22. Current status of systematic radiopharmaceuticals for the treatment of painful metastatic bonr disease

Intractable bone pain secondary to bone metastasis from prostate or breast cancer, or other malignancies is a major problem in the management of the oncological patient. Treatment often includes the use of analgesic drug therapy; however, radiation therapy, hormonal therapy, chemotherapy, and surgery may also be needed. Advances in systemic radionuclide therapy have increased the number of treatment options available for patients with painful osseous metastases. This treatment modality offers three major advantages i.) by addressing all sites of involvement; and ii) by limiting irradiation of normal tissues due to selective absorption into bone which results in an improved therapeutic ratio. Patients with a positive bone scan are eligible for treatment, and indications and contraindications for use are well defined. Large, prospectively randomized clinical trials have established the efficacy of samarium-153 EDTMP and strontium-89 Cl as a first-line therapy. When these agents are used, pain relief often occurs rapidly and lasts several weeks to months with responses seen in 60–80% of patients, depending on the extent and stage of the disease. With the introduction of modern bone-seeking radiopharmaceuticals as Sm-153 EDTMP toxicity is rare and restricted to reversible myelosuppression. In summary, evidenced based literature suggests that these radiopharmaceuticals can significantly reduce pain and analgesic requirements, improve quality of life, reduce lifetime radiotherapy requirements and management costs, and may even slow the progression of painful metastatic lesions. Retreatment is safe and effective

Teleportation, Braid Group and Temperley--Lieb Algebra

We explore algebraic and topological structures underlying the quantum teleportation phenomena by applying the braid group and Temperley--Lieb algebra. We realize the braid teleportation configuration, teleportation swapping and virtual braid representation in the standard description of the teleportation. We devise diagrammatic rules for quantum circuits involving maximally entangled states and apply them to three sorts of descriptions of the teleportation: the transfer operator, quantum measurements and characteristic equations, and further propose the Temperley--Lieb algebra under local unitary transformations to be a mathematical structure underlying the teleportation. We compare our diagrammatical approach with two known recipes to the quantum information flow: the teleportation topology and strongly compact closed category, in order to explain our diagrammatic rules to be a natural diagrammatic language for the teleportation.Comment: 33 pages, 19 figures, latex. The present article is a short version of the preprint, quant-ph/0601050, which includes details of calculation, more topics such as topological diagrammatical operations and entanglement swapping, and calls the Temperley--Lieb category for the collection of all the Temperley--Lieb algebra with physical operations like local unitary transformation

Cyclooxygenases and the cardiovascular system.

Cyclooxygenase (COX)-1 and COX-2 are centrally important enzymes within the cardiovascular system with a range of diverse, sometimes opposing, functions. Through the production of thromboxane, COX in platelets is a pro-thrombotic enzyme. By contrast, through the production of prostacyclin, COX in endothelial cells is antithrombotic and in the kidney regulates renal function and blood pressure. Drug inhibition of COX within the cardiovascular system is important for both therapeutic intervention with low dose aspirin and for the manifestation of side effects caused by nonsteroidal anti-inflammatory drugs. This review focuses on the role that COX enzymes and drugs that act on COX pathways have within the cardiovascular system and provides an in-depth resource covering COX biology and pharmacology. The review goes on to consider the role of COX in both discrete cardiovascular locations and in associated organs that contribute to cardiovascular health. We discuss the importance of, and strategies to manipulate the thromboxane: prostacyclin balance. Finally within this review the authors discuss testable COX-2-hypotheses intended to stimulate debate and facilitate future research and therapeutic opportunities within the field

Pathogenetic relevance of HLA class II expressing thyroid follicular cells in nontoxic Goiter and in Graves' disease.

HLA class II expressing thyroid follicular cells are found not only in classical thyroid autoimmune diseases, such as Graves' disease, but also in presumably nonautoimmune thyroid disorders such as nontoxic goiter. In this study the immunostimulatory function of the HLA class II expressing thyroid follicular cells derived from patients with nontoxic goiter and with Graves' disease was compared by assessing their capacity to stimulate allogeneic and autologous peripheral blood mononuclear cells, as well as cultured intrathyriodal T lymphocytes. Proliferation of allogeneic peripheral blood mononuclear cells was stimulated by thyroid follicular cells from both nontoxic goiter and Graves' disease thyroids, thus demonstrating that thyroid follicular cells from both disorders are capable of presenting alloantigens. In contrast the proliferation of autologous peripheral blood mononuclear cells was more efficiently stimulated by thyroid follicular cells from Graves' disease than from nontoxic goiter. Cultured intrathyroidal T lymphocytes proliferated specifically in response to autologous HLA class II+ thyroid follicular cells in Graves' disease, but not in nontoxic goiter. The responses were dose dependent and HLA class II restricted. Thyroid autoantigen presentation by HLA class II expressing thyroid follicular cells thus only occurs in Graves' disease, suggesting that HLA class II expression on thyroid follicular cells is an essential feature, but by itself not sufficient for the induction of autoimmunity. Additional factors, the possible nature of which is discussed must also be involved