Adaptive analysis of thermal comfort in university classrooms: correlation between experimental data and mathematical models

Numerous studies are in progress to support adaptive models and to establish quantitative indexes to allow the subject to optimize his comfort conditions. With the aim of finding possible correlations between experimental data and experimental surveys for moderate environments, such as university classrooms, a multiple response questionnaire was elaborated, comprehensive of information for the static and adaptive model proposed by UNI-EN-ISO 10551. The questionnaire was applied in autumn, winter and spring in classrooms of the University of Perugia, Pavia and Terni. During the campaign, all data needed to calculate both Fanger and Wray comfort indices were acquired by instrumental surveys and questionnaire compilation. By means of results analysis the following couple of parameters were correlated: Predicted Mean Vote (PMV) versus the difference between the Equivalent Uniform Temperature and the Comfort Uniform Temperature (Teu - Tu) and the Predicted Percentage of Dissatisfied (PPD) versus the absolute value of the same difference between temperatures (|Teu - Tu|). For the first couple of parameters a linear correlation was found while for the second one a second degree polynomial relation was obtained. Finally values of Operative Temperature T0 and Equivalent Uniform Temperature Teu, obtained for each single experimental survey were compared, observing a very good agreement between the two quantities, with differences that exceed 0.1 K only for a few number of values

WMAP 3yr data with the CCA: anomalous emission and impact of component separation on the CMB power spectrum

The Correlated Component Analysis (CCA) allows us to estimate how the different diffuse emissions mix in CMB experiments, exploiting also complementary information from other surveys. It is especially useful to deal with possible additional components. An application of CCA to WMAP maps assuming that only the canonical Galactic emissions are present, highlights the widespread presence of a spectrally flat "synchrotron" component, largely uncorrelated with the synchrotron template, suggesting that an additional foreground is indeed required. We have tested various spectral shapes for such component, namely a power law as expected if it is flat synchrotron, and two spectral shapes that may fit the spinning dust emission: a parabola in the logS - log(frequency) plane, and a grey body. Quality tests applied to the reconstructed CMB maps clearly disfavour two of the models. The CMB power spectra, estimated from CMB maps reconstructed exploiting the three surviving foreground models, are generally consistent with the WMAP ones, although at least one of them gives a significantly higher quadrupole moment than found by the WMAP team. Taking foreground modeling uncertainties into account, we find that the mean quadrupole amplitude for the three "good" models is less than 1 sigma below the expectation from the standard LambdaCDM model. Also the other reported deviations from model predictions are found not to be statistically significant, except for the excess power at l~40. We confirm the evidence for a marked North-South asymmetry in the large scale (l < 20) CMB anisotropies. We also present a first, albeit preliminary, all-sky map of the "anomalous" component.Comment: 14 pages, 17 figures, submitted to MNRAS, references adde

Embodied Precision : Intranasal Oxytocin Modulates Multisensory Integration

© 2018 Massachusetts Institute of Technology.Multisensory integration processes are fundamental to our sense of self as embodied beings. Bodily illusions, such as the rubber hand illusion (RHI) and the size-weight illusion (SWI), allow us to investigate how the brain resolves conflicting multisensory evidence during perceptual inference in relation to different facets of body representation. In the RHI, synchronous tactile stimulation of a participant's hidden hand and a visible rubber hand creates illusory body ownership; in the SWI, the perceived size of the body can modulate the estimated weight of external objects. According to Bayesian models, such illusions arise as an attempt to explain the causes of multisensory perception and may reflect the attenuation of somatosensory precision, which is required to resolve perceptual hypotheses about conflicting multisensory input. Recent hypotheses propose that the precision of sensorimotor representations is determined by modulators of synaptic gain, like dopamine, acetylcholine, and oxytocin. However, these neuromodulatory hypotheses have not been tested in the context of embodied multisensory integration. The present, double-blind, placebo-controlled, crossover study ( N = 41 healthy volunteers) aimed to investigate the effect of intranasal oxytocin (IN-OT) on multisensory integration processes, tested by means of the RHI and the SWI. Results showed that IN-OT enhanced the subjective feeling of ownership in the RHI, only when synchronous tactile stimulation was involved. Furthermore, IN-OT increased an embodied version of the SWI (quantified as estimation error during a weight estimation task). These findings suggest that oxytocin might modulate processes of visuotactile multisensory integration by increasing the precision of top-down signals against bottom-up sensory input.Peer reviewedFinal Accepted Versio

Acting without being in control: Exploring volition in Parkinson's disease with impulsive compulsive behaviours.

