The Use of Digital Portfolio in Higher Education before and during the COVID-19 Pandemic

This study is focused on the advantages and disadvantages of using a digital portfolio to improve the learning and evaluation processes in the initial teacher training of 4th-year students in the University of Seville (Spain). One of the interests of this research was to compare the learning capacities perceived by the students to improve their learning process before and during the COVID 19 pandemic. A qualitative, descriptive methodology was applied, identifying the most relevant dimensions, categories and codes for the analysis, management and interpretation of the opinions of the students, with a research triangulation (Cohen’s kappa coefficient) and a coding performed using the ATLAS.ti 8.4 software. The results show that the advantages with greater percentage correspond to the following categories: learning, usefulness of OneDrive, autonomy and evaluation. The greatest disadvantages detected were: time, uncertainty, usefulness of OneDrive and autonomy. There are differences in the perceptions of the students, between before and during the COVID-19 pandemic, about the learning capacities developed with the use of digital portfolio, since they consider that they have acquired more significant learning, greater self-regulation of their learning and greater reflection capacity

The Courel Mountains UNESCO Global Geopark: An Amazing Geological History Extended Along 600 Million Years

[EN] The Courel Mountains UNESCO Global Geopark (2019) stands out in SW of Europe because of its geoheritage, its biodiversity and its cultural heritage, all of it considered of international interest. These aspects shape the local development economic and cultural improvement and development. The geoheritage is the result of three geological cycles since the Proterozoic, involving the Cadomian-Avalonian-Pan-African orogeny, the opening of the Rheic Ocean and the Variscan orogeny, and finally the Permian-Mesozoic continental expansion and the Alpine orogeny. The geological history of Courel Mountains is one of singular rocks, huge recumbent folds, valuable metallic mineralization, and invertebrate fossils preserved within metamorphic rocks. This long history is recorded in an exceptional Variscan basement that we can ravel thanks to the exhumation during the Alpine uplifting, when the present-day Courel Mountains were built.Peer reviewe

JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality

Using AI, we identified baricitinib as having antiviral and anticytokine efficacy. We now show a 71% (95% CI 0.15 to 0.58) mortality benefit in 83 patients with moderate-severe SARS-CoV-2 pneumonia with few drug-induced adverse events, including a large elderly cohort (median age, 81 years). An additional 48 cases with mild-moderate pneumonia recovered uneventfully. Using organotypic 3D cultures of primary human liver cells, we demonstrate that interferon-α2 increases ACE2 expression and SARS-CoV-2 infectivity in parenchymal cells by greater than fivefold. RNA-seq reveals gene response signatures associated with platelet activation, fully inhibited by baricitinib. Using viral load quantifications and superresolution microscopy, we found that baricitinib exerts activity rapidly through the inhibition of host proteins (numb-associated kinases), uniquely among antivirals. This reveals mechanistic actions of a Janus kinase-1/2 inhibitor targeting viral entry, replication, and the cytokine storm and is associated with beneficial outcomes including in severely ill elderly patients, data that incentivize further randomized controlled trials

Effect of the addition of L-carnitine and pyruvate on the functionality of cryopreserved equine sperm

Cryopreservation of equine semen represents an important tool to improve reproductive management, however the use of frozen equine semen is still limited due to the poor tolerance of equine sperm to freezing and thawing processes. The aim of the present study was to evaluate the effect of the addition of L-carnitine and sodium pyruvate to the freezing medium on sperm parameters and pregnancy rates. L-carnitine and sodium pyruvate were added to the freezing medium of the treatment group and cryopreservation was performed with a rapid freezing curve. The samples were thawed and evaluated for sperm mobility, viability, morphology, membrane functionality, and acrosome integrity. To assess pregnancy rates, 20 mares were inseminated. In the results it was observed that the addition of L-carnitine and pyruvate in the post-thawed equine semen did not improve the results in terms of progressive motility and other kinetic parameters. The percentage of acrosome / HOS positive, the percentage of live sperm with intact acrosome, and the percentage of normal sperm were significantly higher in the L-carnitine and pyruvate samples. On the other hand, no improvements in the pregnancy rate were observed compared to that obtained using the semen of the post-thawed control group.Fil: Olmos Acevedo, R. Hospital Veterinario Central del Ejército del Perú. Lima, PerúFil: Caldevilla, M. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Teriogenología. Buenos Aires, ArgentinaFil: Caldevilla, M. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Instituto de Investigación y Tecnología en Reproducción Animal (INITRA). Buenos Aires, ArgentinaFil: Bruno, S. Dirección de Remonta y Veterinaria. Haras Militar General Lavalle. Buenos Aires, ArgentinaFil: Miragaya, M. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Teriogenología. Buenos Aires, ArgentinaFil: Miragaya, M. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Instituto de Investigación y Tecnología en Reproducción Animal (INITRA). Buenos Aires, ArgentinaLa criopreservación de semen equino representa una herramienta importante para mejorar el manejo reproductivo, sin embargo, el uso de semen equino congelado es aún limitado debido a la escasa tolerancia de los espermatozoides equinos a los procesos de congelación y descongelación. El objetivo del presente estudio fue evaluar el efecto de la adición de Lcarnitina y piruvato de sodio al medio de congelamiento, sobre los parámetros espermáticos y la tasa de preñez. Se adicionó L-carnitina y piruvato de sodio al medio de congelamiento y se congeló con una curva rápida. Las muestras fueron descongeladas y evaluadas para movilidad espermática, viabilidad, morfología, funcionalidad de la membrana e integridad del acrosoma. Para evaluar la tasa de preñez se inseminaron 20 yeguas. Se observó que la adición de Lcarnitina y piruvato en el semen equino no mejoró los resultados de movilidad progresiva ni demás parámetros cinemáticos. El porcentaje de espermatozoides con acrosoma/HOS positivo, el porcentaje de espermatozoides vivos con acrosoma intacto y el porcentaje de espermatozoides normales fueron significativamente mayores en las muestras con L-carnitina y piruvato. Por otro lado, no se observaron mejoras en la tasa de preñez en comparación a la obtenida usando el semen del grupo control pos-descongelado.\

JORNADAS DE INVESTIGACIÓN DE LA FACULTAD DE INGENIERÍA.JIFI-2006

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