Desempenho e característica de carcaça de bovinos de corte alimentados com diferentes teores de lipídeos na dieta.

Este trabalho foi realizado para se avaliar o desempenho animal e a característica da carcaça de bovinos alimentados com três diferentes teores de lipídeos na dieta. Foram utilizados dezoito novilhos Nelore, castrados, com peso médio inicial de 370 kg em delineamento inteiramente casualizados com seis animais por tratamento. Os animais foram confinados por 84 dias, recebendo dietas com diferentes teores de lipídeos (2%, 4% e 6%), sendo abatidos ao atingirem em média, 480 kg de peso corporal. Após 24 horas de refrigeração, calculou-se o rendimento de carcaça (RC), área de olho de lombo (AOL) e a espessura de gordura subcutânea (EGS). Os animais não apresentaram diferenças significativas para RC, AOL e EGS. O consumo de matéria seca, conversão alimentar e eficiência alimentar também não foram afetados pelos diferentes teores de lipídeos da dieta. A decisão final pela escolha do teor de lipídeos a ser usado na dieta vai depender do custo, logo que os diferentes teores testados não apresentaram melhora sobre o desempenho e características de carcaça

STAT3 inhibition with Galiellalactone effectively targets the prostate cancer stem-like cell population."

Cancer stem cells (CSCs) are a small subpopulation of quiescent cells with the potential to differentiate into tumor cells. CSCs are involved in tumor initiation and progression and contribute to treatment failure through their intrinsic resistance to chemo- or radiotherapy, thus representing a substantial concern for cancer treatment. Prostate CSCs’ activity has been shown to be regulated by the transcription factor Signal Transducer and Activator of Transcription 3 (STAT3). Here we investigated the effect of galiellalactone (GL), a direct STAT3 inhibitor, on CSCs derived from prostate cancer patients, on docetaxel-resistant spheres with stem cell characteristics, on CSCs obtained from the DU145 cell line in vitro and on DU145 tumors in vivo. We found that GL significantly reduced the viability of docetaxel-resistant and patient-derived spheres. Moreover, CSCs isolated from DU145 cells were sensitive to low concentrations of GL, and the treatment with GL suppressed their viability and their ability to form colonies and spheres. STAT3 inhibition down regulated transcriptional targets of STAT3 in these cells, indicating STAT3 activity in CSCs. Our results indicate that GL can target the prostate stem cell niche in patient-derived cells, in docetaxel-resistant spheres and in an in vitro model. We conclude that GL represents a promising therapeutic approach for prostate cancer patients, as it reduces the viability of prostate cancer-therapy-resistant cells in both CSCs and non-CSC populations

Sindicalismo dos trabalhadores em Educação: tendências políticas e organizacionais (1978-2011)

O trabalho identifica as principais tendências políticas e organizacionais que reconstituíram as organizações de trabalhadores em educação no período 1978-2011 e sistematiza como se expressaram em cada estado os processos de criação, unificação e divisão de entidades; ampliação da base de representação; constituição como sindicato legalmente reconhecido; crescimento da filiação; e filiação e desfiliação à Central Única dos Trabalhadores (CUT)

Proteomic Changes of Alveolar Lining Fluid in Illnesses Associated with Exposure to Inhaled Non-Infectious Microbial Particles

Peer reviewe

Novel high-power-factor ZCS-PWM preregulators

This paper introduces novel zero-current-switching (ZCS) pulsewidth-modulated (PWM) preregulators based on a new soft-commutation cell, suitable for insulated gate bipolar transistor applications. The active switches in these proposed rectifiers turn on in zero current and turn off in zero current-zero voltage. In addition, the diodes turn on in zero voltage and their reverse-recovery effects over the active switches are negligible. Moreover, based on the proposed cell, an entire family of de-to-de ZCS-PWM converters can be generated, providing conditions to obtain naturally isolated converters, for example, derived buck-boost, Sepic. and Zeta converters. The novel ac-to-dc ZCS-PWM boost and Zeta preregulators are presented in order to verify the operation of this soft-commutation cell, In order to minimize the harmonic contents of the input current, increasing the ac power factor, the average-current-mode control is used, obtaining preregulators with ac power factor near unity and high efficiency at wide load range. The principle of operation, theoretical analysis, design example, and experimental results from test units for the novel preregulators are presented. The new boost preregulator was designed to nominal values of 1.6 kW output power, 220 V(rms) input voltage, 400 V(dc) output voltage, and operating at 20 kHz. The measured efficiency and power factor of the new ZCS-PWM boost preregulator were 96.7% and 0,99, respectively, with an input current total harmonic distortion (THD) equal to 3.42% for an input voltage with THD equal to 1.61%, at rated load, the new ZCS-PWM Zeta preregulator was designed to voltage step-down operation, and the experimental results were obtained from a laboratory prototype rated at 500 W, 220 V(rm), input voltage, 110 V(dc) output voltage, and operating at 50 kHz. The measured efficiency of the new ZCS-PWM Zeta preregulator is approximately 96.9% and the input power factor is 0.98, with an input current THD equal to 19.07% while the input voltage THD is equal to 1.96%, at rated load