10 research outputs found
Contact dermatitis and other skin conditions in instrumental musicians
- Author
- A Inoue
- A Inoue
- A Oga
- AA Fisher
- AA Fisher
- AA Fisher
- AA Fisher
- AA Fisher
- AA Fisher
- AA Fisher
- AH Bryan
- AH O'Hagan
- AJ Kanwar
- AM Zina
- BH Kaufman
- BM Hausen
- BM Hausen
- BM Hausen
- BM Hausen
- BM Hausen
- BM Hausen
- C Lerner
- C Lombardi
- C Pincelli
- CE Dettmann
- D Tennstedt
- DA Basketter
- DA Buckley
- DG Ross
- E Altenmüller
- E Carabias
- E Landeck
- E Rajna
- G Angelini
- G Färm
- G Kick
- G Marshman
- G Sebastian
- H Fruhstorfer
- HA Bird
- HD Lieberman
- HN Mandell
- J Blum
- J James
- J Machácková
- J Machácková
- J Murphy
- J Planas
- JB Stern
- JC Moreno
- JD Jago
- JE Wahlberg
- JM Destouet
- JM Lachappelle
- JM Murphy
- JM Thomas
- JP McFadden
- JR Nethercott
- JS Koransky
- K Bork
- K Bork
- L Peltonen
- LD Gardner
- LH Calabrese
- LJ Goldstein
- M Fishbein
- M Monti
- M Nakamura
- M Önder
- M Önder
- MA Ramirez
- Marcus Freitag
- MG Dahl
- MH Van der Wegen-Keijser
- NJ Reina
- NP Melia
- P Barkvoll
- P Barkvoll
- P Brun
- P Curtis
- P Thomas
- PA Piletta
- PE Shapiro
- R Baran
- R Semple
- RA Hoppmann
- RDG Peachey
- RJ Signore
- RM Adams
- S Freeman
- S Liu
- S Rimmer
- SJ Friedman
- Stefanie Boms
- T Burr
- TC Hindson
- Thilo Gambichler
- TN Helm
- UF Haustein
- Publication venue
- BioMed Central
- Publication date
- 01/04/2004
- Field of study
BACKGROUND: The skin is important in the positioning and playing of a musical instrument. During practicing and performing there is a permanent more or less intense contact between the instrument and the musician's skin. Apart from aggravation of predisposed skin diseases (e.g., atopic eczema or psoriasis) due to music-making, specific dermatologic conditions may develop that are directly caused by playing a musical instrument. METHODS: To perform a systematic review on instrument-related skin diseases in musicians we searched the PubMed database without time limits. Furthermore we studied the online bibliography "Occupational diseases of performing artist. A performing arts medicine bibliography. October, 2003" and checked references of all selected articles for relevant papers. RESULTS: The most prevalent skin disorders of instrumental musicians, in particular string instrumentalists (e.g., violinists, cellists, guitarists), woodwind players (e.g., flautists, clarinetists), and brass instrumentalists (e.g., trumpeters), include a variety of allergic contact sensitizations (e.g., colophony, nickel, and exotic woods) and irritant (physical-chemical noxae) skin conditions whose clinical presentation and localization are usually specific for the instrument used (e.g., "fiddler's neck", "cellist's chest", "guitar nipple", "flautist's chin"). Apart from common callosities and "occupational marks" (e.g., "Garrod's pads") more or less severe skin injuries may occur in musical instrumentalists, in particular acute and chronic wounds including their complications. Skin infections such as herpes labialis seem to be a more common skin problem in woodwind and brass instrumentalists. CONCLUSIONS: Skin conditions may be a significant problem not only in professional instrumentalists, but also in musicians of all ages and ability. Although not life threatening they may lead to impaired performance and occupational hazard. Unfortunately, epidemiological investigations have exclusively been performed on orchestra musicians, though the prevalence of instrument-related skin conditions in other musician groups (e.g., jazz and rock musicians) is also of interest. The practicing clinician should be aware of the special dermatologic problems unique to the musical instrumentalist. Moreover awareness among musicians needs to be raised, as proper technique and conditioning may help to prevent affection of performance and occupational impairment
