A genetic algorithm-assisted semi-adaptive MMSE multi-user detection for MC-CDMA mobile communication systems

In this work, a novel Minimum-Mean Squared-Error (MMSE) multi-user detector is proposed for MC-CDMA transmission systems working over mobile radio channels characterized by time-varying multipath fading. The proposed MUD algorithm is based on a Genetic Algorithm (GA)-assisted per-carrier MMSE criterion. The GA block works in two successive steps: a training-aided step aimed at computing the optimal receiver weights using a very short training sequence, and a decision-directed step aimed at dynamically updating the weights vector during a channel coherence period. Numerical results evidenced BER performances almost coincident with ones yielded by ideal MMSE-MUD based on the perfect knowledge of channel impulse response. The proposed GA-assisted MMSE-MUD clearly outperforms state-of-the-art adaptive MMSE receivers based on deterministic gradient algorithms, especially for high number of transmitting users

Orbital Evolution of Equal-mass Eccentric Binaries due to a Gas Disk: Eccentric Inspirals and Circular Outspirals

We solve the equations of two-dimensional hydrodynamics describing a circumbinary disk accreting onto an eccentric, equal-mass binary. We compute the time rate of change of the binary semimajor axis $a$ and eccentricity $e$ over a continuous range of eccentricities spanning $e=0$ to $e=0.9$. We find that binaries with initial eccentricities $e_0 \lesssim 0.1$ tend to $e=0$, where the binary semimajor axis expands. All others are attracted to $e \approx 0.4$, where the binary semimajor axis decays. The $e \approx 0.4$ attractor is caused by a rapid change in the disk response from a nearly origin-symmetric state to a precessing asymmetric state. The state change causes the time rates of change $\dot{a}$ and $\dot{e}$ to steeply change sign at the same critical eccentricity resulting in an attracting solution where $\dot{a} = \dot{e} = 0$. This does not, however, result in a stalled, eccentric binary. The finite-transition time between disk states causes the binary eccentricity to evolve beyond the attracting eccentricity in both directions resulting in oscillating orbital parameters and a drift of the semimajor axis. For the chosen disk parameters, binaries with $e_0 \gtrsim 0.1$ evolve toward and then oscillate around $e \approx 0.4$ where they shrink in semimajor axis. Because unequal mass binaries grow toward equal mass through preferential accretion, our results are applicable to a wide range of initial binary mass ratios. Hence, these findings merit further investigations of this disk transition; understanding its dependence on disk parameters is vital for determining the fate of binaries undergoing orbital evolution with a circumbinary disk.Comment: Published in The Astrophysical Journal Letter

Fast Methods for Computing Photometric Variability of Eccentric Binaries: Boosting, Lensing, and Variable Accretion

We analyze accretion-rate time series for equal-mass binaries in co-planar gaseous disks spanning a continuous range of orbital eccentricities up to 0.8, for both prograde and retrograde systems. The dominant variability timescales match that of previous investigations; the binary orbital period is dominant for prograde binaries with $e \gtrsim 0.1$, with a 5 times longer "lump" period taking over for $e\lesssim 0.1$. This lump period fades and drops from 5 times to 4.5 times the binary period as $e$ approaches 0.1, where it vanishes. For retrograde orbits, the binary orbital period dominates at $e \lesssim 0.55$ and is accompanied by a 2 times longer-timescale periodicity at higher eccentricities. The shape of the accretion-rate time series varies with binary eccentricity. For prograde systems, the orientation of an eccentric disk causes periodic trading of accretion between the binary components in a ratio that we report as a function of binary eccentricity. We present a publicly available tool, binlite, that can rapidly ($\lesssim 0.01$~sec) generate templates for the accretion-rate time series, onto either binary component, for choice of binary eccentricity below 0.8. As an example use-case, we build lightcurve models where the accretion rate through the circumbinary disk and onto each binary component sets contributions to the emitted specific flux. We combine these rest-frame, accretion-variability lightcurves with observer-dependent Doppler boosting and binary self-lensing. This allows a flexible approach to generating lightcurves over a wide range of binary and observer parameter space. We envision binlite as the access point to a living database that will be updated with state-of-the-art hydrodynamical calculations as they advance.Comment: Comments welcom

Binary black hole signatures in polarized light curves

Variable active galactic nuclei showing periodic light curves have been proposed as massive black hole binary (MBHB) candidates. In such scenarios the periodicity can be due to relativistic Doppler-boosting of the emitted light. This hypothesis can be tested through the timing of scattered polarized light. Following the results of polarization studies in type I nuclei and of dynamical studies of MBHBs with circumbinary discs, we assume a coplanar equatorial scattering ring, whose elements contribute differently to the total polarized flux, due to different scattering angles, levels of Doppler boost, and line-of-sight time delays. We find that in the presence of a MBHB, both the degree of polarization and the polarization angle have periodic modulations. The minimum of the polarization degree approximately coincides with the peak of the light curve, regardless of the scattering ring size. The polarization angle oscillates around the semi-minor axis of the projected MBHB orbital ellipse, with a frequency equal either to the binary's orbital frequency (for large scattering screen radii), or twice this value (for smaller scattering structures). These distinctive features can be used to probe the nature of periodic MBHB candidates and to compile catalogs of the most promising sub-pc MBHBs. The identification of such polarization features in gravitational-wave detected MBHBs would enormously increase the amount of physical information about the sources, allowing the measurement of the individual masses of the binary components, and the orientation of the line of nodes on the sky, even for monochromatic gravitational wave signals.Comment: 11 pages, 6 figures, submitted to MNRA

