CZE determination of somatostatin in pharmaceutical preparations

We propose a simple and accurate method for CE quantitative determination of somatostatin in pharmaceutical preparations. The method is specific for somatostatin as indicated by the resolution between the analyte and the analogue peptides which differ from somatostatin by one aminoacid. The linearity range is from 0.02 to 0.35 mg/ml. The recovery of the somatostatin from a pharmaceutical product is about 100.0%. (C) 2000 Elsevier Science B.V. All rights reserved

Analisi dello Stanozololo e suoi metaboliti in urine bovine mediante LC-MS-MS

C.N.R.-AREA DELLA RICERCA DI ROMA

HPLC and GC-MS detection of compounds released to mineral waters stored in plastic bottles of PET and PVC

The migration of certain compds. from PET [poly(ethylene terephthalate)] and poly(vinyl chloride) bottles to waters was studied by HPLC with UV detection after extn. with di-Et ether. Compds. in mineral waters were identified by gas chromatog.-mass spectrometry (GC-MS). Erucamide, from PET bottles, was quant. detd. in some mineral waters. Two other compds., also detected in mineral waters stored in PET, were identified as low-mol.-wt. cyclic oligomers produced during the PET polymn. process

ANALYSIS OF CLENBUTEROL BY GC-MS-TOF

URBIN

ANALISI MEDIANTE HPLC-MS-MS DEI BIOFENOLI DELLE OLIVE MEDITERRANEE

RIMIN

RAPID ANALYSIS OF MELATONIN IN PHARMACEUTICAL TABLETS BY CAPILLARY ELECTROPHORESIS WITH UV DETECTION

Melatonin content in pharmaceutical products was quantitatively determined by capillary electrophoresis within 4 min. Sample preparation required the simple dissolution in water and filtration.An internal standard was used, a linear relationship between malatonine concentr. and R(melatonin corrected peak area/I.S. corrected area was obtained. Separations were carried out in a coated capillaries in borate running buffer. The method showed an high precision with a RSD for migration time of 0.3% for intra-day and 1.4%for inter-day measures (n=48). For the R parameter RSD was 2.9% and refers to seven consecutive runs of the same sample on the same day. Two commercially available pharmaceutical products containing melatonin were analysed. The method offers an easy and accurate routin option

Capillary zone electrophoresis of some organic acids in milk whey

This paper describes a method for analysing some acids in milk whey by Capillary Electrophoresis.After eliminating of whey proteins by ultrafiltration, the whey underwent electrophoretic separation in the presence of anodic electrophoretic flow. The following analytes were detected:citric, orotic, uric and hippuric acids. A procedure is described for sample preparation and the operating conditions for electrophoretic capillary separation established. Finally, orptic acid is quantitatively determined