Siete Partidas

Hay un ejemplar encuadernado con: "Las siete partidas del rey D. Alfonso el Sabio ". (XVIII/469); (XVIII/2776)Sign.: []1, [calderón]-2[calderón]2, A-Z4, Aa-Mm4Texto a dos colPort. con esc. xi

Characterization of the behavior of carotenoids from pitanga (Eugenia uniflora) and buriti (Mauritia flexuosa) during microemulsion production and in a dynamic gastrointestinal system

Uncommon tropical fruits are emerging as raw-material for new food products with health benefits. This work aimed at formulating and processing microemulsions from pitanga (Eugenia uniflora) and buriti (Mauritia flexuosa) fruits, since they are very rich in carotenoids (particularly lycopene and -carotene), in order to encapsulate and increase carotenoids bioaccessibility. Pitanga and buriti microemulsions were produced by applying a direct processing (high-speed homogenization at 15,000 rpm and ultrasound with 20 kHz probe at 40% amplitude) of the whole pulp together with surfactant (Tween 80 or Whey Protein Isolate at 2%) and corn oil (5%). All treatments (HSHUS for 04, 40, 44, 48 minmin) applied were able to increase the amount of carotenoid released. However, the processing also decreased the total amount of carotenoids in the whole pulp of studied fruits. The impact of processing during microemulsion production was not severe. The overall data suggest that the presence of surfactant and oil during processing may protect the carotenoids in fruits and microemulsions. Final recovery of total carotenoids, after passing the samples through a dynamic gastrointestinal system that simulates the human digestion, was higher for microemulsions than for whole pulps. High losses of total carotenoids in buriti and -carotene and lycopene in pitanga occurred during jejunum and ileum phases. The present work confirms that it is possible to increase -carotene and lycopene bioaccessibility from fruits by directly processing microemulsions (p<0.01).This work was supported by the São Paulo Research Foundation—FAPESP through research funding [Grant #2015/15507-9] and Ph.D. scholarship for Paulo Berni [Grant #2014/15119-6] and a Research Internships Abroad (BEPE) support [Grant #2016/13355-0]. The author Ana C. Pinheiro is recipient of a fellowship from the Portuguese Foundation for Science and Technology (FCT) [Grant SFRH/BPD/101181/2014]info:eu-repo/semantics/publishedVersio

A Functional Misexpression Screen Uncovers a Role for Enabled in Progressive Neurodegeneration

Drosophila is a well-established model to study the molecular basis of neurodegenerative diseases. We carried out a misexpression screen to identify genes involved in neurodegeneration examining locomotor behavior in young and aged flies. We hypothesized that a progressive loss of rhythmic activity could reveal novel genes involved in neurodegenerative mechanisms. One of the interesting candidates showing progressive arrhythmicity has reduced enabled (ena) levels. ena down-regulation gave rise to progressive vacuolization in specific regions of the adult brain. Abnormal staining of pre-synaptic markers such as cystein string protein (CSP) suggest that axonal transport could underlie the neurodegeneration observed in the mutant. Reduced ena levels correlated with increased apoptosis, which could be rescued in the presence of p35, a general Caspase inhibitor. Thus, this mutant recapitulates two important features of human neurodegenerative diseases, i.e., vulnerability of certain neuronal populations and progressive degeneration, offering a unique scenario in which to unravel the specific mechanisms in an easily tractable organism

Advances in photonic quantum sensing

Quantum sensing has become a mature and broad field. It is generally related with the idea of using quantum resources to boost the performance of a number of practical tasks, including the radar-like detection of faint objects, the readout of information from optical memories or fragile physical systems, and the optical resolution of extremely close point-like sources. Here we first focus on the basic tools behind quantum sensing, discussing the most recent and general formulations for the problems of quantum parameter estimation and hypothesis testing. With this basic background in our hands, we then review emerging applications of quantum sensing in the photonic regime both from a theoretical and experimental point of view. Besides the state-of-the-art, we also discuss open problems and potential next steps.Comment: Review in press on Nature Photonics. This is a preliminary version to be updated after publication. Both manuscript and reference list will be expande

Siete Partidas

Hay un ejemplar encuadernado con: Las siete partidas del rey D. Alfonso el Sabio (NP34/3).Sign.: []1, [calderon]-2[calderon]2, A-Z4, 2A-2M4, 2N3Texto a dos colPort. con esc. xil

Siete Partidas

Hay un ejemplar encuadernado con el volumen facticio XVIII/2778Mención de parte consta al final de port.Sign. : [calderon]-2 [calderon]2, 3 [calderon]1, A-Z4, 2A-2K4, 2L3Port. con esc. xilTexto a dos col. con notas a pie de pág. y apostillas marginalesInic. cabecera y final grab. xil

Siete Partidas

Hay un ejemplar encuadernado con: Las siete partidas del rey D. Alfonso el Sabio (NP34/3).Hay 1 ejemp. encuadernado con: "Las siete partidas del rey D. Alfonso el Sabio ...; partida sexta" (XVIII/2779)Mención de ed. precede a mención de partidaSign. : []1, [calderon]-2 [calderon]2, 3[calderon]1, A-Z4, 2A-2H4, 2I2Texto a dos colPort. con esc. xi

Siete Partidas

Hay un ejemplar encuadernado con: Las siete partidas del rey D. Alfonso el Sabio (NP34/3).Hay 1 ejemp. encuadernado con: "Las siete partidas del rey D. Alfonso el Sabio ...; partida sexta" (XVIII/2779)Mención de ed. precede a mención de partidaSign. : []1, [calderon]-2 [calderon]2, 3[calderon]1, A-Z4, 2A-2H4, 2I2Texto a dos colPort. con esc. xi