634 research outputs found
Stylization levels of industrial design objects
The urgency of the research of form making problem in design is associated with the necessity of new understanding of visual culture and new approaches to design engineering representing the integration of artistic and designed problems. The aim of this research is to study the levels of stylization of design objects and dependance (relation) on the specific project objectives and existing technologies. On the ground of quantitative evaluation, the stylization measures are emphasized: figurative image, stylized image and abstract image. Theoretic conclusions are complemented by practical problem solution over creating openwork metal lantern. Variants of both the traditional mains supply of the lantern and the autonomic supply system based on solar energy were offered. The role of semantic factor, affecting the depth of perception of design objects semantic space, is represented in this paper
Microstructured optical fibres for gas sensing: design fabrication and post-fab processing
Air/silica Microstructured Optical Fibers (MOFs) offer new prospects for fiber based sensor devices. In this paper, two topics of particular significance for gas sensing using air guiding Photonic Bandgap Fibers (PBGFs) are discussed. First, we address the issue of controlling the modal properties of PBGFs and demonstrate a single mode, polarization maintaining air guiding PBGF. Secondly, we present recent improvements of a femtosecond laser machining technique for fabricating fluidic channels in PBGFs, which allowed us to achieve cells with multiple side access channels and low additional loss
Model testing of radioactive contamination Cs-137 of soils and bottom sediments in the Romachka river (Tomsk region, Russia)
This paper presents results of testing models for the radioactive contamination of river water and bottom sediments by 137Cs. The scenario for the model testing is based on data from the Romashka River, which was contaminated as a result of accidents at the Siberian Chemical Combine (Russia, Region of Tomsk). The input data include the following: estimates of inventories of 137Cs in the floodplain of the downstream part of Romashka River; the estimated annual runoff of 137Cs from the downstream part of Romachka River; data on the precipitation, hydrological and hydrochemical characteristics of the river. The endpoints of the scenario are model predictions of the activity concentrations of 137Cs in water and bottom sediments along the Romachka River in 2012-2013. Calculations for the Romashka scenario were performed by the Institute of radioprotection and nuclear safety (model CASTEAUR and HAMSTER. As a whole, the radionuclide predictions for137Cs for all considered models. At the same time the CASTEAUR model estimate the activity concentrations of 137Cs and in water more precisely than in bottom sediments
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Conservation of DNA-binding specificity and oligomerisation properties within the p53 family
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.Abstract Background Transcription factors activate their target genes by binding to specific response elements. Many transcription factor families evolved from a common ancestor by gene duplication and subsequent divergent evolution. Members of the p53 family, which play key roles in cell-cycle control and development, share conserved DNA binding and oligomerisation domains but exhibit distinct functions. In this study, the molecular basis of the functional divergence of related transcription factors was investigated. Results We characterised the DNA-binding specificity and oligomerisation properties of human p53, p63 and p73, as well as p53 from other organisms using novel biophysical approaches. All p53 family members bound DNA cooperatively as tetramers with high affinity. Despite structural differences in the oligomerisation domain, the dissociation constants of the tetramers was in the low nanomolar range for all family members, indicating that the strength of tetramerisation was evolutionarily conserved. However, small differences in the oligomerisation properties were observed, which may play a regulatory role. Intriguingly, the DNA-binding specificity of p53 family members was highly conserved even for evolutionarily distant species. Additionally, DNA recognition was only weakly affected by CpG methylation. Prediction of p53/p63/p73 binding sites in the genome showed almost complete overlap between the different homologs. Conclusion Diversity of biological function of p53 family members is not reflected in differences in sequence-specific DNA binding. Hence, additional specificity factors must exist, which allowed the acquisition of novel functions during evolution while preserving original roles.Published versio
The influence of surface finishing methods on touch-sensitive reactions
This paper describes the modern technological development trends in jewelry design. In the jewelry industry, new trends, associated with the introduction of updated non-traditional materials and finishing techniques, are appearing. The existing information-oriented society enhances the visual aesthetics of new jewelry forms, decoration techniques (depth and surface), synthesis of different materials, which, all in all, reveal a bias towards positive effects of visual design. Today, the jewelry industry includes not only traditional techniques, but also such improved techniques as computer-assisted design, 3D-prototyping and other alternatives to produce an updated level of jewelry material processing. The authors present the specific features of ornamental pattern designing, decoration types (depth and surface) and comparative analysis of different approaches in surface finishing. Identifying the appearance or the effect of jewelry is based on proposed evaluation criteria, providing an advanced visual aesthetics basis is predicated on touch-sensitive responses
Anisotropic low field behavior and the observation of flux jumps in CeCoIn5
The magnetic behavior of the heavy fermion superconductor CeCoIn5 has been
investigated. The low field magnetization data show flux jumps in the mixed
state of the superconducting phase in a restricted range of temperature. These
flux jumps begin to disappear below 1.7 K, and are completely absent at 1.5 K.
The magnetization loops are asymmetric, suggesting that surface and geometrical
factors dominate the pinning in this system. The lower critical field (Hc1),
obtained from the magnetization data, shows a linear temperature dependence and
is anisotropic. The calculated penetration depth is also anisotropic, which is
consistent with the observation of an anisotropic superconducting gap in
CeCoIn5. The critical currents, determined from the high field isothermal
magnetization loops, are comparatively low (around 4000 A/cm2 at 1.6 K and 5
kOe).Comment: 4 pages 3 figure
Optical-Model Description of Time-Reversal Violation
A time-reversal-violating spin-correlation coefficient in the total cross
section for polarized neutrons incident on a tensor rank-2 polarized target is
calculated by assuming a time-reversal-noninvariant, parity-conserving
``five-fold" interaction in the neutron-nucleus optical potential. Results are
presented for the system for neutron incident energies
covering the range 1--20 MeV. From existing experimental bounds, a strength of
keV is deduced for the real and imaginary parts of the five-fold
term, which implies an upper bound of order on the relative -odd
strength when compared to the central real optical potential.Comment: 11 pages (Revtex
Studies of Excited States in 208-Pb by Inelastic Proton Scattering at 100 MeV
This work was supported by the National Science Foundation Grant NSF PHY 78-22774 A02 & A03 and by Indiana Universit
Studies of Excited States in 208-Pb by Inelastic Proton Scattering at 135 and 100 MeV
Supported by the National Science Foundation and Indiana Universit
Measurement of the Remaining In-Plane Polarization Transfer Coefficients for the 10-B(p,p') 10-B Reaction at 200 MeV
This research was sponsored by the National Science Foundation Grant NSF PHY-931478
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