Mind the Data Gap: Identifying and Assessing Drivers of Changing Eutrophication Condition
- Author
- A Borja
- A Borja
- A Borja
- A Steckbauer
- B Fertig
- B Fertig
- Benjamin Fertig
- CE Wazniak
- CM Duarte
- CM Wieben
- DA Tomasko
- DG Kimmel
- DM Anderson
- EH Dettmann
- FT Short
- GJ Niemi
- Gregg P. Sakowicz
- I Valiela
- J Hauxwell
- J Hauxwell
- JG Ferreira
- JH Daskin
- JM Burkholder
- JS Latimer
- K Hunchak-Kariouk
- L Carvalho
- LA Deegan
- Laura K. Reynolds
- M Elliott
- M Elliott
- M Williams
- MD Gastrich
- Michael J. Kennish
- MJ Kennish
- MJ Kennish
- MJ Kennish
- MJ Kennish
- MJ Kennish
- MJ Kennish
- RG Lathrop
- S Oliva
- SB Bricker
- SP Seitzinger
- T Srebotnjak
- TM Conway
- WK Dodds
- WM Kemp
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Tooth oxygen isotopes reveal Late Bronze Age origin of Mediterranean fish aquaculture and trade
- Author
- A Arndt
- A Gehler
- A Longinelli
- B Star
- C Chenery
- C Lécuyer
- C Lécuyer
- C Pierre
- C Pita
- CE Bernhardt
- CW Marean
- D Langgut
- D Sivan
- D Sivan
- DC Orton
- DC Orton
- DE Bar-Yosef Mayer
- DL Dettmann
- E Dufour
- E Galili
- E Pucéat
- E Vika
- G Sisma-Ventura
- G Sisma-Ventura
- G Sisma-Ventura
- H Elyashiv
- J Barrett
- J Barrett
- J Fischer
- K Lambeck
- L Chaoui
- L Tancioni
- MT Khalil
- N Porat
- N Raban-Gerstel
- O Otero
- S O’Connor
- SA Elgendy
- SF Mehanna
- SM Ahmed
- TW Vennemann
- W Neer Van
- W Neer Van
- Y Kolodny
- Y Kolodny
- ZD Sharp
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Characterization of Greenbeard Genes Involved in Long-Distance Kind Discrimination in a Microbial Eukaryote
- Author
- A Dereeper
- A Dettmann
- A Dettmann
- A Fleissner
- A Fleissner
- A Gardner
- A McKenna
- A Pandey
- A Rayner
- A Ross-Gillespie
- A Simonin
- A Stamatakis
- AB Goryachev
- AC Leeder
- AJ Debets
- AW De Tomaso
- AW De Tomaso
- B Langmead
- BS Arbogast
- C Fu
- C Hall
- C Sbrana
- CE Ellison
- CE Ellison
- D Charlesworth
- D Chevanne
- David J. Kowbel
- DC Queller
- DC Queller
- DC Queller
- DG Gibson
- DK Aanen
- DK Aanen
- DP Martin
- DX Zhang
- E Bastiaans
- E Szewczyk
- F Debets
- F Richard
- F Rousset
- Gabriel Rosenfield
- GH Choi
- GM Dunny
- GM Roca
- H Thorvaldsdottir
- HG Ljunggren
- HJ Vogel
- HV Colot
- I Teichert
- J Palma-Guerrero
- J Zhao
- JC Dunlap
- JE Galagan
- JE Strassmann
- JE Strassmann
- Jens Heller
- Jiuhai Zhao
- Joseph Heitman
- JR Dettman
- JR Dettman
- K Katoh
- K McCluskey
- KA Gibbs
- L Heaton
- L Li
- L Pieuchot
- M Freitag
- M Fricker
- M Giovannetti
- M Lopez-Villavicencio
- M Paoletti
- M Roca
- M Roper
- M Smith
- M Son
- M Westergaard
- MA Riley
- MN Pearson
- N. Louise Glass
- ND Read
- NL Glass
- NL Glass
- O Rendueles
- P Corcoran
- P Gladieux
- P Librado
- PC Hickey
- Pierre Gladieux
- RH Crozier
- RH Davis
- S Belanger
- S Biella
- S Capella-Gutierrez
- S Herzog
- S Hirose
- S Smukalla
- SA West
- SE Schoustra
- SF Altschul
