A prospective randomized study to assess the efficacy of rate and site of atrial pacing on long-term development of atrial fibrillation

Septal Pacing and Atrial Fibrillation Suppression. The Septal Pacing for Atrial Fibrillation Suppression Evaluation (SAFE) study is a single-blinded, parallel randomized designed multicenter study in pacemaker indicated patients with paroxysmal atrial fibrillation (AF). The objective is to evaluate whether the site of atrial pacing - conventional right atrial appendage versus low atrial septal - with or without atrial overdrive pacing will influence the development of persistent AF. The study will provide a definitive answer to whether a different atrial pacing site or the use of AF suppression pacing or both can give incremental antiarrhythmic benefit when one is implanting a device for a patient with a history of paroxysmal AF. (J Cardiovasc Electrophysiol, Vol. 20, pp. 1020-1025) © 2009 Wiley Periodicals, Inc.link_to_subscribed_fulltex