25 research outputs found
Characterization of nucleic acid higher order structure by high-resolution tandem mass spectrometry
Intramolecular base-backbone association in 8-bromo-2',3'-O-isopropylidene-adenosine : detection of an O(5')-H...N(3) hydrogen bond via a long range H(5'')-N(3) spin-spin coupling
A completely rigid conformation is found for the syn-nucleoside 8-bromo-2,3-O-isopropylidene-adenosine in apolar solvents, which is due to an effective O(5)–H N(3) hydrogen bond, as is demonstrated by a substantial N(3) quadrupolar broadening of the H(5) resonances in the 1H n.m.r. spectra