263 research outputs found
Can murine diabetic nephropathy be separated from superimposed acute renal failure?
Can murine diabetic nephropathy be separated from superimposed acute renal failure?BackgroundStreptozotocin (STZ) is commonly used to induce diabetes in experimental animal models, but not without accompanying cytotoxic effects. This study was undertaken to (1) determine an optimal dose and administration route of STZ to induce diabetic nephropathy in wild-type mice but without the concurrent acute renal injury resulting from cytotoxic effects of STZ and (2) evaluate the pattern of tubular injury and interstitial inflammation in this model.MethodsMale Balb/c mice received either (1) STZ (225mg/kg by intraperitoneal injection.); or (2) two doses of STZ 5 days apart (150mg/150mg/kg; 75mg/150mg/kg; 75mg/75mg/kg; and 100mg/100mg/kg by intravenous injection). Another strain of mice, C57BL/6J, also received STZ (200mg/kg intravenously or intraperitoneally). Renal function and histology were examined at weeks 1, 2, 4, and 8 after induction of diabetes. In initial optimization studies, animals were sacrificed at week 1 or week 2 and histology examined for acute renal injury.ResultsFollowing a single intraperitoneal injection of 225mg/kg of STZ, only two thirds of animals developed hyperglycemia, yet the model was associated with focal areas of acute tubular necrosis (ATN) at week 2. ATN was also observed in C57BL/6J mice given a single intravenous or intraperitoneal dose of STZ (200mg/kg), at week 2 post-diabetes. At an optimal diabetogenic dose and route (75mg/150mg/kg by intravenous injection 5 days apart), all mice developed diabetes and no ATN was observed histologically. However, even with this regimen, glomerular filtration rate (GFR) was significantly impaired from week 2. This regimen was accompanied by progressive histologic changes, including tubular and glomerular hypertrophy, mesangial area expansion, as well as interstitial macrophage, CD4+ and CD8+ T-cell accumulation.ConclusionBy careful optimization of STZ dose, a stable and reproducible diabetic murine model was established. However, even in this optimized model, renal functional impairment was observed. The frequency of ATN and functional impairment casts doubt on conclusions about experimental diabetic nephropathy drawn from reports in which ATN has not been excluded rigorously
Resonance structures in the multichannel quantum defect theory for the photofragmentation processes involving one closed and many open channels
The transformation introduced by Giusti-Suzor and Fano and extended by
Lecomte and Ueda for the study of resonance structures in the multichannel
quantum defect theory (MQDT) is used to reformulate MQDT into the forms having
one-to-one correspondence with those in Fano's configuration mixing (CM) theory
of resonance for the photofragmentation processes involving one closed and many
open channels. The reformulation thus allows MQDT to have the full power of the
CM theory, still keeping its own strengths such as the fundamental description
of resonance phenomena without an assumption of the presence of a discrete
state as in CM.Comment: 7 page
Accounting for Slow J/psi from B Decay
A slow J/psi excess exists in the inclusive B -> J/psi+X spectrum, and is
indicative of some hadronic effect. From color octet nature of c cbar pair in
b-> c cbar s decay, one such possibility would be B -> J/psi+ K_g decay, where
K_g is a hybrid resonance with sbar g q constituents. We show that a K_g
resonance of ~ 2 GeV mass and suitably broad width could be behind the excess.Comment: 4 pages, 2 figures. To appear in Phys. Rev.
Symmetric Textures in SO(10) and LMA Solution for Solar Neutrinos
We analyze a model based on SUSY SO(10) combined with SU(2) family symmetry
and symmetric mass matrices constructed by the authors recently. Previously,
only the parameter space for the LOW and vacuum oscillation (VO) solutions was
investigated. We indicate in this note the parameter space which leads to large
mixing angle (LMA) solution to the solar neutrino problem with a slightly
modified effective neutrino mass matrix. The symmetric mass textures arising
from the left-right symmetry breaking and the SU(2) symmetry breaking give rise
to very good predictions for the quark and lepton masses and mixing angles. The
prediction of our model for the |U_{e\nu_{3}}| element in the
Maki-Nakagawa-Sakata (MNS) matrix is close to the sensitivity of current
experiments; thus the validity of our model can be tested in the near future.
We also investigate the correlation between the |U_{e\nu_{3}}| element and
\tan^{2}\theta_{\odot} in a general two-zero neutrino mass texture.Comment: RevTeX4; 9 pages; 1 figur
Four Light Neutrinos in Singular Seesaw Mechanism with Abelian Flavor Symmetry
The four light neutrino scenario, which explains the atmosphere, solar and
LSND neutrino experiments, is studied in the framework of the seesaw mechanism.