BACKGROUND: Several aspects of volitional control of action may be relevant in the pathophysiology of impulsive-compulsive behaviours (ICB) in Parkinson's disease (PD). We aimed to explore multiple aspects of action control, assessing reward-related behaviour, inhibition (externally and internally triggered) and sense of agency in PD patients, with and without ICB compared to healthy subjects. METHODS: Nineteen PD patients with ICB (PD-ICB), 19 PD without ICB (PD-no-ICB) and 19 healthy controls (HC) underwent a battery of tests including: Intentional Binding task which measures sense of agency; Stop Signal Reaction Time (SSRT) measuring capacity for reactive inhibition; the Marble task, assessing intentional inhibition; Balloon Analog Risk Task for reward sensitivity. RESULTS: One-way ANOVA showed significant main effect of group for action binding (p = 0.004, F = 6.27). Post hoc analysis revealed that PD-ICB had significantly stronger action binding than HC (p = 0.004), and PD-no-ICB (p = 0.04). There was no difference between PD-no-ICB and HC. SSRT did not differ between PD groups, whereas a significant difference between PD-no-ICB and HC was detected (p = 0.01). No other differences were found among groups in the other tasks. CONCLUSIONS: PD patients with ICB have abnormal performance on a psychophysical task assessing sense of agency, which might be related to a deficit in action representation at cognitive/experiential level. Yet, they have no deficit on tasks evaluating externally and internally triggered inhibitory control, or in reward-based decision-making. We conclude that impaired sense of agency may be a factor contributing to ICB in PD patients

Disinvestment in healthcare: An overview of HTA agencies and organizations activities at European level

Background: In an era of a growing economic pressure for all health systems, the interest for "disinvestment" in healthcare increased. In this context, evidence based approaches such as Health Technology Assessment (HTA) are needed both to invest and to disinvest in health technologies. In order to investigate the extent of application of HTA in this field, methodological projects/frameworks, case studies, dissemination initiatives on disinvestment released by HTA agencies and organizations located in Europe were searched. Methods: In July 2015, the websites of HTA agencies and organizations belonging to the European network for HTA (EUnetHTA) and the International Network of Agencies for HTA (INAHTA) were accessed and searched through the use of the term "disinvestment". Retrieved deliverables were considered eligible if they reported methodological projects/frameworks, case studies and dissemination initiatives focused on disinvestment in healthcare. Results: 62 HTA agencies/organizations were accessed and eight methodological projects/frameworks, one case study and one dissemination initiative were found starting from 2007. With respect to methodological projects/frameworks, two were delivered in Austria, one in Italy, two in Spain and three in U.K. As for the case study and the dissemination initiative, both came from U.K. The majority of deliverables were aimed at making an overview of existing disinvestment approaches and at identifying challenges in their introduction. Conclusions: Today, in a healthcare context characterized by resource scarcity and increasing service demand, "disinvestment" from low-value services and reinvestment in high-value ones is a key strategy that may be supported by HTA. The lack of evaluation of technologies in use, in particular at the end of their lifecycle, may be due to the scant availability of frameworks and guidelines for identification and assessment of obsolete technologies that was shown by our work. Although several projects were carried out in different countries, most remain constrained to the field of research. Disinvestment is a relatively new concept in HTA that could pose challenges also from a methodological point of view. To tackle these challenges, it is necessary to construct experiences at international level with the aim to develop new methodological approaches to produce and grow evidence on disinvestment policies and practices

\eta - \eta' Mixing -- From Electromagnetic Transitions to Weak Decays of Charm and Beauty Hadrons (presented at Hadron 2011)

It has been realized for a long time that knowing the \eta and \eta' wave functions in terms of quark and gluon components probes our understanding of non-perturbative QCD dynamics. Great effort has been given to this challenge -- yet no clear picture has emerged even with the most recent KLOE data. We point out which measurements would be most helpful in arriving at a more definite conclusion. A better knowledge of these wave functions will significantly help to disentangle the weight of different decay subprocesses in semi-leptonic decays of D^+, D_s^+ and B^+ mesons. The resulting insights will be instrumental in treating even non-leptonic B transitions involving $\eta$ and $\eta^{\prime}$ and their CP asymmetries; thus they can sharpen the case for or against New Physics intervening there.Comment: Prepared for HADRON 201

