Capital in the First Century: The Evolution of Inequality in Ancient Maya Society

This edited volume presents examples of social science research projects that employ new methods of quantitative analysis and mathematical modeling of social processes. This book presents the fascinating areas of empirical and theoretical investigations that use formal mathematics in a way that is accessible for individuals lacking extensive expertise but still desiring to expand their scope of research methodology and add to their data analysis toolbox. Mathematical Modeling of Social Relationships professes how mathematical modeling can help us understand the fundamental, compelling, and yet sometimes complicated concepts that arise in the social sciences. This volume will appeal to upper-level students and researchers in a broad area of fields within the social sciences, as well as the disciplines of social psychology, complex systems, and applied mathematics.https://nsuworks.nova.edu/shss_facbooks/1099/thumbnail.jp

Modulation of SERCA in the chronic phase of adjuvant arthritis as a possible adaptation mechanism of redox imbalance

Adjuvant arthritis (AA) is a condition that involves systemic oxidative stress. Unexpectedly, it was found that sarcoplasmic reticulum Ca2 +-ATPase (SERCA) activity was elevated in muscles of rats with AA compared to controls, suggesting possible conformational changes in the enzyme. There was no alteration in the nucleotide binding site but rather in the transmembrane domain according to the tryptophan polar/non-polar fluorescence ratio. Higher relative expression of SERCA, higher content of nitrotyrosine but no increase in phospholipid oxidation in AA SR was found. In vitro treatments of SR with HOCl showed that in AA animals SERCA activity was more susceptible to oxidative stress, but SR phospholipids were more resistant and SERCA could also be activated by phosphatidic acid. It was concluded that increased SERCA activity in AA was due to increased levels of SERCA protein and structural changes to the protein, probably induced by direct and specific oxidation involving reactive nitrogen species