By taking both the Dirac and Majorana mass matrix of neutrinos to be singular,
the four neutrino mass spectrum consisting of two almost degenerate pairs
separated by a mass gap eV is naturally generated. Moreover the
right-handed neutrino Majorana mass can be at GeV scale unlike
in the usual singular seesaw mechanism. Abelian flavor symmetry is used to
produce the required neutrino mass pattern. A specific example of the flavor
charge assignment is provided to show that maximal mixings between the
and are respectively attributed to the
atmosphere and solar neutrino anomalies while small mixing between two pairs to
the LSND results. The implication in the other fermion masses is also
discussed.Comment: Firnal version to appear in PR
Finite element and experimental analyses of closure and contact bonding of pores during hot rolling of steel
The closure and contact bonding behavior of internal pores in steel slabs during hot rolling was studied using experiments and the finite element method (FEM). Effects of pore size and shape were investigated, and three different cases of pore closure results were observed: no closure, partial closure, and full closure. The FEM results well reproduced various closure events. Bonding strengths of unsuccessfully closed pores, measured by tensile tests, showed critical effects. Also, there was a difference in bonding strengths of several fully closed pores. Fracture surfaces showed that welded regions could be divided into three (not, partially, and perfectly) welded regions. The pressure-time curves obtained from the FEM results indicate that pore surface contact time and deformed surface length are important parameters in pore welding. Pore size, pore shape, time of pressure contact, and deformed surface length should be considered to completely eliminate pores in final products.ope
Collider signals from slow decays in supersymmetric models with an intermediate-scale solution to the mu problem
The problem of the origin of the mu parameter in the Minimal Supersymmetric
Standard Model can be solved by introducing singlet supermultiplets with
non-renormalizable couplings to the ordinary Higgs supermultiplets. The
Peccei-Quinn symmetry is broken at a scale which is the geometric mean between
the weak scale and the Planck scale, yielding a mu term of the right order of
magnitude and an invisible axion. These models also predict one or more singlet
fermions which have electroweak-scale masses and suppressed couplings to MSSM
states. I consider the case that such a singlet fermion, containing the axino
as an admixture, is the lightest supersymmetric particle. I work out the
relevant couplings in several of the simplest models of this type, and compute
the partial decay widths of the next-to-lightest supersymmetric particle
involving leptons or jets. Although these decays will have an average proper
decay length which is most likely much larger than a typical collider detector,
they can occasionally occur within the detector, providing a striking signal.
With a large sample of supersymmetric events, there will be an opportunity to
observe these decays, and so gain direct information about physics at very high
energy scales.Comment: 24 pages, LaTeX, 4 figure
Charge asymmetry ratio as a probe of quark flavour couplings of resonant particles at the LHC
We show how a precise knowledge of parton distribution functions, in
particular those of the u and d quarks, can be used to constrain a certain
class of New Physics models in which new heavy charged resonances couple to
quarks and leptons. We illustrate the method by considering a left-right
symmetric model with a W' from a SU(2)_R gauge sector produced in
quark-antiquark annihilation and decaying into a charged lepton and a heavy
Majorana neutrino. We discuss a number of quark and lepton mixing scenarios,
and simulate both signals and backgrounds in order to determine the size of the
expected charge asymmetry. We show that various quark-W' mixing scenarios can
indeed be constrained by charge asymmetry measurements at the LHC, particularly
at 14 TeV centre of mass energy.Comment: 14 pages, 3 figure
Charmless Two-body Baryonic B Decays
We study charmless two-body baryonic B decays in a diagramatic approach.
Relations on decay amplitudes are obtained. In general there are more than one
tree and more than one penguin amplitudes. The number of independent amplitudes
can be reduced in the large m_B limit. It leads to more predictive results.
Some prominent modes for experimental searches are pointed out.Comment: 15 pages, 2 figures. To appear in Phys. Rev.
A weakly stable algorithm for general Toeplitz systems
We show that a fast algorithm for the QR factorization of a Toeplitz or
Hankel matrix A is weakly stable in the sense that R^T.R is close to A^T.A.
Thus, when the algorithm is used to solve the semi-normal equations R^T.Rx =
A^Tb, we obtain a weakly stable method for the solution of a nonsingular
Toeplitz or Hankel linear system Ax = b. The algorithm also applies to the
solution of the full-rank Toeplitz or Hankel least squares problem.Comment: 17 pages. An old Technical Report with postscript added. For further
details, see http://wwwmaths.anu.edu.au/~brent/pub/pub143.htm
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