Deconstructing Decoherence

The study of environmentally induced superselection and of the process of decoherence was originally motivated by the search for the emergence of classical behavior out of the quantum substrate, in the macroscopic limit. This limit, and other simplifying assumptions, have allowed the derivation of several simple results characterizing the onset of environmentally induced superselection; but these results are increasingly often regarded as a complete phenomenological characterization of decoherence in any regime. This is not necessarily the case: The examples presented in this paper counteract this impression by violating several of the simple ``rules of thumb''. This is relevant because decoherence is now beginning to be tested experimentally, and one may anticipate that, in at least some of the proposed applications (e.g., quantum computers), only the basic principle of ``monitoring by the environment'' will survive. The phenomenology of decoherence may turn out to be significantly different.Comment: 13 two-column pages, 3 embedded figure

Quantum Computing with Trapped Ion Hyperfine Qubits

We discuss the basic aspects of quantum information processing with trapped ions, including the principles of ion trapping, preparation and detection of hyperfine qubits, single-qubit operations and multi-qubit entanglement protocols. Recent experimental advances and future research directions are outlined.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45527/1/11128_2004_Article_489417.pd

Proteogenomic analysis of human colon cancer reveals new therapeutic opportunities

We performed the first proteogenomic study on a prospectively collected colon cancer cohort. Comparative proteomic and phosphoproteomic analysis of paired tumor and normal adjacent tissues produced a catalog of colon cancer-associated proteins and phosphosites, including known and putative new biomarkers, drug targets, and cancer/testis antigens. Proteogenomic integration not only prioritized genomically inferred targets, such as copy-number drivers and mutation-derived neoantigens, but also yielded novel findings. Phosphoproteomics data associated Rb phosphorylation with increased proliferation and decreased apoptosis in colon cancer, which explains why this classical tumor suppressor is amplified in colon tumors and suggests a rationale for targeting Rb phosphorylation in colon cancer. Proteomics identified an association between decreased CD8 T cell infiltration and increased glycolysis in microsatellite instability-high (MSI-H) tumors, suggesting glycolysis as a potential target to overcome the resistance of MSI-H tumors to immune checkpoint blockade. Proteogenomics presents new avenues for biological discoveries and therapeutic development

Track A Basic Science

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138319/1/jia218438.pd