Lateral Variations in Lower Crustal Strength Control the Temporal Evolution of Mountain Ranges: Examples From South-East Tibet

Controversy surrounds the rheology of the continental lithosphere, and how this rheology controls the evolution and behavior of mountain ranges. In this study, we investigate the effect of lateral contrasts in the strength of the lower crust, such as those between cratonic continental interiors and weaker rocks in the adjacent deforming regions, on the evolution of topography. We combine numerical modeling with recently published results from stable-isotope palaeoaltimetry in south-east Tibet. Stable-isotope palaeoaltimetry in this region provides constraints on vertical motions, which are required to distinguish between competing models for lithosphere rheology and deformation. We use numerical modeling to investigate the effect of lateral strength contrasts on the shape and temporal evolution of mountain ranges. In combination with palaeoaltimetry results, our modeling suggests that lateral strength contrasts provide a first-order control on the evolution of topography in south-east Tibet. We find that the evolution of topography in the presence of such strength contrasts leads to laterally varying topographic gradients, and to key features of the GPS- and earthquake-derived strain-rate field, without the need for a low-viscosity, lower-crustal channel. We also find that palaeoaltimetric samples may have been transported laterally for hundreds of kilometers, an effect which should be accounted for in their interpretation. Our results are likely to be applicable to the evolution of mountain ranges in general and provide an explanation for the spatial correlation between cratonic lowland regions and steep mountain range-fronts

Subduction tractions and vertical axis rotations in the Zagros-Makran transition zone, SE Iran: The 2013 May 11 M<inf>w</inf> 6.1 Minab earthquake

The source parameters and slip distribution of the 2013 May 11 Mw 6.1 Minab earthquake are studied using seismology, geodesy and field observations. We observe left-lateral strike-slip motion on a fault striking ENE–WSW; approximately perpendicular to previously studied faults in the Minab–Zendan–Palami fault zone. The fault that ruptured in 2013 is one of a series of ∼E–W striking left-lateral faults visible in the geology and geomorphology. These accommodate a velocity field equivalent to right-lateral shear on ∼N–S striking planes by clockwise rotations about vertical axes. The presence of these faults can reconcile differences in estimates of fault slip rates in the western Makran from GPS and Quaternary dating. The longitudinal range of shear in the western Makran is likely to be controlled by the distance over which the underthrusting Arabian lithosphere deepens in the transition from continent–continent collision in the Zagros to oceanic subduction in the Makran.This work forms part of the NERC- and ESRC-funded project ’EarthquakesWithout Frontiers‘. CP is funded by a NERC PhD studentship.This is the final version of the article. It first appeared from Oxford University Press via http://dx.doi.org/10.1093/gji/ggv20

Assessment of human leukocyte antigen immunogenicity: current methods, challenges and opportunities.

PURPOSE OF REVIEW: Donor-recipient human leukocyte antigen (HLA) matching improves outcomes after solid-organ transplantation, but current assessment of HLA incompatibility is inadequate as it does not consider the relative immunogenicity of individual HLA mismatches. In this article, we review existing strategies for assessing HLA immunogenicity and discuss current challenges and future opportunities in this field. RECENT FINDINGS: Current HLA immunogenicity algorithms focus primarily on the humoral component of the alloimmune response and aim to determine a measure of 'dissimilarity' between donor and recipient HLA. This can be achieved by deriving information from comparison of donor and recipient HLA at the amino acid sequence, structural and/or the physicochemical level, accounting for both B-cell and T-cell pathways of alloreactivity. Substantial evidence now supports the superiority of this molecular definition of HLA incompatibility, over conventional enumeration of HLA antigenic differences, for assessing the risk of humoral alloimmunity and for predicting graft outcomes after transplantation. SUMMARY: Significant progress has been made in developing computational HLA immunogenicity algorithms that offer exciting opportunities for a more rational approach to determining the degree of donor-recipient HLA incompatibility and to defining HLA-related immunological risk. A number of challenges now need to be overcome to enable their implementation into clinical practice

Neutron scattering study of a quasi-2D spin-1/2 dimer system Piperazinium Hexachlorodicuprate under hydrostatic pressure

We report inelastic neutron scattering study of a quasi-two-dimensional S=1/2 dimer system Piperazinium Hexachlorodicuprate under hydrostatic pressure. The spin gap {\Delta} becomes softened with the increase of the hydrostatic pressure up to P= 9.0 kbar. The observed threefold degenerate triplet excitation at P= 6.0 kbar is consistent with the theoretical prediction and the bandwidth of the dispersion relation is unaffected within the experimental uncertainty. At P= 9.0 kbar the spin gap is reduced to 0.55 meV from 1.0 meV at ambient pressure.Comment: 4 pages, 5 figure

A Key and check-list to Kenya Orchids

Volume: XXI