39 research outputs found
d-Cycloserine adjuvant therapy to conventional neuroleptic treatment in schizophrenia: an open-label study
Differences in the time course of dopaminergic supersensitivity following chronic administration of haloperidol, molindone, or sulpiride
No personalization without participation: on the active contribution of psychiatric patients to the development of a mobile application for mental health
Insights into cognitive aging and Alzheimer’s disease using amyloid PET and structural MRI scans
Positron emission tomography using amyloid binding ligands, labeled with carbon-11 and fluorine-18, (Amyloid PET) has been used to understand the relationship between amyloid deposition in the brain, neurodegeneration and the development of mild cognitive impairment and dementia. Structural MRI has been used to identify morphological changes in the brain which may relate to the cause(s) of cognitive impairment, including infarcts, space-occupying lesions, hydrocephalus and the patterns of atrophy which are characteristic of various neurodegenerative diseases. These two imaging biomarkers have also played an important role in revealing the sequence of cerebral amyloid deposition, neurodegeneration and cognitive impairment. Although there may not be a direct relationship between amyloid deposition and brain atrophy or cognitive deficits, the presence of both amyloid deposition on PET and neurodegeneration on MRI has been associated with accelerated cognitive decline. The main focus of this article is to summarize some of the insights gained using these two imaging methods individually and in combination to better understand the biological bases of normal aging and age-associated cognitive impairment