- SJ Saupe
- T Boehm
- T Czaran
- TH Pittenger
- TR McKitrick
- V Ranwez
- W Jonkers
- W Li
- WD Hamilton
- Y Bernhards
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Septum Development in Neurospora crassa: The Septal Actomyosin Tangle
- Author
- A Berepiki
- A Dettmann
- A Fleissner
- AJ Clutterbuck
- AS Gladfelter
- C Richthammer
- CE Bracker
- CE Bulawa
- CG Rasmussen
- CL Araujo-Palomares
- D Justa-Schuch
- D Vavylonis
- Diego Luis Delgado-Álvarez
- DL Delgado-Alvarez
- DR Kovar
- E Yamada
- EF Sánchez-León-Hing
- F Chang
- F Liu
- G Jedd
- H Horiuchi
- H Si
- H Si
- I Weber
- J Bahler
- J Chant
- JM Kim
- JQ Wu
- JQ Wu
- L Serna
- M Fujiwara
- M Ichinomiya
- M Lord
- M Momany
- M Momany
- M Momany
- M Plamann
- M Riquelme
- M Riquelme
- M Riquelme
- M Sohrmann
- MEK Calvert
- MK Balasubramanian
- N Takeshita
- N Takeshita
- N Vogt
- O Hachet
- PC Hickey
- PF Minke
- RO Echauri-Espinosa
- Rosa Reyna Mouriño-Pérez
- RR Mouriño-Pérez
- RR Mouriño-Pérez
- RR Mouriño-Pérez
- S Fischer-Parton
- S Maerz
- S März
- S Seiler
- S Seiler
- Salomón Bartnicki-García
- SD Harris
- SD Harris
- SG Martin
- Stephan Seiler
- Steven Harris
- T Motoyama
- T Motoyama
- TD Pollard
- TD Wolkow
- VC Coffman
- Y Heilig
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Genome Wide Association Identifies Novel Loci Involved in Fungal Communication
- Author
- A De Antoni
- A Dettmann
- A Fleissner
- A Fleissner
- A Fleissner
- A Mahs
- A Pandey
- A Radford
- A Simonin
- AB Goryachev
- AL Weber
- AP Newman
- B Brachi
- BJ Bowman
- C Zhu
- CA Jones
- CE Ellison
- CF Connelly
- Charles R. Hall
- D Bridges
- David Kowbel
- DD Perkins
- DL Filiault
- DR TerBush
- E Conibear
- E De Castro
- E Leiter
- E Turner
- E Turner
- EK Chan
- G Liti
- GD Wright
- GM Roca
- H Kaur
- H Kim
- H Li
- H Saito
- HJ Vogel
- HV Colot
- I Letunic
- I Pocsi
- J Gromada
- Javier Palma-Guerrero
- JC Dunlap
- JC Schmit
- JE Galagan
- John W. Taylor
- Joshua M. Akey
- JR Dettman
- JR Dettman
- JR Mandel
- JS Dason
- Juliet Welch
- K McCluskey
- K McCluskey
- KA Borkovich
- KA Browne
- KB Hendricks
- L Bardwell
- L Demmel
- M Foulongne-Oriol
- M Freitag
- M Prigent
- M Roper
- M Westergaard
- MG Roca
- MM Magwire
- MN Price
- N. Louise Glass
- ND Rawlings
- ND Read
- ND Read
- P Chomczynski
- R Deka
- R Lombardi
- R Tamuli
- RA Fisher
- Rachel B. Brem
- RD Burgoyne
- RL Metzenberg
- S Atwell
- S Maerz
- SD Cappell
- T Strahl
- T Theis
- TF Mackay
- Y Bourne
- Y Kapp-Barnea
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Neogene Eastern Amazon carbonate platform and the palaeoenvironmental interpretation
- Author
- A Milne Edwards
- A Pérez-Ruzafa
- A Traverse
- AD Miall
- AM Góes
- AM Lalor
- AS Santos
- B Gell Van
- BK Horton
- C Hoorn
- C Hoorn
- C Hoorn
- C Hoorn
- C Hoorn
- C Paula-Couto
- C Singh
- CA Jaramillo
- CA White
- CE Schweitzer
- CE Schweitzer
- CJ Maury
- CS Ferreira
- DB Santos
- DF Rossetti
- DF Rossetti
- DF Rossetti
- DF Rossetti
- DW Roubik
- E Nakoman
- E Nakoman
- EG Sepúlveda
- EL Miner
- F Thiegart
- FG Bourrouilh-Le Jan
- FJ Rich
- FJ Vega
- FPR Leite
- FPR Leite
- G Playford
- GE Shephard
- H Dueñas
- H Karasawa
- IC Cookson
- IC Cookson
- IM Brito
- IM Brito
- IM Brito
- IM Brito
- J Figueiredo
- J Halfar
- J Iversen
- J Muller
- JBS Costa
- JD Dana
- JH Germeraad
- JMG Fernandes
- JMG Fernandes
- K Beurlen
- K Sakai
- KG Johnson
- LR Wilson