Correlated Component Analysis for diffuse component separation with error estimation on simulated Planck polarization data

We present a data analysis pipeline for CMB polarization experiments, running from multi-frequency maps to the power spectra. We focus mainly on component separation and, for the first time, we work out the covariance matrix accounting for errors associated to the separation itself. This allows us to propagate such errors and evaluate their contributions to the uncertainties on the final products.The pipeline is optimized for intermediate and small scales, but could be easily extended to lower multipoles. We exploit realistic simulations of the sky, tailored for the Planck mission. The component separation is achieved by exploiting the Correlated Component Analysis in the harmonic domain, that we demonstrate to be superior to the real-space application (Bonaldi et al. 2006). We present two techniques to estimate the uncertainties on the spectral parameters of the separated components. The component separation errors are then propagated by means of Monte Carlo simulations to obtain the corresponding contributions to uncertainties on the component maps and on the CMB power spectra. For the Planck polarization case they are found to be subdominant compared to noise.Comment: 17 pages, accepted in MNRA

Sign-changing tower of bubbles for a sinh-Poisson equation with asymmetric exponents

Motivated by the statistical mechanics description of stationary 2D-turbulence, for a sinh-Poisson type equation with asymmetric nonlinearity, we construct a concentrating solution sequence in the form of a tower of singular Liouville bubbles, each of which has a different degeneracy exponent. The asymmetry parameter $\gamma\in(0,1]$ corresponds to the ratio between the intensity of the negatively rotating vortices and the intensity of the positively rotating vortices. Our solutions correspond to a superposition of highly concentrated vortex configurations of alternating orientation; they extend in a nontrivial way some known results for $\gamma=1$. Thus, by analyzing the case $\gamma\neq1$ we emphasize specific properties of the physically relevant parameter $\gamma$ in the vortex concentration phenomena

Transparency, Openness and Knowledge Sharing for Rebuilding and Strengthening Government Institutions

The developing of the Open Government Model is allowing an organizational revolution for public administrations, providing to citizens and entrepreneurs a better access to information and public services. It also can allow the increasing of transparency in public agencies and citizen participation, indirectly enhancing collaboration and facilitating democratic processes. Transparency and open data can be powerful tools to stimulate and support public services’ improvements, faster innovation and empower citizens’ rights. So actually many governmental organizations are reviewing and rearranging their processes, information and data to improve policies, enhance legitimacy and openness toward outside parties and citizens. An “open” public knowledge may contribute to establish a collaboration and participation culture among the main stakeholders. In this paper authors focus on a new organizational model to deliver transparent services and to improve an effective collaboration between the public administrations. The research methodology adopted is based on a theoreticaldeductive approach. The study describes general principles to come, through the case strategy, to the empirical analysis of an innovative national government portal called “Transparency Compass Portal”. It tries also to identify the distinctive aspects of some administrative services offered by several public organizations

Memristive devices based on single ZnO nanowires-from material synthesis to neuromorphic functionalities

Memristive and resistive switching devices are considered promising building blocks for the realization of artificial neural networks and neuromorphic systems. Besides conventional top-down memristive devices based on thin films, resistive switching devices based on nanowires (NWs) have attracted great attention, not only for the possibility of going beyond current scaling limitations of the top-down approach, but also as model systems for the localization and investigation of the physical mechanism of switching. This work reports on the fabrication of memristive devices based on ZnO NWs, from NW synthesis to single NW-based memristive cell fabrication and characterization. The bottom-up synthesis of ZnO NWs was performed by low-pressure chemical vapor deposition according to a self-seeding vapor-solid (VS) mechanism on a Pt substrate over large scale (∼cm2), without the requirement of previous seed deposition. The grown ZnO NWs are single crystalline with wurtzite crystal structure and are vertically aligned respect to the growth substrate. Single NWs were then contacted by means of asymmetric contacts, with an electrochemically active and an electrochemically inert electrode, to form NW-based electrochemical metallization memory cells that show reproducible resistive switching behaviour and neuromorphic functionalities including short-term synaptic plasticity and paired pulse facilitation. Besides representing building blocks for NW-based memristive and neuromorphic systems, these single crystalline devices can be exploited as model systems to study physicochemical processing underlaying memristive functionalities thanks to the high localization of switching events on the ZnO crystalline surface