Availability Analysis of Chemicals for Water Treatment: An Application to Edo and Anambra State Water Utilities Boards

In most countries, chemicals are generally recognized as being vital in the production of potable water and will normally be required in large quantities in water treatment facilitates. Although some developing countries have local chemical production capabilities, the majority of them still have to import the chemicals from industrialized countries. This paper considers the shipment of regular supplies of large quantities of chemicals used in treating water to potable standard in a developing country. A model to reduce the shortage of chemicals for water treatment while minimizing the direct costs of supplying the chemicals for water treatment while minimizing the direct costs of supplying the contractors or manufacturers is represented as a network composed of interconnected geographical regions. Edo and Anambra States are used as case studies. Objectives are achieved considering the uncertainty in future supply of chemicals for water treatment in Nigeria. The time horizon of the model is between 1 and 5 years. Estimates of future demands and supplies of chemicals and the associated costs are used as endogenous and exogenous parameters in the model. The model should assist water utility decision makers during current and subsequent periods in order to determine an optimal policy for uninterrupted supply of chemicals required at the treatment plants at minimum cost

Issues with the Measurement of Informal Care in Social Surveys: Evidence from the English Longitudinal Study of Ageing

Informal care plays a significant role in the care system for older people in the United Kingdom, and this is projected to increase considerably in the next three decades as the population ages. Understanding these trends requires a good quality measurement of informal care. In this study, we compare care givers’ responses to different informal care questions from the English Longitudinal Study of Ageing (ELSA) to investigate the influence of question design on the self-reporting of informal care. We also analyse spousal care dyads in order to model discrepancies in the reporting of care provision between spouses to provide an insight into the reliability of informal care measurements. We find that the most common measures used are likely to be under-estimating both the scale and scope of informal care, and we recommend careful consideration of the content of informal care survey questions in order to operationalise the measures of informal care activities

TYK2 promotes malignant peripheral nerve sheath tumor progression through inhibition of cell death

BACKGROUND: Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas that arise most commonly in the setting of the Neurofibromatosis Type 1 (NF1) cancer predisposition syndrome. Despite aggressive multimodality therapy, outcomes are dismal and most patients die within 5 years of diagnosis. Prior genomic studies in our laboratory identified tyrosine kinase 2 (TYK2) as a frequently mutated gene in MPNST. Herein, we explored the function of TYK2 in MPNST pathogenesis. METHODS: Immunohistochemistry was utilized to examine expression of TYK2 in MPNSTs and other sarcomas. To establish a role for TYK2 in MPNST pathogenesis, murine and human TYK2 knockdown and knockout cells were established using shRNA and CRISPR/Cas9 systems, respectively. RESULTS: We have demonstrated that TYK2 was highly expressed in the majority of human MPNSTs examined. Additionally, we demonstrated that knockdown of Tyk2/TYK2 in murine and human MPNST cells significantly increased cell death in vitro. These effects were accompanied by a decrease in the levels of activated Stats and Bcl-2 as well as an increase in the levels of Cleaved Caspase-3. In addition, Tyk2-KD cells demonstrated impaired growth in subcutaneous and metastasis models in vivo. CONCLUSION: Taken together, these data illustrate the importance of TYK2 in MPNST pathogenesis and suggest that the TYK2 pathway may be a potential therapeutic target for these deadly cancers

Understanding the internet topology evolution dynamics

The internet structure is extremely complex. The Positive-Feedback Preference (PFP) model is a recently introduced internet topology generator. The model uses two generic algorithms to replicate the evolution dynamics observed on the internet historic data. The phenomenological model was originally designed to match only two topology properties of the internet, i.e. the rich-club connectivity and the exact form of degree distribution. Whereas numerical evaluation has shown that the PFP model accurately reproduces a large set of other nontrivial characteristics as well. This paper aims to investigate why and how this generative model captures so many diverse properties of the internet. Based on comprehensive simulation results, the paper presents a detailed analysis on the exact origin of each of the topology properties produced by the model. This work reveals how network evolution mechanisms control the obtained topology properties and it also provides insights on correlations between various structural characteristics of complex networks.Comment: 15 figure

Pattern of Ultrasound Scanning in Owerri South Eastern Nigeria

BACKGROUND: The gynaecologist is called upon daily to diagnose pelvic pathologies. Ultrasound is a useful, safe and widely used method of investigation of such problems.OBJECTIVE: To determine the indications and findings of pelvic ultrasound in Owerri, South Eastern Nigeria.METHOD: Two hundred and fifty consecutive women referred for pelvic ultrasound in Owerri South Eastern Nigeria were examined by abdominal and transvaginal ultrasound.RESULTS: Most 148(59.2%) of the patients were nulliparous and majority 108(43.2%) were in the 30-39year age group. Doctors referred most 164(64%) of the patients, while 74(29.6%) were self referred. The most common indication was ‘to check the womb’ in 89(35.6%) of cases followed by threatened abortion in 30(12%) of patients. The most common post ultrasound diagnosis was ‘normal uterus’ in 111(44.4%) while fibromyoma was second with 41(16.4%) of patients. On the whole abnormalities were picked up in 36.4% of patients.CONCLUSION: We conclude that pelvic ultrasound even when not originating from the doctor should be encouraged because of the significant number of abnormalities detected. These could then be treated with greater success while they are still small