- M Arai
- M Hesse
- M Salard-Cheboldaeff
- M Salard-Cheboldaeff
- MA Gorini
- MA Kominz
- MA Lorente
- MB Bush
- ME Dettmann
- MECM Santos
- MECM Santos
- MJ Rathbun
- MSP Regali
- MV Sheffy
- N Uesugui
- NO Frederiksen
- O Aguilera
- O Aguilera
- O Aguilera
- O Bellwood
- O Legoux
- P Kumar
- P Szatmari
- PA Colinvaux
- PM Toledo
- PM Toledo
- PMJ Hoeken-Klinkenberg Van
- PMJ Hoeken-Klinkenberg Van
- PW Thomson
- R AzeBeardsley
- R Potonie
- R Potonie
- R Potonié
- R Potonié
- RB Manning
- RG Martins-Neto
- RG Martins-Neto
- RG Martins-Neto
- RG Walker
- RM Carter
- RS Santos
- RS Santos
- RT Clarke
- S Grave De
- S Petri
- S Petri
- SAF Silva-Caminha
- SCD Sah
- SCS Rafinesque
- T Hammen Van der
- T Hammen Van der
- T Hammen Van der
- T Hammen Van der
- T Hammen Van der
- TG Nyborg
- V Távora
- V Távora
- W Krutzsch
- W Punt
- WC Elsik
- WE Johns
- WE Johns
- WK Harris
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The influence of cyanobacteria blooms on the attenuation of nitrogen throughputs in a Baltic coastal lagoon
- Author
- A Deek
- A Grelowski
- AE Walsby
- AM Kamarainen
- AR Smyth
- B Adam
- B Andersson
- BA Lomstein
- BD Eyre
- BD Eyre
- BD Eyre
- BJ Robson
- CE Bower
- D Daunys
- D Jakimavičius
- D Poister
- D. Vaiciute
- DA Bronk
- DA Bruesewitz
- DA Bruesewitz
- DB Nedwell
- DL Findlay
- E Almroth-Rosell
- E Asmala
- E Cavaliere
- E Pina-Ochoa
- EH Dettmann
- Elizabeth W. Boyer
- ET Porter
- EW Boyer
- G Umgiesser
- H Radtke
- H Silvennoinen
- H Utermöhl
- HW Paerl
- I Valiela
- I Vybernaite-Lubiene
- I. Liskow
- I. Vybernaite-Lubiene
- J Cairns
- J Lesutienė
- J Petkuviene
- J. Petkuviene
- JD Wood
- JD Wood
- JDH Strickland
- JJ Hampel
- JM O’Neil
- K Grasshoff
- K Song
- K Sundbäck
- L Loken
- LB Knoll
- LR Ferber
- LS Hansen
- M Benavides
- M Bentzon-Tilia
- M Bertos-Fortis
- M Bresciani
- M Huettel
- M Présing
- M Voss
- M Zilius
- M Zilius
- M Zilius
- M. Bartoli
- M. Voss
- M. Zilius
- MC Murrell
- MJ McCarthy
- MJ McCarthy
- MR Mulholland
- N Brion
- N Motwani
- N Remekaite-Nikiene
- N Wannicke
- N Wasmund
- OP Savchuk
- P Zemlys
- P. A. Bukaveckas
- P. Zemlys
- PA Bukaveckas
- PA Bukaveckas
- PA Bukaveckas
- PJ Montoya
- PM Visser
- PM Vitousek
- R Pilkaitytė
- RW Fulweiler
- RW Howarth
- RW Howarth
- RW Howarth
- S Bonaglia
- S Hietanen
- S Hietanen
- S Seitzinger
- SE Newell
- SN Higgins
- SP Seitzinger
- ST Jeffrey
- SW Nixon
- T Dalsgaard
- T Großkopf
- TM Kana
- TR Parson
- TS Bianchi
- U Ohlendieck
- V Enoksson
- VH Smith
- VH Smith
- W Mohr
- Y Gao
- Z Chu
- Z Witek
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Ion Implantation
- Author
- A Addamiano
- A Addamiano
- A Andersson
- A Axmann
- A Axmann
- A Balazs
- A Barez
- A Barez
- A Blaha
- A Bontemps
- A Bontemps
- A Brelot
- A Corciovei
- A Corciovei
- A Desalvo
- A Desalvo
- A Desalvo
- A Desalvo
- A Feuerstein
- A Feuerstein
- A Feuerstein
- A Fiderkiewicz
- A Garin
- A Goetzberger
- A Golanski
- A Golanski
- A Golanski
- A Herman
- A Hiraki
- A Hornung
- A Kostka
- A Kostka
- A Kostka
- A Luches
- A Pegoraro
- A Piotrowski
- A Richardt
- A Strojnik
- A Toi
- A Wittkower
- AA Gavrilov
- AA Vlasov
- AA Vlasov
- AB Campbell
- AB Wittkower
- AD Vlasov
- AE Leneva
- AE Michel
- AF Akkerman
- AF Malov
- AG Zajdin
- AH Agajanian
- AH Greenaway
- AH Kachare
- AI Gerasimov
- AK Gnap
- ALM Davies
- AM Ghander
- AN Georgobiani
- AN Saxena
- Anon.
