84 research outputs found
State Transfer Between a Mechanical Oscillator and Microwave Fields in the Quantum Regime
Recently, macroscopic mechanical oscillators have been coaxed into a regime
of quantum behavior, by direct refrigeration [1] or a combination of
refrigeration and laser-like cooling [2, 3]. This exciting result has
encouraged notions that mechanical oscillators may perform useful functions in
the processing of quantum information with superconducting circuits [1, 4-7],
either by serving as a quantum memory for the ephemeral state of a microwave
field or by providing a quantum interface between otherwise incompatible
systems [8, 9]. As yet, the transfer of an itinerant state or propagating mode
of a microwave field to and from a mechanical oscillator has not been
demonstrated owing to the inability to agilely turn on and off the interaction
between microwave electricity and mechanical motion. Here we demonstrate that
the state of an itinerant microwave field can be coherently transferred into,
stored in, and retrieved from a mechanical oscillator with amplitudes at the
single quanta level. Crucially, the time to capture and to retrieve the
microwave state is shorter than the quantum state lifetime of the mechanical
oscillator. In this quantum regime, the mechanical oscillator can both store
and transduce quantum information
The phytase RipBL1 enables the assignment of a specific inositol phosphate isomer as a structural component of human kidney stones
Inositol phosphates (InsPs) are ubiquitous in all eukaryotes. However, since there are 63 possible different phosphate ester isomers, the analysis of InsPs is challenging. In particular, InsP1, InsP2, and InsP3 already amass 41 different isomers, of which some occur as enantiomers. Profiling of these “lower” inositol phosphates in mammalian tissues requires powerful analytical methods and reference compounds. Here, we report an analysis of InsP2 and InsP3 with capillary electrophoresis coupled to electrospray ionization mass spectrometry (CE-ESI-MS). Using this method, the bacterial effector RipBL1 was analyzed and found to degrade InsP6 to Ins(1,2,3)P3, an understudied InsP3 isomer. This new reference molecule then aided us in the assignment of the isomeric identity of an InsP3 while profiling human samples: in urine and kidney stones, we describe for the first time the presence of defined and abundant InsP3 isomers, namely Ins(1,2,3)P3, Ins(1,2,6)P3 and/or Ins(2,3,4)P
Ultrasensitive force and displacement detection using trapped ions
The ability to detect extremely small forces is vital for a variety of
disciplines including precision spin-resonance imaging, microscopy, and tests
of fundamental physical phenomena. Current force-detection sensitivity limits
have surpassed 1 (atto ) through coupling of micro or
nanofabricated mechanical resonators to a variety of physical systems including
single-electron transistors, superconducting microwave cavities, and individual
spins. These experiments have allowed for probing studies of a variety of
phenomena, but sensitivity requirements are ever-increasing as new regimes of
physical interactions are considered. Here we show that trapped atomic ions are
exquisitely sensitive force detectors, with a measured sensitivity more than
three orders of magnitude better than existing reports. We demonstrate
detection of forces as small as 174 (yocto ), with a
sensitivity 390 using crystals of Be
ions in a Penning trap. Our technique is based on the excitation of normal
motional modes in an ion trap by externally applied electric fields, detection
via and phase-coherent Doppler velocimetry, which allows for the discrimination
of ion motion with amplitudes on the scale of nanometers. These experimental
results and extracted force-detection sensitivities in the single-ion limit
