Cognitive impairment among World Trade Center responders: Long-term implications of re-experiencing the 9/11 terrorist attacks

AbstractIntroductionDuring the World Trade Center (WTC) attacks, responders who helped in search, rescue, and recovery endured multiple traumatic and toxic exposures. One-fifth subsequently developed post-traumatic stress disorder (PTSD). PTSD has been linked to dementia in veterans. This study examined the association between WTC-related PTSD and cognitive impairment (CI) in WTC responders.MethodsA one-third sample of responders (N = 818) reporting for annual monitoring visits were screened for cognitive impairment and dementia using the Montreal Cognitive Assessment from January 2014–April 2015. Concurrent diagnoses of PTSD and major depressive disorder (MDD), as well as serial PTSD and depressive symptom inventories, collected since 2002, were examined in relation to current CI.ResultsApproximately 12.8% and 1.2% of responders in this sample respectively had scores indicative of CI and possible dementia. Current PTSD and MDD were associated with CI. Longitudinal results revealed that re-experiencing symptoms were consistently associated with CI (aRR = 2.88, 95% confidence interval = 1.35–6.22), whereas longitudinal increases in other PTSD and depressive symptoms in the years before screening were evident only among those with CI.ConclusionsAnalyses replicated results from Veterans studies and further highlighted the importance of re-experiencing symptoms, a major component of PTSD that was consistently predictive of CI 14 years later. Clinicians should monitor CI when treating individuals with chronic PTSD

EFEITO DO CARBARYL SOBRE O 'RUSSETING' DA MAÇÃ (MALUS DOMESTICA BORKH.), CULTIVARES 'GALA', 'FUJI' E 'GOLDEN DELICIOUS' EFFECT OF CARBARYL ON RUSSETING OF APPLE (Malus domestica Borkh.), CULTIVARS 'GALA', 'FUJI' AND 'GOLDEN DELICIOUS'

O "russeting" da maçã caracteriza-se por uma camada de cortiça formada entre as células da epiderme e que dá um aspecto de rugosidade à superfície do fruto, depreciando-o para a comercialização. O raleio de frutos é uma prática cultural bastante difundida entre os produtores de maçã. Pode ser efetuada manualmente, quimicamente ou pela associação de ambos. Dentre os produtos mais usados para raleio químico, estão o ácido naftaleno acético (ANA) e o carbaryl, um inseticida carbamato, conhecido comercialmente como Sevinâ. Há duas formulações de carbaryl no mercado brasileiro, mas não existem dados de pesquisa suficientes que permitam escolher a formulação mais adequada. Há citações de que o carbaryl pode causar "russeting" em maçãs. O objetivo deste trabalho foi testar as duas formulações de carbaryl existentes no mercado, quanto ao seu efeito sobre o "russeting" nas maçãs. Os experimentos foram conduzidos em Fraiburgo e em Caçador, Santa Catarina, Brasil. Foram avaliadas duas concentrações, 500 ppm e 1.500 ppm de carbaryl. Foram testadas duas formulações, uma em pó-molhável com 85% de i.a. e outra em suspensão concentrada com 48% de i.a. Como a incidência de "russeting" varia entre cultivares, testou-se em 'Gala', 'Fuji' e 'Golden Delicious', que são as três mais importantes no mercado brasileiro. Os resultados mostraram que: 1) A ocorrência de "russeting" para as três cultivares foi maior em Fraiburgo do que em Caçador; 2) O carbaryl, na formulação solução concentrada, causou mais "russeting" em 'Golden Delicious', em Caçador, indicando que o seu uso deve ser evitado para essa cultivar, dando-se preferência à formulação pó-molhável; 3)Tanto a formulação quanto a concentração de carbaryl não afetaram a incidência de "russeting" nas cultivares 'Gala' e 'Fuji' nos dois locais.<br>Russeting is characterized by the development of a cork layer among the epidermal cells giving an aspect of rugosity to the fruit surface, reducing its marketability. Fruit thinning is a technique widely used by apple growers. It can be done by hand or by using chemical thinning or by both, chemical and hand thinning. Among the most used chemical for thinning are naphthaleneacetic acid (NAA) and the insecticide carbaryl, commonly known as Sevinâ. In the Brazilian market there are two formulations of carbaryl: wetted powder and flowable solution. None of them are registered as chemical thinning for apple in Brazil. However there is not enough official research data in Brazil in this area that could support the best choice as far as russeting on the fruit is concerned. Some authors say that carbaryl may cause russeting on apples. This trial aimed to evaluate the two carbaryl formulations comparing its effect concerned to russeting. The experiments were carried out in two areas: Fraiburgo and Caçador, Santa Catarina State, Brazil. Two concentrations: 500 ppm and 1.500 ppm of each formulation were tested. One of the formulations was a wetted powder with 85% of a.i., the other was a flowable solution with 48% of a.i. As the incidence of russeting on apple may vary according to cultivar, the experiments were carried out on 'Gala', 'Fuji' and 'Golden Delicious'. It was concluded that: 1) Fraiburgo climactic conditions were much more favorable to russeting than those in Caçador; 2) carbaryl did not cause russeting on 'Gala' and 'Fuji' in both locations; 3) Carbaryl as flowable solution caused more russeting in 'Golden Delicious' at Caçador, so this formulation should not be recommended for this cultivar