153 research outputs found
Reach and grasp by people with tetraplegia using a neurally controlled robotic arm
- Author
- A Albu-Schaffer
- A Albu-Schaffer
- AB Schwartz
- AK Bansal
- AM Green
- B Jarosiewicz
- Beata Jarosiewicz
- C Mehring
- CA Chestek
- CE Vargas-Irwin
- CT Moritz
- Daniel Bacher
- DM Taylor
- E Stark
- EA Pohlmeyer
- EK Chadwick
- G Santhanam
- GH Mulliken
- GW Fraser
- HC Shin
- J Kruger
- JD Simeral
- Jie Liu
- Joern Vogel
- John D. Simeral
- John P. Donoghue
- JP Donoghue
- Leigh R. Hochberg
- LR Hochberg
- M Burrow
- M Velliste
- MAL Nicolelis
- Nicolas Y. Masse
- Patrick van der Smagt
- R Quian Quiroga
- S Haddadin
- S Musallam
- S Suner
- Sami Haddadin
- SP Kim
- SP Kim
- Sydney S. Cash
- TA Kuiken
- V Gilja
- W Wu
- WQ Malik
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 16/05/2012
- Field of study
Paralysis following spinal cord injury (SCI), brainstem stroke, amyotrophic lateral sclerosis (ALS) and other disorders can disconnect the brain from the body, eliminating the ability to carry out volitional movements. A neural interface system (NIS)1â5 could restore mobility and independence for people with paralysis by translating neuronal activity directly into control signals for assistive devices. We have previously shown that people with longstanding tetraplegia can use an NIS to move and click a computer cursor and to control physical devices6â8. Able-bodied monkeys have used an NIS to control a robotic arm9, but it is unknown whether people with profound upper extremity paralysis or limb loss could use cortical neuronal ensemble signals to direct useful arm actions. Here, we demonstrate the ability of two people with long-standing tetraplegia to use NIS-based control of a robotic arm to perform three-dimensional reach and grasp movements. Participants controlled the arm over a broad space without explicit training, using signals decoded from a small, local population of motor cortex (MI) neurons recorded from a 96-channel microelectrode array. One of the study participants, implanted with the sensor five years earlier, also used a robotic arm to drink coffee from a bottle. While robotic reach and grasp actions were not as fast or accurate as those of an able-bodied person, our results demonstrate the feasibility for people with tetraplegia, years after CNS injury, to recreate useful multidimensional control of complex devices directly from a small sample of neural signals
Reach and grasp by people with tetraplegia using a neurally controlled robotic arm
- Author
- A Albu-Schaffer
- A Albu-Schaffer
- AB Schwartz
- AK Bansal
- AM Green
- B Jarosiewicz
- Beata Jarosiewicz
- C Mehring
- CA Chestek
- CE Vargas-Irwin
- CT Moritz
- Daniel Bacher
- DM Taylor
- E Stark
- EA Pohlmeyer
- EK Chadwick
- G Santhanam
- GH Mulliken
- GW Fraser
- HC Shin
- J Kruger
- JD Simeral
- Jie Liu
- Joern Vogel
- John D. Simeral
- John P. Donoghue
- JP Donoghue
- Leigh R. Hochberg
- LR Hochberg
- M Burrow
- M Velliste
- MAL Nicolelis
- Nicolas Y. Masse
- Patrick van der Smagt
- R Quian Quiroga
- S Haddadin
- S Musallam
- S Suner
- Sami Haddadin
- SP Kim
- SP Kim
- Sydney S. Cash
- TA Kuiken
- V Gilja
- W Wu
- WQ Malik
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
- Ahlers M
- Ahrens M
- Aiello L
- Ain A
- Ajith P
- Akras S
- Al Samarai I
- Albert A
- Albert A
- Albuquerque IFM
- Albury JM
- Alcaniz JS
- Alexander KD
- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
- Allen B
- Allen G
- Allison J
- Allison JR
- Allocca A
- Almela A
- Altin PA
- Altmann D
- Alvarez C
- Alvarez JD
- Alvarez M Dovale
- Alvarez-Muiz J
- Amati L
- Amato A
- An T
- Ananyeva A
- Anastasi GA
- Anchordoqui L
- Andeen K
- Anderson JP
- Anderson SB
- Anderson T
- Anderson WG
- Andrada B
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- Angner EO
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- Aptekar RL
- Arai K
- Arakawa M
- Aramo C
- Araya MC
- Arcavi I
- Arceo R
- Ardid M
- Areeda JS
- Aresu G
- Argan A
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- Arnaud N
- Array LWA Long Wavelength
- Array MWA Murchison Widefield
- Arrieta M
- Arsene N
- Arteaga-Velzquez JC
- Artola R
- Arun KG
- Asakura Y
- Asaoka Y
- Ascenzi S
- Ashall C
- Ashley MCB
- Ashton G
- Asorey H
- Assis P
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- Astone P
- Atallah DV
- ATLAS
- Atwood WB
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- Austin C
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- Ziegler A
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- Zimnukhov DS
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- Zou CL
- Zuccarello F
- Zucker ME
- Zuniga J
- Zweizig J
- Zywucka N
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transientâs position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Localization and broadband follow-up of the gravitational-wave transient GW150914
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- Zweizig J
- Publication venue
- Astrophysical Journal Letters
- Publication date
- 01/01/2016
- Field of study