- Anon.
- Anon.
- AP Mamontov
- AP Mamontov
- AP Pathak
- AP Pathak
- AP Pathak
- AR Bayly
- AR Bayly
- AR Hutson
- AS Avakov
- AS Pasyuk
- AT Forrester
- AU MacRae
- AU MacRae
- AV Ryabtsov
- AV Vasilev
- AW Lees
- AW Tinsley
- B Crawford
- B Deveaud
- B Domeij
- B Hofflinge
- B Netange
- B Tell
- BA MacIver
- BA MacIver
- BC Feng
- BG Pettersson
- BI Bondarev
- BI Ivanov
- BI Vikhrev
- BJ Masters
- BJ Masters
- BJ Masters
- BJ Saealy
- BJ Sealy
- BJ Smith
- BK Herbert
- BK Shin
- BK Shin
- BL Crowder
- BL Crowder
- BL Crowder
- BL Crowder
- BL Crowder
- BM Welch
- BT French
- C Allen
- C Foster
- C Huang
- C Jech
- C Legrand
- C Lejeune
- C Lejeune
- C MacDonald
- C Weber
- CA Barile
- CB Fite
- CB Norris
- CB Norris
- CC Mai
- CC Wang
- CD Moak
- CE Hurwitz
- CF Pihl
- CJ Kircher
- CM Hsieh
- CP Wu
- CP Wu
- CR Allen
- CR Fritzsche
- CR Fritzsche
- CR Fritzsche
- CW Perkins
- D Eckstein
- D Lazarovici
- D Onnasch
- D Phillips
- D Popescu
- D Siguard
- D Sigurd
- DA Bromley
- DA Marsden
- DA Thompson
- DD Armstrong
- DD Sell
- DD Talada
- DE Davies
- DE Davies
- DE Davies
- DE Davies
- DE Davies
- DE Davies
- DG Armour
- DH Lee
- DH Lee
- DH Lee
- DH Lee
- DH Lee
- DJT Mayhall
- DK Abdrashitova
- DK Brice
- DK Brice
- DK Brice
- DK Brice
- DK Brice
- DK Brice
- DP Lecrosnier
- DS Gemmell
- DS Perloff
- DS Whitmell
- DTY Wei
- DV McCaughan
- DV McCaughan
- DV McCaughan
- DV McCaughan
- DV McCaughan
- DW Hafemeister
- E Baldo
- E Bogh
- E Harari
- E Heinick
- E Igras
- E Igras
- E Igras
- E Igras
- E Lugujjo
- E Norbeck
- E Pan
- E Rimini
- E Thompson
- E Zielinska-Rohozinska
- E Zorin
- E Zwangobani
- EA Heighway
- EC Bell
- ED Hudson
- ED Wolf
- EF Krimmel
- EF Krimmel
- EF Krimmel
- EH Bogardus
- EH Katt te
- EI Etingof
- EI Etingof
- EI Gerasimov
- EI Zorin
- EI Zorin
- EJM Kendall
- EK Baranova
- EK Baranova
- EK Baranova
- EM Bayadilov
- EM Beaver
- EM Schulson
- EN Vologdin
- EP EerNisse
- EP EerNisse
- EP EerNisse
- EP EerNisse
- EY Mikhlin
- F Abel
- F Brown
- F Burkhardt
- F Cappellani
- F Cembali
- F Cembali
- F Cembali
- F Cemy
- F Cerny
- F Charles
- F Chernow
- F Demichelis
- F Demichelis
- F Eichhorn
- F Fang
- F Fiorini
- F Fujimoto
- F Mezei
- FB Koch
- FE Irons
- FF Fang
- FF Morehead
- FF Morehead
- FF Morehead Jr.
