Main-streaming participatory and cross-disciplinary approaches in animal science research in developing countries

Conventional research approaches have lost considerable momentum after their astonishing achieve-ments during the green revolution. The negative side of focusing rigorously on production improve-ment was eminent around 1980 and led to considerations of environmental, gender and equity aspects - making agricultural development much more complex than previously. In the search for new ways of addressing the persisting problems of food insecurity and malnutrition, new ways should be explored. Based on the experiences from three international, African research projects, the article argues the case of participatory action research and cross-disciplinarity as some of the key elements in future animal science research in developing countries. The benefits are outlined as well as the challenges for the researchers and the donor agencies

Microscopic Description of Black Rings in AdS/CFT

We discuss some aspects of the recently discovered BPS black ring solutions in terms of the AdS/CFT correspondence. In the type IIB frame in which the black ring carries the charges of the D1-D5-P system, we propose a microscopic description of the rings in the orbifold CFT governing this system. In our proposal, the CFT effectively splits into two parts: one part captures the supertube-like properties of the ring, and the other captures the entropy. We can also understand the black ring entropy by relating the geometry near the ring to BPS black holes in four dimensions, although this latter approach does not directly lead to an identification of black rings in terms of the D1-D5-P CFT.Comment: 18 pages, harvmac. v2 - minor typo

The Black Branes of M-theory

We present a class of black $p$-brane solutions of M-theory which were hitherto known only in the extremal supersymmetric limit, and calculate their macroscopic entropy and temperature.Comment: Latex, 13 pages, minor corrections and reference adde

Enhanced surface colonisation and competition during bacterial adaptation to a fungus

Microbial Biotechnolog

Identification of type 2 diabetes loci in 433,540 East Asian individuals

Meta-analyses of genome-wide association studies (GWAS) have identified more than 240 loci that are associated with type 2 diabetes (T2D)1,2; however, most of these loci have been identified in analyses of individuals with European ancestry. Here, to examine T2D risk in East Asian individuals, we carried out a meta-analysis of GWAS data from 77,418 individuals with T2D and 356,122 healthy control individuals. In the main analysis, we identified 301 distinct association signals at 183 loci, and across T2D association models with and without consideration of body mass index and sex, we identified 61 loci that are newly implicated in predisposition to T2D. Common variants associated with T2D in both East Asian and European populations exhibited strongly correlated effect sizes. Previously undescribed associations include signals in or near GDAP1, PTF1A, SIX3, ALDH2, a microRNA cluster, and genes that affect the differentiation of muscle and adipose cells3. At another locus, expression quantitative trait loci at two overlapping T2D signals affect two genes—NKX6-3 and ANK1—in different tissues4–6. Association studies in diverse populations identify additional loci and elucidate disease-associated genes, biology, and pathways

The trans-ancestral genomic architecture of glycemic traits

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 x 10(-8)), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.Diabetes mellitus: pathophysiological changes and therap

Isolation of brominated long-chain fatty acids from the phospholipids of the tropical marine sponge Amphimedon terpenensis

Preliminary investigation of the phospholipid fatty acid composition of the tropical marine sponge Amphimedon terpenensis by gas chromatography/mass spectrometry revealed the presence of some novel brominated fatty acids. Two new brominated fatty acids, (5 E, 9 Z)-6-bromo-5,9-tetracosadienoic acid (2a) and (5 E, 9 Z)-6-bromo-5,9-pentacosadienoic acid (3a) were subsequently isolated from a chloroform/methanol (3:1, vol/vol) extract of the sponge and characterized as their methyl esters 2b and 3b. The known brominated fatty acid (5 E, 9 Z)-6-bromo-5,9-hexacosadienoic acid (4a) was also isolated. The new fatty acid methyl esters were confirmed as brominated δ5,9 acid derivatives by chemical ionization mass spectrometry. The position of the bromine substituent was determined to be C-6 by nuclear magnetic resonance techniques while the stereochemistry of the two double bonds was deduced by nuclear Overhauser enhancement difference spectroscopy. The biosynthetic implications of the co-occurrence of the three brominated acids are discussed