validate proposals suggesting that trapped atomic ions are capable of detecting
of forces with sensitivity approaching 1 . We anticipate that
this demonstration will be strongly motivational for the development of a new
class of deployable trapped-ion-based sensors, and will permit scientists to
access new regimes in materials science.Comment: Expanded introduction and analysis. Methods section added. Subject to
press embarg
T-staging of rectal cancer: accuracy of 3.0 Tesla MRI compared with 1.5 Tesla
OBJECTIVES: Magnetic resonance imaging (MRI) is not accurate in discriminating T1-2 from borderline T3 rectal tumors. Higher resolution on 3 Tesla-(3T)-MRI could improve diagnostic performance for T-staging. The aim of this study was to determine whether 3T-MRI compared with 1.5 Tesla-(1.5T)-MRI improves the accuracy for the discrimination between T1-2 and borderline T3 rectal tumors and to evaluate reproducibility. METHODS: 13 patients with non-locally advanced rectal cancer underwent imaging with both 1.5T and 3T-MRI. Three readers with different expertise evaluated the images and predicted T-stage with a confidence level score. Receiver operator characteristics curves with areas under the curve (AUC) and diagnostic parameters were calculated. Inter- and intra-observer agreements were calculated with quadratic kappa-weighting. Histology was the reference standard. RESULTS: Seven patients had pT1-2 tumors and six had pT3 tumors. AUCs ranged from 0.66 to 0.87 at 1.5T vs. 0.52-0.82 at 3T. Mean overstaging rate was 43% at 1.5T and 57% at 3T (P = 0.23). Inter-observer agreement was kappa 0.50-0.71 at 1.5T vs. 0.15-0.68 at 3T. Intra-observer agreement was kappa 0.71 at 1.5T and 0.76 at 3T. CONCLUSIONS: This is the first study to compare 3T with 1.5T MRI for T-staging of rectal cancer within the same patients. Our results showed no difference between 3T and 1.5T-MRI for the distinction between T1-2 and borderline T3 tumors, regardless of expertise. The higher resolution at 3T-MRI did not aid in the distinction between desmoplasia in T1-2-tumors and tumor stranding in T3-tumors. Larger studies are needed to acknowledge these findings
Multimode circuit optomechanics near the quantum limit
The coupling of distinct systems underlies nearly all physical phenomena and
their applications. A basic instance is that of interacting harmonic
oscillators, which gives rise to, for example, the phonon eigenmodes in a
crystal lattice. Particularly important are the interactions in hybrid quantum
systems consisting of different kinds of degrees of freedom. These assemblies
can combine the benefits of each in future quantum technologies. Here, we
investigate a hybrid optomechanical system having three degrees of freedom,
consisting of a microwave cavity and two micromechanical beams with closely
spaced frequencies around 32 MHz and no direct interaction. We record the first
evidence of tripartite optomechanical mixing, implying that the eigenmodes are
combinations of one photonic and two phononic modes. We identify an asymmetric
dark mode having a long lifetime. Simultaneously, we operate the nearly
macroscopic mechanical modes close to the motional quantum ground state, down
to 1.8 thermal quanta, achieved by back-action cooling. These results
constitute an important advance towards engineering entangled motional states.Comment: 6+7 page
An Atomic-resolution nanomechanical mass sensor
Mechanical resonators are widely used as inertial balances to detect small
quantities of adsorbed mass through shifts in oscillation frequency[1].
Advances in lithography and materials synthesis have enabled the fabrication of
nanoscale mechanical resonators[2, 3, 4, 5, 6], which have been operated as
precision force[7], position[8, 9] and mass sensors[10, 11, 12, 13, 14, 15].