A gravitational-wave (GW) transient was identified in data recorded by the Advanced Laser Interferometer Gravitational-wave Observatory (LIGO) detectors on 2015 September 14. The event, initially designated G184098 and later given the name GW150914, is described in detail elsewhere. By prior arrangement, preliminary estimates of the time, significance, and sky location of the event were shared with 63 teams of observers covering radio, optical, near-infrared, X-ray, and gamma-ray wavelengths with ground- and space-based facilities. In this Letter we describe the low-latency analysis of the GW data and present the sky localization of the first observed compact binary merger. We summarize the follow-up observations reported by 25 teams via private Gamma-ray Coordinates Network circulars, giving an overview of the participating facilities, the GW sky localization coverage, the timeline, and depth of the observations. As this event turned out to be a binary black hole merger, there is little expectation of a detectable electromagnetic (EM) signature. Nevertheless, this first broadband campaign to search for a counterpart of an Advanced LIGO source represents a milestone and highlights the broad capabilities of the transient astronomy community and the observing strategies that have been developed to pursue neutron star binary merger events. Detailed investigations of the EM data and results of the EM follow-up campaign are being disseminated in papers by the individual teams
Scintillation light detection in the 6-m drift-length ProtoDUNE Dual Phase liquid argon TPC
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- Zimmerman ED
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- Zwaska R
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 16/07/2022
- Field of study
DUNE is a dual-site experiment for long-baseline neutrino oscillation studies, neutrino astrophysics and nucleon decay searches. ProtoDUNE Dual Phase (DP) is a 6Â Ă Â 6Â Ă Â 6Â m 3 liquid argon time-projection-chamber (LArTPC) that recorded cosmic-muon data at the CERN Neutrino Platform in 2019-2020 as a prototype of the DUNE Far Detector. Charged particles propagating through the LArTPC produce ionization and scintillation light. The scintillation light signal in these detectors can provide the trigger for non-beam events. In addition, it adds precise timing capabilities and improves the calorimetry measurements. In ProtoDUNE-DP, scintillation and electroluminescence light produced by cosmic muons in the LArTPC is collected by photomultiplier tubes placed up to 7Â m away from the ionizing track. In this paper, the ProtoDUNE-DP photon detection system performance is evaluated with a particular focus on the different wavelength shifters, such as PEN and TPB, and the use of Xe-doped LAr, considering its future use in giant LArTPCs. The scintillation light production and propagation processes are analyzed and a comparison of simulation to data is performed, improving understanding of the liquid argon properties
Measurement and interpretation of same-sign W boson pair production in association with two jets in pp collisions at s = 13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
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- Abusleme Hoffman AC
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- Zhemchugov A
- Zheng J
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- Zheng X
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- Zhong D
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- Zhulanov V
- Zimine NI
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- Ziolkowski M
- Zoccoli A
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- Zorbas TG
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- Zou W
- Zwalinski L
- Ă kesson TPA
- Ăncel ĂO
- ĆœeniĆĄ T
- ĆœivkoviÄ L
- Publication venue
- Springer Nature
- Publication date
- 01/04/2024
- Field of study
This paper presents the measurement of fducial and diferential cross sections for both the inclusive and electroweak production of a same-sign W-boson pair in association with two jets (W±W±jj) using 139 fbâ1 of proton-proton collision data recorded at a centre-of-mass energy of âs = 13 TeV by the ATLAS detector at the Large Hadron Collider. The analysis is performed by selecting two same-charge leptons, electron or muon, and at least two jets with large invariant mass and a large rapidity diference. The measured fducial cross sections for electroweak and inclusive W±W±jj production are 2.92 ± 0.22 (stat.) ± 0.19 (syst.)fb and 3.38±0.22 (stat.)±0.19 (syst.)fb, respectively, in agreement with Standard Model predictions. The measurements are used to constrain anomalous quartic gauge couplings by extracting 95% confdence level intervals on dimension-8 operators. A search for doubly charged Higgs bosons H±± that are produced in vector-boson fusion processes and decay into a same-sign W boson pair is performed. The largest deviation from the Standard Model occurs for an H±± mass near 450 GeV, with a global signifcance of 2.5 standard deviations
Combination of searches for heavy spin-1 resonances using 139 fbâ1 of proton-proton collision data at s = 13 TeV with the ATLAS detector
