888 research outputs found
Shaping Intrinsic Neural Oscillations with Periodic Stimulation.
Rhythmic brain activity plays an important role in neural processing and behavior. Features of these oscillations, including amplitude, phase, and spectrum, can be influenced by internal states (e.g., shifts in arousal, attention or cognitive ability) or external stimulation. Electromagnetic stimulation techniques such as transcranial magnetic stimulation, transcranial direct current stimulation, and transcranial alternating current stimulation are used increasingly in both research and clinical settings. Currently, the mechanisms whereby time-dependent external stimuli influence population-scale oscillations remain poorly understood. Here, we provide computational insights regarding the mapping between periodic pulsatile stimulation parameters such as amplitude and frequency and the response dynamics of recurrent, nonlinear spiking neural networks. Using a cortical model built of excitatory and inhibitory neurons, we explored a wide range of stimulation intensities and frequencies systematically. Our results suggest that rhythmic stimulation can form the basis of a control paradigm in which one can manipulate the intrinsic oscillatory properties of driven networks via a plurality of input-driven mechanisms. Our results show that, in addition to resonance and entrainment, nonlinear acceleration is involved in shaping the rhythmic response of our modeled network. Such nonlinear acceleration of spontaneous and synchronous oscillatory activity in a neural network occurs in regimes of intense, high-frequency rhythmic stimulation. These results open new perspectives on the manipulation of synchronous neural activity for basic and clinical research.
Oscillatory activity is widely recognized as a core mechanism for information transmission within and between brain circuits. Noninvasive stimulation methods can shape this activity, something that is increasingly capitalized upon in basic research and clinical practice. Here, we provide computational insights on the mechanistic bases for such effects. Our results show that rhythmic stimulation forms the basis of a control paradigm in which one can manipulate the intrinsic oscillatory properties of driven networks via a plurality of input-driven mechanisms. In addition to resonance and entrainment, nonlinear acceleration is involved in shaping the rhythmic response of our modeled network, particularly in regimes of high-frequency rhythmic stimulation. These results open new perspectives on the manipulation of synchronous neural activity for basic and clinical research
The anapole moment and nucleon weak interactions
From the recent measurement of parity nonconservation (PNC) in the Cs atom we
have extracted the constant of the nuclear spin dependent electron-nucleon PNC
interaction, ; the anapole moment constant, ; the strength of the PNC proton-nucleus potential, ; the -meson-nucleon interaction constant,
; and the strength of the neutron-nucleus potential, .Comment: Uses RevTex, 12 pages. We have added an explanation of the effect of
finite nuclear siz
The Horizontal Component of Photospheric Plasma Flows During the Emergence of Active Regions on the Sun
The dynamics of horizontal plasma flows during the first hours of the
emergence of active region magnetic flux in the solar photosphere have been
analyzed using SOHO/MDI data. Four active regions emerging near the solar limb
have been considered. It has been found that extended regions of Doppler
velocities with different signs are formed in the first hours of the magnetic
flux emergence in the horizontal velocity field. The flows observed are
directly connected with the emerging magnetic flux; they form at the beginning
of the emergence of active regions and are present for a few hours. The Doppler
velocities of flows observed increase gradually and reach their peak values
4-12 hours after the start of the magnetic flux emergence. The peak values of
the mean (inside the +/-500 m/s isolines) and maximum Doppler velocities are
800-970 m/s and 1410-1700 m/s, respectively. The Doppler velocities observed
substantially exceed the separation velocities of the photospheric magnetic
flux outer boundaries. The asymmetry was detected between velocity structures
of leading and following polarities. Doppler velocity structures located in a
region of leading magnetic polarity are more powerful and exist longer than
those in regions of following polarity. The Doppler velocity asymmetry between
the velocity structures of opposite sign reaches its peak values soon after the
emergence begins and then gradually drops within 7-12 hours. The peak values of
asymmetry for the mean and maximal Doppler velocities reach 240-460 m/s and
710-940 m/s, respectively. An interpretation of the observable flow of
photospheric plasma is given.Comment: 20 pages, 10 figures, 3 tables. The results of article were presented
at the ESPM-13 (12-16 September 2011, Rhodes, Greece, Abstract Book p. 102,
P.4.12,
http://astro.academyofathens.gr/espm13/documents/ESPM13_abstract_programme_book.pdf
Transformation of Trojans into Quasi-Satellites During Planetary Migration and Their Subsequent Close-Encounters with the Host Planet
We use numerical integrations to investigate the dynamical evolution of
resonant Trojan and quasi-satellite companions during the late stages of
migration of the giant planets Jupiter, Saturn, Uranus, and Neptune. Our
migration simulations begin with Jupiter and Saturn on orbits already well
separated from their mutual 2:1 mean-motion resonance. Neptune and Uranus are
decoupled from each other and have orbital eccentricities damped to near their
current values. From this point we adopt a planet migration model in which the
migration speed decreases exponentially with a characteristic timescale tau
(the e-folding time). We perform a series of numerical simulations, each
involving the migrating giant planets plus test particle Trojans and
quasi-satellites. We find that the libration frequencies of Trojans are similar
to those of quasi-satellites. This similarity enables a dynamical exchange of
objects back and forth between the Trojan and quasi-satellite resonances during
planetary migration. Furthermore, under the influence of these secondary
resonances quasi-satellites can have their libration amplitudes enlarged until
they undergo a close-encounter with their host planet and escape from the
resonance. High-resolution simulations of this escape process reveal that ~80%
of Jovian quasi-satellites experience one or more close-encounters within
Jupiter's Hill radius (R_H) as they are forced out of the quasi-satellite
resonance. As many as ~20% come within R_H/4 and ~2.5% come within R_H/10.