Here we demonstrate a room-temperature, carbon-nanotube-based nanomechanical
resonator with atomic mass resolution. This device is essentially a mass
spectrometer with a mass sensitivity of 1.3 times 10^-25 kg Hz^-1/2 or,
equivalently, 0.40 gold atoms Hz^-1/2. Using this extreme mass sensitivity, we
observe atomic mass shot noise, which is analogous to the electronic shot
noise[16, 17] measured in many semiconductor experiments. Unlike traditional
mass spectrometers, nanomechanical mass spectrometers do not require the
potentially destructive ionization of the test sample, are more sensitive to
large molecules, and could eventually be incorporated on a chip
Nanomechanical motion measured with precision beyond the standard quantum limit
Nanomechanical oscillators are at the heart of ultrasensitive detectors of
force, mass and motion. As these detectors progress to even better sensitivity,
they will encounter measurement limits imposed by the laws of quantum
mechanics. For example, if the imprecision of a measurement of an oscillator's
position is pushed below the standard quantum limit (SQL), quantum mechanics
demands that the motion of the oscillator be perturbed by an amount larger than
the SQL. Minimizing this quantum backaction noise and nonfundamental, or
technical, noise requires an information efficient measurement. Here we
integrate a microwave cavity optomechanical system and a nearly noiseless
amplifier into an interferometer to achieve an imprecision below the SQL. As
the microwave interferometer is naturally operated at cryogenic temperatures,
the thermal motion of the oscillator is minimized, yielding an excellent force
detector with a sensitivity of 0.51 aN/rt(Hz). In addition, the demonstrated
efficient measurement is a critical step towards entangling mechanical
oscillators with other quantum systems.Comment: 5 pages, 4 figure
Demonstration of an ultracold micro-optomechanical oscillator in a cryogenic cavity
Preparing and manipulating quantum states of mechanical resonators is a
highly interdisciplinary undertaking that now receives enormous interest for
its far-reaching potential in fundamental and applied science. Up to now, only
nanoscale mechanical devices achieved operation close to the quantum regime. We
report a new micro-optomechanical resonator that is laser cooled to a level of
30 thermal quanta. This is equivalent to the best nanomechanical devices,
however, with a mass more than four orders of magnitude larger (43 ng versus 1
pg) and at more than two orders of magnitude higher environment temperature (5
K versus 30 mK). Despite the large laser-added cooling factor of 4,000 and the
cryogenic environment, our cooling performance is not limited by residual
absorption effects. These results pave the way for the preparation of 100-um
scale objects in the quantum regime. Possible applications range from
quantum-limited optomechanical sensing devices to macroscopic tests of quantum
physics.Comment: Published versio
Back-action Evading Measurements of Nanomechanical Motion
When performing continuous measurements of position with sensitivity
approaching quantum mechanical limits, one must confront the fundamental
effects of detector back-action. Back-action forces are responsible for the
ultimate limit on continuous position detection, can also be harnessed to cool
the observed structure, and are expected to generate quantum entanglement.
Back-action can also be evaded, allowing measurements with sensitivities that
exceed the standard quantum limit, and potentially allowing for the generation
of quantum squeezed states. We realize a device based on the parametric
coupling between an ultra-low dissipation nanomechanical resonator and a
microwave resonator. Here we demonstrate back-action evading (BAE) detection of
a single quadrature of motion with sensitivity 4 times the quantum zero-point
motion, back-action cooling of the mechanical resonator to n = 12 quanta, and a
parametric mechanical pre-amplification effect which is harnessed to achieve
position resolution a factor 1.3 times quantum zero-point motion.Comment: 19 pages (double-spaced) including 4 figures and reference
Oligonucleotide Frequencies of Barcoding Loci Can Discriminate Species across Kingdoms
Background: DNA barcoding refers to the use of short DNA sequences for rapid identification of species. Genetic distance or character attributes of a particular barcode locus discriminate the species. We report an efficient approach to analyze short sequence data for discrimination between species. Methodology and Principal Findings: A new approach, Oligonucleotide Frequency Range (OFR) of barcode loci for species discrimination is proposed. OFR of the loci that discriminates between species was characteristic of a species, i.e., the maxima and minima within a species did not overlap with that of other species. We compared the species resolution ability of different barcode loci using p-distance, Euclidean distance of oligonucleotide frequencies, nucleotide-character based approach and OFR method. The species resolution by OFR was either higher or comparable to the other methods. A short fragment of 126 bp of internal transcribed spacer region in ribosomal RNA gene was sufficient to discriminate a majority of the species using OFR. Conclusions/Significance: Oligonucleotide frequency range of a barcode locus can discriminate between species. Ability to discriminate species using very short DNA fragments may have wider applications in forensic and conservation studies
- …