55 research outputs found
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk
Preoperative ERCP in the Management of Common Bile Duct Stones before Laparoscopic Cholecystectomy
European Journal of Surgery1623205-210EUJS
Management of acute cholecystitis in the era of laparoscopic surgery
Annals of the Academy of Medicine Singapore255640-642AAMS
Laparoscopic Billroth II gastrectomy: A review
10.1016/0960-7404(93)90053-2Surgical Oncology2SUPPL. 113-18SUOC
Laparoscopic posterior truncal vagotomy and anterior highly selective vagotomy--a case report.
Singapore Medical Journal333302-30
Laparoscopic vagotomy: A new tool in the management of duodenal ulcer disease [9]
British Journal of Surgery799977-BJSU
Laparoscopic cholecystectomy: The Singapore experience
Surgical Laparoscopy and Endoscopy4122-24SLEN
Palliation of advanced gastric cancer by laparoscopic gastrojejunostomy.
Singapore Medical Journal362228-22
Deep vein thrombosis complicating colorectal surgery in the Chinese in Singapore.
Annals of the Academy of Medicine Singapore226895-89
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