Determination of wind tunnel constraint effects by a unified pressure signature method. Part 1: Applications to winged configurations

A new, fast, non-iterative version of the "Wall Pressure Signature Method" is described and used to determine blockage and angle-of-attack wind tunnel corrections for highly-powered jet-flap models. The correction method is complemented by the application of tangential blowing at the tunnel floor to suppress flow breakdown there, using feedback from measured floor pressures. This tangential blowing technique was substantiated by subsequent flow investigations using an LV. The basic tests on an unswept, knee-blown, jet flapped wing were supplemented to include the effects of slat-removal, sweep and the addition of unflapped tips. C sub mu values were varied from 0 to 10 free-air C sub l's in excess of 18 were measured in some cases. Application of the new methods yielded corrected data which agreed with corresponding large tunnel "free air" resuls to within the limits of experimental accuracy in almost all cases. A program listing is provided, with sample cases

Determination of wind tunnel constraint effects by a unified pressure signature method. Part 2: Application to jet-in-crossflow

The development of an improved jet-in-crossflow model for estimating wind tunnel blockage and angle-of-attack interference is described. Experiments showed that the simpler existing models fall seriously short of representing far-field flows properly. A new, vortex-source-doublet (VSD) model was therefore developed which employs curved trajectories and experimentally-based singularity strengths. The new model is consistent with existing and new experimental data and it predicts tunnel wall (i.e. far-field) pressures properly. It is implemented as a preprocessor to the wall-pressure-signature-based tunnel interference predictor. The supporting experiments and theoretical studies revealed some new results. Comparative flow field measurements with 1-inch "free-air" and 3-inch impinging jets showed that vortex penetration into the flow, in diameters, was almost unaltered until 'hard' impingement occurred. In modeling impinging cases, a 'plume redirection' term was introduced which is apparently absent in previous models. The effects of this term were found to be very significant

Sub-Nyquist Field Trial Using Time Frequency Packed DP-QPSK Super-Channel Within Fixed ITU-T Grid

Sub-Nyquist time frequency packing technique was demonstrated for the first time in a super channel field trial transmission over long-haul distances. The technique allows a limited spectral occupancy even with low order modulation formats. The transmission was successfully performed on a deployed Australian link between Sydney and Melbourne which included 995 km of uncompensated SMF with coexistent traffic. 40 and 100 Gb/s co-propagating channels were transmitted together with the super-channel in a 50 GHz ITU-T grid without additional penalty. The super-channel consisted of eight sub-channels with low-level modulation format, i.e. DP-QPSK, guaranteeing better OSNR robustness and reduced complexity with respect to higher order formats. At the receiver side, coherent detection was used together with iterative maximum-a-posteriori (MAP) detection and decoding. A 975 Gb/s DP-QPSK super-channel was successfully transmitted between Sydney and Melbourne within four 50GHz WSS channels (200 GHz). A maximum potential SE of 5.58 bit/s/Hz was achieved with an OSNR=15.8 dB, comparable to the OSNR of the installed 100 Gb/s channels. The system reliability was proven through long term measurements. In addition, by closing the link in a loop back configuration, a potential SE*d product of 9254 bit/s/Hz*km was achieved

Chiral Behaviour of the Rho Meson in Lattice QCD

In order to guide the extrapolation of the mass of the rho meson calculated in lattice QCD with dynamical fermions, we study the contributions to its self-energy which vary most rapidly as the quark mass approaches zero; from the processes $\rho \to \omega \pi$ and $\rho \to \pi \pi$. It turns out that in analysing the most recent data from CP-PACS it is crucial to estimate the self-energy from $\rho \to \pi \pi$ using the same grid of discrete momenta as included implicitly in the lattice simulation. The correction associated with the continuum, infinite volume limit can then be found by calculating the corresponding integrals exactly. Our error analysis suggests that a factor of 10 improvement in statistics at the lowest quark mass for which data currently exists would allow one to determine the physical rho mass to within 5%. Finally, our analysis throws new light on a long-standing problem with the J-parameter.Comment: 13 pages, 7 figures. Full analytic forms of the self-energies are included and a correction in the omega-pi self-energ

Physical boundary state for the quantum tetrahedron

We consider stability under evolution as a criterion to select a physical boundary state for the spinfoam formalism. As an example, we apply it to the simplest spinfoam defined by a single quantum tetrahedron and solve the associated eigenvalue problem at leading order in the large spin limit. We show that this fixes uniquely the free parameters entering the boundary state. Remarkably, the state obtained this way gives a correlation between edges which runs at leading order with the inverse distance between the edges, in agreement with the linearized continuum theory. Finally, we give an argument why this correlator represents the propagation of a pure gauge, consistently with the absence of physical degrees of freedom in 3d general relativity.Comment: 20 pages, 6 figure