Fisurectomy and anoplasty with botulinum toxin injection in patients with chronic anal posterior fissure with hypertonia: a long-term evaluation

Chronic anal fissure\u2019s (CAF) etiopathogenesis remain unclear. CAF of the posterior commissure (CAPF) are often characterized by internal anal sphincter (IAS) hypertonia. The treatment of this disease aimed to reduce IAS hypertonia. Due to the high rate of anal incontinence after LIS, the employment of sphincter preserving surgical techniques associated to pharmacological sphincterotomy appears more sensible. The aim of our study is to evaluate the long-term results of fissurectomy and anoplasty with V\u2013Y cutaneous flap advancement associated to 30 UI of botulinum toxin injection for CAPF with IAS hypertonia. We enrolled 45 patients undergone to fissurectomy and anoplasty with V\u2013Y cutaneous flap advancement and 30 UI botulinum toxin injection. All patients were followed up for at least 5 years after the surgical procedure, with evaluation of anal continence, recurrence rate and MRP (Maximum resting pressure), MSP (Maximum restricting pressure), USWA (Ultrasound wave activity). All patients healed within 40 days after surgery. We observed 3 \u201cde novo\u201d post-operative anal incontinence cases, temporary and minor; the pre-operative ones have only temporary worsened after surgery. We reported 3 cases of recurrences, within 2 years from surgery, all healed after conservative medical therapy. At 5 year follow-up post-operative manometric findings were similar to those of healthy subjects. At 5 years after the surgical procedure, we achieved good results, and these evidences show that surgical section of the IAS is not at all necessary for the healing process of the CAPF

A stochastic approach to LCA of internal insulation solutions for historic buildings

Internal insulation is a typical renovation solution in historic buildings with valuable facades. However, it entails moisture-related risks, which affect the durability and life-cycle environmental performance. In this context, the EU project RIBuild developed a risk assessment method for both hygrothermal and life-cycle performance of internal insulation, to support decision-making. This paper presents the stochastic Life Cycle Assessment method developed, which couples the LCA model to a Monte-Carlo simulation, providing results expressed by probability distributions. It is applied to five insulation solutions, considering different uncertain input parameters and building heating scenarios. In addition, the influence of data variability and quality on the result is analyzed, by using input data from two sources: distributions derived from a generic Life Cycle Inventory database and "deterministic" data from Environmental Product Declarations. The outcomes highlight remarkable differences between the two datasets that lead to substantial variations on the systems performance ranking at the production stage. Looking at the life-cycle impact, the general trend of the output distributions is quite similar among simulation groups and insulation systems. Hence, while a ranking of the solutions based on a "deterministic" approach provides misleading information, the stochastic approach provides more realistic results in the context of decision-making

Proteomic and ionomic profiling reveals significant alterations of protein expression and calcium homeostasis in cystic fibrosis cells

Cystic fibrosis (CF) is an autosomal recessive disorder associated with mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene and defective chloride transport across the epithelial cell membranes. Abnormal epithelial ion transport is the primary cause of persistent airway infections and chronic inflammation in CF patients. In order to gain further insight into the mechanisms of epithelial dysfunctions linked to CFTR mutations, we performed and integrated proteomic and ionomic analysis of human bronchial epithelial IB3-1 cells and compared them with a CFTR-complemented isogenic cell line (C38). Aside from changes that were consistent with known effects related to CFTR mutations, such as differences in glycolytic and gluconeogenic pathways and unfolded protein responses, differential proteomics highlighted significant alteration of protein expression and, in particular, of the 14-3-3 signalling pathway that is known to be involved in cellular calcium (Ca) homeostasis. Of note, restoring chloride efflux by acting on Ca cellular homeostasis has been shown to be a promising therapeutic intervention for CF. Ionomic analysis showed significant changes in the IB3-1 element profile compared with C38 cells and in particular we observed an increase of intracellular Ca that significantly correlates with intracellular zinc (Zn) levels, suggesting a synergistic role of Ca and Zn influx. This finding is particularly intriguing because Zn has been reported to be effective in CF treatment increasing Ca influx. Taken together, our proteomic and ionomic data reveal that CFTR mutation sets in motion endogenous mechanisms counteracting impaired chloride transport mainly acting on epithelial ion transport and increasing intracellular Ca, suggesting potential links between protein expression and this response