7 research outputs found

    Molecular characterization of autonomic and neuropeptide receptors

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    © 1994 by Marcel Dekker, Inc. All Rights Reserved. For many years, it was believed that the control of airway function was dependent on the balance between the cholinergic (parasympathetic) and adrenergic (sympathetic) nervous systems. The cholinergic system is considered excitatory because it plays a role in maintaining airway tone and in mediating acute bronchospastic responses (Casale, 1993). The effect of acetylcholine to produce narrowing of the airways is blocked by atropine, indicating that this effect is mediated by muscarinic acetylcholine receptors (Colebatch and Halmagyi, 1963; Olsen et al., 1965). In contrast, the adrenergic system in the lung is considered inhibitory because stimulation of β-adrenergic receptors produces relaxation of bronchial smooth muscle. The beta-blockade theory of the pathogenesis of asthma from Szentivanyi (1968) proposed that asthma was related to an imbalance in the autonomic control of airway diameter due to a decrease in β-adrenergic sensitivity in bronchial smooth muscle, mucus glands, and mucosal blood vessels

    Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

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    Correction to: Nature Genetics https://doi.org/10.1038/s41588-021-00973-1, published online 6 December 2021. In the version of this article initially published, the affiliation for Nazli Başak appeared incorrectly. Nazli Başak is at Koç University, School of Medicine, KUTTAM-NDAL, Istanbul, Turkey, and not Bogazici University. The error has been corrected in the HTML and PDF versions of the article
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