Lead Optimization of 7-benzyloxy 2-(4′-pyridylmethyl)Thio Isoflavone Aromatase Inhibitors

Aromatase, the enzyme responsible for estrogen biosynthesis, is a particularly attractive target in the treatment of hormone-dependent breast cancer. The synthesis and biological evaluation of a series of 2-(4′-pyridylmethyl)thio, 7-alkyl- or aryl-substituted isoflavones as potential aromatase inhibitors are described. The isoflavone derivatives demonstrate IC50 values from 79 to 553 nM and compete with the endogenous substrate, androstenedione. Data supporting the ability of these analogs to suppress aromatase enzyme activity in the SK-BR-3 breast cancer cell line are also presented

Reflections on a degree initiative: the UK's Birmingham Royal Ballet dancers enter the University of Birmingham

This paper provides an opportunity to share experiences and perceptions of the first 5 years of a degree programme for professional dancers. A partnership developed in the mid-1990s between the UK's Birmingham Royal Ballet and the University of Birmingham, Westhill (now School of Education), to provide a part-time, post-experience, flexible study programme for full-time Company dancers. This is the first 'company customised' higher education programme to dovetail studies around rehearsal, performance and touring schedules. Methodology is based on a narrative by the author, informed by ongoing internal and external evaluations, in-depth interviews with dancers and Company managers, documentation and secondary sources. Outcomes indicate that the programme has made a positive difference to the Company, to the dancers and to the wider education and dance/arts world

Identifying spring barley cultivars with differential response to tillage

Cultivars and some cultivar mixtures of spring barley were grown under inversion and non-inversion tillage conditions for three or four years and assessed for disease and yield in order to obtain genotypes that can be used to determine the mechanisms of cultivation adaptation. In general, the higher-yielding cultivars under inversion tillage conditions gave lower yields under non-inversion tillage, whereas low-yielding older cultivars showed relatively smaller reductions in yield under non-inversion tillage. A few cultivars showed preferential yield performance for either inversion or non-inversion tillage and this was irrespective of their overall yield performance. There was no pedigree or breeding programme link between these cultivars and no above-ground gross morphological trait observed was associated with tillage adaptation. Root hairs may contribute to inversion tillage adaptation as a root hair absence mutant was associated with non-inversion adaptation and it is likely that other root-associated traits are responsible also for tillage adaptation. There was no overall cultivar or tillage interaction with rhynchosporium symptoms but a differential tillage interaction may occur in individual years. We have identified clearly contrasting cultivars and tested their across-season robustness with respect to tillage treatment for further detailed mechanistic studies and identification of tillage adaptation traits

Virus-induced translational arrest through 4EBP1/2-dependent decay of 5'-TOP mRNAs restricts viral infection

The mosquito-transmitted bunyavirus, Rift Valley fever virus (RVFV), is a highly successful pathogen for which there are no vaccines or therapeutics. Translational arrest is a common antiviral strategy used by hosts. In response, RVFV inhibits two well-known antiviral pathways that attenuate translation during infection, PKR and type I IFN signaling. Despite this, translational arrest occurs during RVFV infection by unknown mechanisms. Here, we find that RVFV infection triggers the decay of core translation machinery mRNAs that possess a 5'-terminal oligopyrimidine (5'-TOP) motif in their 5'-UTR, including mRNAs encoding ribosomal proteins, which leads to a decrease in overall ribosomal protein levels. We find that the RNA decapping enzyme NUDT16 selectively degrades 5'-TOP mRNAs during RVFV infection and this decay is triggered in response to mTOR attenuation via the translational repressor 4EBP1/2 axis. Translational arrest of 5'-TOPs via 4EBP1/2 restricts RVFV replication, and this increased RNA decay results in the loss of visible RNA granules, including P bodies and stress granules. Because RVFV cap-snatches in RNA granules, the increased level of 5'-TOP mRNAs in this compartment leads to snatching of these targets, which are translationally suppressed during infection. Therefore, translation of RVFV mRNAs is compromised by multiple mechanisms during infection. Together, these data present a previously unknown mechanism for translational shutdown in response to viral infection and identify mTOR attenuation as a potential therapeutic avenue against bunyaviral infection