Feature Learning in Image Hierarchies using Functional Maximal Correlation

This paper proposes the Hierarchical Functional Maximal Correlation Algorithm (HFMCA), a hierarchical methodology that characterizes dependencies across two hierarchical levels in multiview systems. By framing view similarities as dependencies and ensuring contrastivity by imposing orthonormality, HFMCA achieves faster convergence and increased stability in self-supervised learning. HFMCA defines and measures dependencies within image hierarchies, from pixels and patches to full images. We find that the network topology for approximating orthonormal basis functions aligns with a vanilla CNN, enabling the decomposition of density ratios between neighboring layers of feature maps. This approach provides powerful interpretability, revealing the resemblance between supervision and self-supervision through the lens of internal representations

Systematic Topology Analysis and Generation Using Degree Correlations

We present a new, systematic approach for analyzing network topologies. We first introduce the dK-series of probability distributions specifying all degree correlations within d-sized subgraphs of a given graph G. Increasing values of d capture progressively more properties of G at the cost of more complex representation of the probability distribution. Using this series, we can quantitatively measure the distance between two graphs and construct random graphs that accurately reproduce virtually all metrics proposed in the literature. The nature of the dK-series implies that it will also capture any future metrics that may be proposed. Using our approach, we construct graphs for d=0,1,2,3 and demonstrate that these graphs reproduce, with increasing accuracy, important properties of measured and modeled Internet topologies. We find that the d=2 case is sufficient for most practical purposes, while d=3 essentially reconstructs the Internet AS- and router-level topologies exactly. We hope that a systematic method to analyze and synthesize topologies offers a significant improvement to the set of tools available to network topology and protocol researchers.Comment: Final versio

The Role of Solar Wind Hydrogen in Space Weathering: Insights from Laboratory-Irradiated Northwest Africa 12008

Micrometeoroid impacts, solar wind plasma interactions, and regolith gardening drive the complicated and nuanced mechanism of space weathering (or optical maturation); a process by which a materials optical properties are changed as a result of chemical and physical alterations at the surface of grains on airless bodies. Reddened slopes, attenuated absorption bands, and an overall reduction in albedo in the visible and near-IR wavelength ranges are primarily the result of native iron nanoparticle (npFe0) production within glassy rims that form from sputtering and vaporization. The sizes and abundance of these particles provide information about the relative surface exposure age of a particular grain. In addition, many studies have indicated that composition greatly affects the rate at which optical maturation occurs. Despite our understanding of how npFe0 affects optical signatures, the relative roles of micrometeoroid bombardment and solar wind interactions remains undetermined. To simulate the early effects of weathering by the solar wind and to determine thresholds for optical change with respect to a given mineral phase, we irradiated a fine-grained lunar basalt with 1 keV H+ to a fluence of 6.4 x 1016 H+ per sq.cm. Surface alterations within four phases have been evaluated using transmission electron microscopy (TEM). We found that for a given fluence of H+, the extent of damage acquired by each grain was dependent on its composition. No npFe(0) was produced in any of the phases evaluated in this study. These results are consistent with many previous studies conducted using ions of similar energy, but they also provide valuable information about the onset of space weathering and the role of the solar wind during the early stages of optical maturation

Antenatal Care Booking Pattern at a Tertiary Hospital in South- Eastern Nigeria

No Abstract

Clec9a-mediated ablation of conventional dendritic cells suggests a lymphoid path to generating dendritic cells In Vivo

Conventional dendritic cells (cDCs) are versatile activators of immune responses that develop as part of the myeloid lineage downstream of hematopoietic stem cells. We have recently shown that in mice precursors of cDCs, but not of other leukocytes, are marked by expression of DNGR-1/CLEC9A. To genetically deplete DNGR-1-expressing cDC precursors and their progeny, we crossed Clec9a-Cre mice to Rosa-lox-STOP-lox-diphtheria toxin (DTA) mice. These mice develop signs of age-dependent myeloproliferative disease, as has been observed in other DC-deficient mouse models. However, despite efficient depletion of cDC progenitors in these mice, cells with phenotypic characteristics of cDCs populate the spleen. These cells are functionally and transcriptionally similar to cDCs in wild type control mice but show somatic rearrangements of Ig-heavy chain genes, characteristic of lymphoid origin cells. Our studies reveal a previously unappreciated developmental heterogeneity of cDCs and suggest that the lymphoid lineage can generate cells with features of cDCs when myeloid cDC progenitors are impaired