5 research outputs found
Transgenic mouse model overexpressing spermine oxidase (SMO) to investigate the neurobiolological role of polyamine metabolism in physiological and pathological conditions
No full textConstruction of an enginereed mouse model over-expressing the homologous mouse spermine oxidase (mSMO) isoform
No full textEffects of overexpression of spermine oxidase (SMO) in kainic acid induced excitotoxicity
No full textMaize polyamine oxidase: primary structure from protein and cDNA sequencing
No full textThe first complete amino acid sequence of a flavin-containing polyamine oxidase was solved by a combined approach of nucleotide and peptide sequence analysis. A cDNA of 1737 bp, isolated from maize seedlings by reverse transcription-polymerase chain reaction and rapid amplification of cDNA ends strategies, was cloned and its sequence determined. This cDNA contains information for a polypeptide chain of 500 amino acids. Its amino-terminal sequence shows the typical features of secretion signal peptides. The primary structure of the mature protein was independently confirmed by extensive amino acid sequencing. Structural relationships with flavin-containing monoamine oxidases are also discussed