- FH Eisen
- FH Eisen
- FH Eisen
- FJ Bryant
- FL Vook
- FL Vook
- FN Schvettman
- FN Schwettmann
- FN Schwettxnann
- FR Krueger
- FW Clinard Jr.
- FW Martin
- G Baccarani
- G Bertolini
- G Blet
- G Carter
- G Carter
- G Carter
- G Dearnaley
- G Dearnaley
- G Dearnaley
- G Dearnaley
- G Dearnaley
- G Dearnaley
- G Dearnaley
- G Delia Mea
- G Delia Mea
- G Delia Mea
- G Delia Mea
- G Delia Mea
- G Doucas
- G Eldridge
- G Fladda
- G Fladda
- G Gessinn
- G Gotz
- G Gotz
- G Hertenberger
- G Hoffman
- G Holmen
- G Holmen
- G Holmen
- G Ilic
- G Kelson
- G Mezey
- G Mezey
- G Philipp
- G Ryding
- G Ryding
- G Schwarz
- G Sidenius
- G Sixt
- G Weyer
- G Wood
- G Zuther
- GA Kachurin
- GA Kachurin
- GA Kachurin
- GH Marcus
- GH Schvuttke
- GH Schwuttke
- GH Schwuttke
- GI Robertson
- GI Uspenskaya
- GJ Fan
- GJ Kutcher
- GJ Rushton
- GM Filippov
- GN Flerov
- GP Lebedev
- GP Pokhil
- GR Ordette
- GW Arnold
- H Bach
- H Bernas
- H Boroffka
- H Boroffka
- H Ewald
- H Ezoe
- H Frey
- H Heinrich
- H Herzer
- H Ishimaru
- H Ishiwara
- H Kirschner
- H Krautel
- H Kudo
- H Maekawa
- H Matsuda
- H Matsumara
- H Muller
- H Muller
- H Muller
- H Mullier
- H Nishi
- H Nishi
- H Niu
- H Okabayashi
- H Okabayashi
- H Okabayashi
- H Runge
- H Runge
- H Runge
- H Runge
- H Ryssel
- H Ryssel
- H Ryssel
- H Rzewuski
- H Schmidt
- H Stoll
- H Sugiyama
- H Winter
- H Winter
- HA Grunder
- HE Roosendaal
- HE Wegner
- HG Dill
- HG Dill
- HG Mattes
- HJ Geipel
- HJ Matzke
- HJ Pabst
- HJ Pabst
- HJ Rohde
- HJ Rohde
- HJ Stein
- HJ Stein
- HJ Stein
- HJ Stein
- HJ Stein
- HM Naguib
- HM Naguib
- HR Bilger
- HR Zulliger
- HY Lee
- HY Lee
- I Hofmann
- I Lang
- I Manning
- I Ohdomari
- I Ohdomari
- I Ruge
- I Yoshida
- IA Novikov
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- WK Wu
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- WM Portnoy
- WM Pritchard
- WM Pritchard
- WN Hammer
- WN Hammer
- WS Johnson
- Y Akasaka
- Y Akasaka
- Y Akasaka
- Y Akasaka
- Y Kato
- Y Krylov
- Y Makita
- Y Makita
- Y Makita
- Y Ohmura
- Y Okuyama
- Y Ono
- Y Quere
- Y Quere
- Y Segawa
- Y Shiraki
- Y Wada
- Y Yuba
- Y Zohta
- YG Kozlov
- YH Ohtsuki
- YH Ohtsuki
- YH Ohtsuki
- YM Khirnyi
- YN Shutov
- YS Akimov
- YS Park
- YS Park
- YS Park
- YV Bulgakov
- YV Bulgakov
- YV Bulgakov
- YV Bulgakov
- YV Gorelkinskii
- YV Martynenko
- YZ Akilov
- Z Szmid
- ZC Putney
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1976
- Field of study
Edoxaban versus warfarin in patients with atrial fibrillation
- Author
- Abdullakutty J
- Abi-Mansour P
- Abril SB
- Accini J
- Accini M
- Acikel M
- Acikel M
- Adachi C
- Adams K
- Adams K
- Adamus J
- Adler J
- Adler P
- Agarwal D
- Aggarwal R
- Aggarwal R
- Agirov M
- Agraou B
- Ahmad A
- Ahmadpour H
- Ahuad Guerrero R
- Ajioka M
- Akhter F
- Akihisa U
- Akilli H
- Al-Maliky T
- Al-Zoebi A
- Albert L. Waldo
- Albisu J
- Albulescu P
- Alexander J
- Alexandrova L
- Alexopoulos D
- Alexopoulos D
- Alhakim M
- Aliyar P
- Allall O
- Allison J
- Allman J
- Almaraz SP
- Almeida A
- Almeida M
- Almquist A
- Aloni I
- Alsheikh T
- Altonen D
- Alvarez C
- Alvarez M
- Alvarez RF
- Amarenco P
- Amato Vincenzo de Paola A
- Ambrovic I
- Ambrovicova V
- Ameriso P
- Ameriso S
- Amin K
- Amin M
- Amuchastegui M
- Anciu M
- Anderson C
- Anderson J
