10 research outputs found
The influence of addition of a catalyst and chelating agent on the properties of titanium dioxide synthesized via the sol–gel method
Get PDFEnhancement of plasma protein adsorption and osteogenesis of hMSCs by functionalized siloxane coatings for titanium implants
No full textCytotoxicity of Silica Nanoparticles with Transcaucasian Nose-Horned Viper, Vipera ammodytes transcaucasiana, Venom on U87MG and SHSY5Y Neuronal Cancer Cells
No full textSynthesis, Characterization and Bioactivity of Fluoride Containing Borosilicate Glass Matrix Composite
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Crystallization and luminescence properties of various Eu3+ content doped Al2O3 prepared by sol–gel method
No full textBiological characterization of a new silicon based coating developed for dental implants
No full textA common variant near TGFBR3 is associated with primary open angle glaucoma
No full textPrimary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European descent. Apart from confirming strong evidence of association at CDKN2B-AS1 (rs2157719 [G], odds ratio [OR] = 0.71, P = 2.81 Ă— 10(-33)), we observed one SNP showing significant association to POAG (CDC7-TGFBR3 rs1192415, ORG-allele = 1.13, Pmeta = 1.60 Ă— 10(-8)). This particular SNP has previously been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio, which are regarded as glaucoma-related quantitative traits. Our study now extends this by directly implicating it in POAG disease pathogenesis