Close-encounters of escaping quasi-satellites occur near or even below the
2-body escape velocity from the host planet
Randomised controlled trial to evaluate the effect of foot trimming before and after first calving on subsequent lameness episodes and productivity in dairy heifers
The objective of this study was to assess both independent and combined effects of routine foot trimming of heifers at 3 weeks pre-calving and 100 days post calving on the first lactation lameness and lactation productivity. A total of 419 pre-calving dairy heifers were recruited from one heifer rearing operation over a 10-month period. Heifers were randomly allocated into one of four foot trimming regimens; pre-calving foot trim and post-calving lameness score (Group TL), pre-calving lameness score and post-calving foot trim (Group LT), pre-calving foot trim and post-calving foot trim (Group TT), and pre-calving lameness score and post-calving lameness score (Group LL, control group). All heifers were scored for lameness at 24 biweekly time points for 1 year following calving, and first lactation milk production data were collected.
Following calving, 172/419 (41.1%) of heifers became lame during the study (period prevalence), with lameness prevalence at each time-point following calving ranging from 48/392 (12.2%) at 29–42 days post-calving to 4/379 (1.1%) between 295 and 383 days after calving. The effects of the four treatment groups were not significantly different from each other for overall lameness period prevalence, biweekly lameness point prevalence, time to first lameness event, type of foot lesion identified at dry off claw trimming, or the 4% fat corrected 305-day milk yield. However, increased odds lameness was significantly associated with a pre-calving trim alone (P = 0.044) compared to the reference group LL. The odds of heifer lameness were highest between 0 and 6 weeks post-partum, and heifer farm destination was significantly associated with lameness (OR 2.24), suggesting that even at high standard facilities, environment and management systems have more effect on heifer foot health than trimming
Evolution of whole-body enantiomorphy in the tree snail genus Amphidromus
Diverse animals exhibit left–right asymmetry in development. However, no example of dimorphism for the left–right polarity of development (whole-body enantiomorphy) is known to persist within natural populations. In snails, whole-body enantiomorphs have repeatedly evolved as separate species. Within populations, however, snails are not expected to exhibit enantiomorphy, because of selection against the less common morph resulting from mating disadvantage. Here we present a unique example of evolutionarily stable whole-body enantiomorphy in snails. Our molecular phylogeny of South-east Asian tree snails in the genus Amphidromus indicates that enantiomorphy has likely persisted as the ancestral state over a million generations. Enantiomorphs have continuously coexisted in every population surveyed spanning a period of 10 years. Our results indicate that whole-body enantiomorphy is maintained within populations opposing the rule of directional asymmetry in animals. This study implicates the need for explicit approaches to disclosure of a maintenance mechanism and conservation of the genus
Ecological Invasion, Roughened Fronts, and a Competitor's Extreme Advance: Integrating Stochastic Spatial-Growth Models
Both community ecology and conservation biology seek further understanding of
factors governing the advance of an invasive species. We model biological
invasion as an individual-based, stochastic process on a two-dimensional
landscape. An ecologically superior invader and a resident species compete for
space preemptively. Our general model includes the basic contact process and a
variant of the Eden model as special cases. We employ the concept of a
"roughened" front to quantify effects of discreteness and stochasticity on
invasion; we emphasize the probability distribution of the front-runner's
relative position. That is, we analyze the location of the most advanced
invader as the extreme deviation about the front's mean position. We find that
a class of models with different assumptions about neighborhood interactions
exhibit universal characteristics. That is, key features of the invasion
dynamics span a class of models, independently of locally detailed demographic
rules. Our results integrate theories of invasive spatial growth and generate
novel hypotheses linking habitat or landscape size (length of the invading
front) to invasion velocity, and to the relative position of the most advanced
invader.Comment: The original publication is available at
www.springerlink.com/content/8528v8563r7u2742
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