- Anderson J
- Andersson R
- Andor M
- Andrade Lotufo P
- Andresen T
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- Antman EM
- Antonino M
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- Apetrei E
- Apostolovic S
- Appelros P
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- Arakawa S
- Araújo E
- Archibald J
- Arcocha Torres M
- Ardelean A
- Arfaoui M
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- Armas BH
- Arneja J
- Arnold T
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- Arora V
- Arouni A
- Arrieta M
- Arroyave C
- Arstall M
- Arutyunov G
- Asakura H
- Asensio A
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- Ata N
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- Atkinson C
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- Aude Y
- Augusto Alves da Costa F
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- Chaves Junior H
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- Young C
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- Yukhno E
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- Zachar A
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- Zamlynskyy M
- Zamorano JL
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- Zarpentin C
- Zateyshchikov D
- Zateyshchikova A
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- Zhang HQ
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- Zubeeva G
- Zyatenkova E
- Åkerberg A
- Östberg S
- Ŝpinar J
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2013
- Field of study
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125374.pdf (publisher's version ) (Open Access)BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS: We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. RESULTS: The annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P<0.001 for noninferiority) and 1.61% with low-dose edoxaban (hazard ratio, 1.07; 97.5% CI, 0.87 to 1.31; P=0.005 for noninferiority). In the intention-to-treat analysis, there was a trend favoring high-dose edoxaban versus warfarin (hazard ratio, 0.87; 97.5% CI, 0.73 to 1.04; P=0.08) and an unfavorable trend with low-dose edoxaban versus warfarin (hazard ratio, 1.13; 97.5% CI, 0.96 to 1.34; P=0.10). The annualized rate of major bleeding was 3.43% with warfarin versus 2.75% with high-dose edoxaban (hazard ratio, 0.80; 95% CI, 0.71 to 0.91; P<0.001) and 1.61% with low-dose edoxaban (hazard ratio, 0.47; 95% CI, 0.41 to 0.55; P<0.001). The corresponding annualized rates of death from cardiovascular causes were 3.17% versus 2.74% (hazard ratio, 0.86; 95% CI, 0.77 to 0.97; P=0.01), and 2.71% (hazard ratio, 0.85; 95% CI, 0.76 to 0.96; P=0.008), and the corresponding rates of the key secondary end point (a composite of stroke, systemic embolism, or death from cardiovascular causes) were 4.43% versus 3.85% (hazard ratio, 0.87; 95% CI, 0.78 to 0.96; P=0.005), and 4.23% (hazard ratio, 0.95; 95% CI, 0.86 to 1.05; P=0.32). CONCLUSIONS: Both once-daily regimens of edoxaban were noninferior to warfarin with respect to the prevention of stroke or systemic embolism and were associated with significantly lower rates of bleeding and death from cardiovascular causes. (Funded by Daiichi Sankyo Pharma Development; ENGAGE AF-TIMI 48 ClinicalTrials.gov number, NCT00781391.)