- Author
- Aad G
- Aakvaag E
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboelela M
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Ackermann A
- Adam Bourdarios C
- Adamczyk L
- Addepalli SV
- Addison MJ
- Adelman J
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agaras MN
- Agarwala J
- Aggarwal A
- Agheorghiesei C
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ahuja S
- Ai X
- Aielli G
- Aikot A
- Ait Tamlihat M
- Aitbenchikh B
- Aizenberg I
- Akbiyik M
- Akimov AV
- Akiyama D
- Akolkar NN
- Aktas S
- Al Khoury K
- Alberghi GL
- Albert J
- Albicocco P
- Albouy GL
- Alderweireldt S
- Alegria ZL
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi F
- Algren M
- Alhroob M
- Ali B
- Ali HMJ
- Ali S
- Alibocus SW
- Aliev M
- Alimonti G
- Alkakhi W
- Allaire C
- Allbrooke BMM
- Allen JF
- Allendes Flores CA
- Allport PP
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- Zhao Z
- Zhemchugov A
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- Zheng K
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- Zimine NI
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- Ă kesson TPA
- Ăncel ĂO
- ĆœeniĆĄ T
- ĆœivkoviÄ L
- Publication venue
- Springer Nature
- Publication date
- 19/04/2024
- Field of study
A combination of searches for new heavy spin-1 resonances decaying into different pairings of W, Z, or Higgs bosons, as well as directly into leptons or quarks, is presented. The data sample used corresponds to 139 fbâ1 of proton-proton collisions at
= 13 TeV collected during 2015â2018 with the ATLAS detector at the CERN Large Hadron Collider. Analyses selecting quark pairs (qq, bb,
, and tb) or third-generation leptons (ÏÎœ and ÏÏ) are included in this kind of combination for the first time. A simplified model predicting a spin-1 heavy vector-boson triplet is used. Cross-section limits are set at the 95% confidence level and are compared with predictions for the benchmark model. These limits are also expressed in terms of constraints on couplings of the heavy vector-boson triplet to quarks, leptons, and the Higgs boson. The complementarity of the various analyses increases the sensitivity to new physics, and the resulting constraints are stronger than those from any individual analysis considered. The data exclude a heavy vector-boson triplet with mass below 5.8 TeV in a weakly coupled scenario, below 4.4 TeV in a strongly coupled scenario, and up to 1.5 TeV in the case of production via vector-boson fusion
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
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- Abantanga F
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- Abbasy J
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- Abd El Hameed OS
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- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
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- Leanne Almanon C
- Lecompte J-F
- Lee C
- Lee EX
- Lee F
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- Lee KC
- Lee KY
- Lee TSB
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- Leone N
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- Leppaniemi A
- Leppaniemi A
- Leroux J
- Leung KW
- Leung MF
- Leusink A
- Lewis J
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- Li KKK
- Li WS
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- Liew I
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- Lilford R
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- Lim G
- Lim H
- Lim J
- Lim PJ
- Lim SJ
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- Lim SY
- Limache S
- Limaye N
- Limoges B
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- lo Conte A
- loaloa MR
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- Ma J
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- Macchitella Y
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- Maceviciute K
- Macfarlane A
- Machaca M
- Machain Vega GM
- Machain Vega GM
- Maciejec L
- Madiba T
- Madkor MH
- Madrid Barrientos LA
- Maffioli A
- Maffioli A
- Magdy A
- Magdy B
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- Magdy H
- Magdy M
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- Magee C
- Maghrabi A
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- Mahmoud B
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- Mamdouh R
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- Manchego Bautista AC
- Manchego Bautista AC
- Manfreda S
- Mangan C
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- Mangiapane M
- Manipal CE
- Maniscalco A
- Mann T
- Mannu GS
- Mano MJB
- Manrique Sila G
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- Mansor EY
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- Marroquin Rodriguez DE
- Marshall DC
- Martian B-V
- Martin A
- Mas R
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- Matos-Puig R
- Mattar O
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- Menegussi J
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- Merlo MS
- Mesbah N
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- Metwally MM
