Cyclooxygenase-2 inhibition does not impair block bone grafts healing in rabbit model

Success of alveolar reconstructions using onlay autogenous block bone grafts depends on their adequate integration to the recipient bed influenced by a number of local molecules. Considering the fundamental role of cyclooxygenase (COX-2) in bone repair, the aim of this study was to analyze the effect of its inhibition in the integration of endochondral (EC) iliac crest, and intramembranous (IM) calvaria bone grafts. Thirty-two rabbits were divided into 4 groups: Calvaria Control (CC) and Iliac Control—treated with oral 0.9 % saline solution, and Calvarial-NSAID (C-NSAID) and Iliac-NSAID (I-NSAID) groups—treated with oral 6 mg/Kg non-steroidal anti-inflammatory drug etoricoxib. After 7, 14, 30 and 60 days the animals were euthanized and the specimens removed for histological, histomorphometric and immunohistochemistry analysis. At day 60, a tight integration of IM blocks could be seen with the presence of remodeling bone, whereas integration of EC grafts was mainly observed at the edges of the grafts. A significant higher percentage of bone matrix in the interface region of the CC grafts in comparison to C-NSAID only at day 14, whereas no differences were detected comparing the EC grafts. No differences were observed in Runx-2 and vascular endothelial growth factor (VEGF) immunolabeling when comparing CC and C-NSAID groups, while a significant weaker Runx-2 and VEGF labeling was detected in I-NSAID group at day 60. Although some influence was detected in osteogenesis, it is concluded that drug induced inhibition of COX-2 does not impair onlay bone grafts’ healing of both embryologic origins in rabbits

What do petrochemical workers, healthcare workers, and truck drivers have in common? Evaluation of sleep and alertness in Brazilian shiftworkers O que têm em comum os trabalhadores da indústria petroquímica, profissionais de saúde e caminhoneiros? Sono e vigília entre trabalhadores em turnos no Brasil

The article reports briefly on some effects of shiftwork and the work environment on health and wellbeing of shiftworkers. Studies of Brazilian shiftworkers (healthcare workers, petrochemical workers, and truck drivers) are described. A similar methodology was used to evaluate sleep and alertness in all these studies. The evaluation of sleep duration and quality and alertness showed similar results in the three studies. Although the workers were in different work settings, performing different jobs, the results are similar: daytime sleep is reduced and perceived as having worse quality than nighttime sleep; alertness decreases as the night work progresses. The study highlights the importance of shiftwork schedules' features and work organization for workers' health, wellbeing, and safety.<br>Este artigo apresenta de forma resumida os efeitos do trabalho em turnos na saúde e bem-estar dos trabalhadores. São apresentados estudos conduzidos em hospitais, indústria petroquímica e companhias de caminhões de carga. Foi utilizada metodologia semelhante nos estudos descritos para avaliação da duração e qualidade do sono, assim como do alerta durante o trabalho. Apesar dos trabalhadores realizarem tarefas bastante distintas, os resultados das avaliações de sono e alerta foram semelhantes: os trabalhadores após turnos noturnos apresentaram sono mais curto do que após outros turnos, comparados consigo mesmos e/ou com seus colegas de turnos diurnos. É enfatizada a importância da escala em turnos, assim como da organização do trabalho, para auxiliar os trabalhadores a manterem sua saúde, bem-estar e segurança no trabalho