I Misteri del Rosario

I Misteri del Rosario (the Mysteries of the Rosary) composed by Raffaello Agostini, Edoardo Soldi, and Antonino Ciardi in honor of Donato Velluti Zati di San Clemente, then Bishop of Pistoia and Prato. The work includes an introductory song, and songs for the Joyful, Sorrowful, and Glorious Mysteries of the Rosary. These songs were composed for a duet of two equal voices.https://ecommons.udayton.edu/imri_sheetmusic/1034/thumbnail.jp

A prognostic score for predicting survival in patients with pancreatic head adenocarcinoma and distal cholangiocarcinoma

Background/aim: Survival of patients with pancreatic cancer remains poor despite improvements in therapeutic strategies. This study aims to create a novel preoperative score to predict prognosis in patients with tumors of the pancreaticobiliary head. Patients and methods: Data on 190 patients who underwent to pancreaticoduodenectomy at Sapienza University of Rome from January 2010 to December 2018 were retrospectively analyzed. After exclusion criteria, 101 patients were considered eligible for retrospective study. Preoperative biological, clinical and radiological parameters were considered. Results: Pancreatic ductal adenocarcinoma [hazard ratio (HR)=1.995, 95% confidence intervaI (CI)=1.1-3.3; p=0.01], carbohydrate antigen 19.9 (CA 19.9) >230 U/ml (HR=2.414, 95% CI=2.4-1.5, p<0.0001) and Wirsung duct diameter >3 mm (HR=1.592, 95% CI=1.5-0.9; p=0.08) were the only parameters associated with poor prognosis. Through these parameters, a prognostic score (PHT score) was developed which predicted worst survival when exceeding 2 and better survival when ≤2. Conclusion: The PHT score may have a potential impact on predicting overall survival and consequently modulate the timing and type of treatment (up-front surgery vs. neoadjuvant therapy) patients are offered

Pancreatic ductal adenocarcinoma and distal cholangiocarcinoma: a proposal of preoperative diagnostic score for differential diagnosis

Purpose:The differential diagnosis between primary adenocarcinoma of the pancreas head and distalcholangiocarcinoma remains a clinical challenge. Recent studies have shown important differences in terms ofsurvival between these tumors. Therefore, different treatments should be considered, but the preoperativehistological diagnosis is still difficult. Aim of this study is to create a preoperative diagnostic score for differentialdiagnosis between primary pancreatic adenocarcinoma and primary distal cholangiocarcinoma.Methods:One hundred eighty consecutive patients who underwent pancreaticoduodenectomy at SapienzaUniversity of Rome from January 2010 to December 2019 were retrospectively analyzed. Inclusion criteria werepancreatic or biliary histologic origin obtained by definitive postoperative histological examination. Exclusion criteriawere diagnosis of ampullary carcinoma, non-ampullary duodenal adenocarcinoma, pancreatic metastasis, andbenign disease. One hundred one patients were considered eligible for the retrospective study. Preoperativebiological, clinical, and radiological parameters were considered.Results:CRP > 10 mg/dL (p= 0.001), modified Glasgow Prognostic Score 2 (p= 0.002), albumin < 35 g/L (p= 0.05),CA 19-9 > 230 U/mL (p= 0.001), and Wirsung diameter > 3 mm (p< 0.001) were significant at univariate logisticanalysis. Multivariate logistic analysis has shown that parameters independently associated with primary pancreaticadenocarcinoma were CRP > 10 mg/dL (p= 0.012), CA 19-9 > 230 U/mL (p= 0.043), and diameter of the Wirsung> 3 mm (p= 0.005). Through these parameters, a diagnostic score has been developed to predict a primarypancreatic adenocarcinoma when > 1 and a primary distal cholangiocarcinoma when < 1.Conclusion:This feasible and low-cost diagnostic score could have a potential impact to differentiate pancreaticcancer histologic origin and to improve target therapeutic strategy

Parasitic infections in an organic grazing cattle herd in Tuscany using geographic information systems to determine risk factors

An organic grazing cattle herd in Tuscany (Italy) was monitored for parasites between 2002 and 2006. Every two to three months, faecal samples from cattle of different breeds and age were collected and examined for endoparasites, using both qualitative and quantitative parasitological techniques. Several environmental parameters were monitored and data on biodiversity and field margin biodiversity of grazing areas were also collected. All data were geo-referenced and plotted on a vectorial map using geographic information systems (GIS) software. Soil was classified as silt and clay/sand. The hydraulic drainage was poor and water pooling was observed frequently. The biodiversity of field margins was relatively high. Cattle were infected by coccidia, gastrointestinal nematodes, cestodes and trematodes. Prevalence and intensity of infestations were highly variable. In most cases, this variability was related to cattle breed, age, season and meteorological data. The Pisana breed was most commonly infected by Fasciola hepatica and Paramphistomidae. These infestations were associated with more frequent flooding and water pooling in the areas grazed by this breed