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- Mihaljevic AL
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- Mircea H
- Mirghani D
- Mironescu A
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- Mirza A
- Mirza S
- Mistry A
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- Mitroudi M
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- Moaty M
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- Modolo MM
- Moe TT
- Mogan YP
- Moghazy ME
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- Mohamed A
- Mohamed AM
- Mohamed AR
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed MA
- Mohamed MAEH
- Mohamed MM
- Mohamed O
- Mohamed SR
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
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- Mohammed AR
- Mohammed H
- Mohammed MM
- Mohammed MMH
- Mohammed S
- Mohan H
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- Mok YT
- Mokhtar A
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- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montoya Botero JA
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
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- Mora JJV
- Morales C
- Morandi E
- Moreira G
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- Morsi A
- Morsi M
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- Morton R
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- Mosalum O
- Mostafa HA
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
- Mouttalib S
- Mowafy B
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- Mshelbwala P
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- Pesenti G
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- Samaraweera DI
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- Snyder E
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- Sobnach S
- Sodde P
- Soeselo DA
- Sokratous A
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- Solar Garcia L
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- Soldevila-Verdeguer C
- Soley R
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- Soltani N
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- Sriram A
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- Stefanopoulos A
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- Summerour V
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- Taddei A
- Tade A
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- Tahboub H
- Taher AA
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- Taieb C
- Taiwo A
- Taiwo O
- Taiwo O
- Talaat M
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- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Separation of track- and shower-like energy deposits in ProtoDUNE-SP using a convolutional neural network
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
Liquid argon time projection chamber detector technology provides high spatial and calorimetric resolutions on the charged particles traversing liquid argon. As a result, the technology has been used in a number of recent neutrino experiments, and is the technology of choice for the Deep Underground Neutrino Experiment (DUNE). In order to perform high precision measurements of neutrinos in the detector, final state particles need to be effectively identified, and their energy accurately reconstructed. This article proposes an algorithm based on a convolutional neural network to perform the classification of energy deposits and reconstructed particles as track-like or arising from electromagnetic cascades. Results from testing the algorithm on data from ProtoDUNE-SP, a prototype of the DUNE far detector, are presented. The network identifies track- and shower-like particles, as well as Michel electrons, with high efficiency. The performance of the algorithm is consistent between data and simulation
Separation of track- and shower-like energy deposits in ProtoDUNE-SP using a convolutional neural network
- Author
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Liquid argon time projection chamber detector technology provides high spatial and calorimetric resolutions on the charged particles traversing liquid argon. As a result, the technology has been used in a number of recent neutrino experiments, and is the technology of choice for the Deep Underground Neutrino Experiment (DUNE). In order to perform high precision measurements of neutrinos in the detector, final state particles need to be effectively identified, and their energy accurately reconstructed. This article proposes an algorithm based on a convolutional neural network to perform the classification of energy deposits and reconstructed particles as track-like or arising from electromagnetic cascades. Results from testing the algorithm on experimental data from ProtoDUNE-SP, a prototype of the DUNE far detector, are presented. The network identifies track- and shower-like particles, as well as Michel electrons, with high efficiency. The performance of the algorithm is consistent between experimental data and simulation
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