kellum CD, Ayers C
- Van der Vliet JA Zeilstra DJ, van
- Yamada I Himeno Y, Matsushima Y, S
- Yamashita M Tanaka K, Kishikawa T,
- Publication venue
- 'Japanese Society of Hypertension'
- Publication date
- 01/01/2001
- Field of study