Amelioration of Hyperglycemia and Dyslipidemia in Alloxan-Induced Diabetic Rats Using Citrulluslanatus and Persea Americana

Dyslipidemia has been observed to play an integral role in the pathogenesis of micro and macrovascular complications in diabetes mellitus patients. The complications were assessed via atherogenic index (AI), Coronary risk index (CRI) and Cardiovascular risk index (CVRI).The study was to investigate the amelioration of hyperglycemia and dyslipidemia in alloxan induced rats using watermelon and avocado seeds. A total of Forty rats were divided into eight groups of 5 rats accordingly. Diabetes was induced with a single dose of alloxan (100mg/kg) body weight and serum glucose was taken 72h after induction of confirm diabetes. Amelioration of hyperglycemia and dyslipidemia started on the 6th and 9th day of the experiment respectively. The result obtained from the phytochemical analysis showed that the aqueous extract of Citrulluslanatus and Persea Americana gave positive reactions for Alkaliods, tannins, flavonoids and saponins. The data showed that Alloxan caused significant increase in Glucose, TC, TGs and LDL in the untreated diabetic rats. On the other hand HDL was significantly decreased. The result showed that Citrulluslanatus and Persea Americana seeds extracts significantly and progressively lowered the glucose level, TC, TGs and LDL dose dependently while significantly causing a dose-related elevation in HDL concentration. The result shows that atorvastatin and the seeds extracts are capable of reducing risk of AI, CRI and CVRI in diabetic rats

Antidiabetic and Antihyperlipidemic Effects of Aqueous Extract of Carica papaya Leaf on the Experimental Model against Single Alloxan Toxicity

Antidiabetic and antihyperlipidemic effects of aqueous extract of Carica papaya leaf on the toxicity were investigated. A total of thirty rats were divided into six groups of 5 rats: Group A: Normal control, Group B: Negative control, Group C: Positive control I, Group D: Positive control II, Group E: Test control I, Group F: Test control II. Diabetes was induced with a single dose of alloxan (120mg/kg) body weight and serum glucose was taken 72hrs after induction to confirm diabetes. The oral administration for hyperglycemia and hyperlipidemia started on the 4th and 8th day of the experiment respectively. The result showed that Carica papaya leaf extract significantly and progressively lowered the glucose level, TG, TC and LDL dose dependently while significantly causing a dose-related elevation in HDL concentration when compared to the untreated control and positive control groups (I & II) treated rats. Phytochemical analysis revealed the presence of alkaloids, flavonoids, saponins and tannins. The aqueous extract of this plant can be used to brew a tonic that will allay the metabolic disruption produced by diabetes