837 research outputs found
Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA), updates in 2022-2023. Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease:Opportunities for therapy
This editorial summarizes advances from the Clearance of Interstitial Fluid and Cerebrospinal Fluid (CLIC) group, within the Vascular Professional Interest Area (PIA) of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART). The overarching objectives of the CLIC group are to: (1) understand the age-related physiology changes that underlie impaired clearance of interstitial fluid (ISF) and cerebrospinal fluid (CSF) (CLIC); (2) understand the cellular and molecular mechanisms underlying intramural periarterial drainage (IPAD) in the brain; (3) establish novel diagnostic tests for Alzheimer's disease (AD), cerebral amyloid angiopathy (CAA), retinal amyloid vasculopathy, amyloid-related imaging abnormalities (ARIA) of spontaneous and iatrogenic CAA-related inflammation (CAA-ri), and vasomotion; and (4) establish novel therapies that facilitate IPAD to eliminate amyloid β (Aβ) from the aging brain and retina, to prevent or reduce AD and CAA pathology and ARIA side events associated with AD immunotherapy
Measurement of the mass difference and the binding energy of the hypertriton and antihypertriton
According to the CPT theorem, which states that the combined operation of
charge conjugation, parity transformation and time reversal must be conserved,
particles and their antiparticles should have the same mass and lifetime but
opposite charge and magnetic moment. Here, we test CPT symmetry in a nucleus
containing a strange quark, more specifically in the hypertriton. This
hypernucleus is the lightest one yet discovered and consists of a proton, a
neutron, and a hyperon. With data recorded by the STAR
detector{\cite{TPC,HFT,TOF}} at the Relativistic Heavy Ion Collider, we measure
the hyperon binding energy for the hypertriton, and
find that it differs from the widely used value{\cite{B_1973}} and from
predictions{\cite{2019_weak, 1995_weak, 2002_weak, 2014_weak}}, where the
hypertriton is treated as a weakly bound system. Our results place stringent
constraints on the hyperon-nucleon interaction{\cite{Hammer2002,
STAR-antiH3L}}, and have implications for understanding neutron star interiors,
where strange matter may be present{\cite{Chatterjee2016}}. A precise
comparison of the masses of the hypertriton and the antihypertriton allows us
to test CPT symmetry in a nucleus with strangeness for the first time, and we
observe no deviation from the expected exact symmetry
- …