Evolutionary Conservation of the Heterochronic Pathway in C. elegans and C. briggsae

Heterochronic genes control the sequence and timing of developmental events during four larval stages of Caenorhabitis nematodes. Mutations in these genes may cause skipping or reiteration of developmental events. C. briggsae is a close relative of C. elegans. These species have similar morphology and share the same ecological niche. C. briggsae undergoes the same developmental pathway consisting of four larval stages before reaching adulthood. It also has the same set of heterochronic genes. Lin-28 is one of the heterochronic genes that also exists in other animals from flies to humans. It conservatively blocks the maturation of let-7 miRNA, the process is generally associated with the stem cell state. lin-28 is silenced as cells differentiate. C. elegans mutants of lin-28 have a reduced number of seam cells and precocious alae. Despite the highly conserved protein sequence, C. briggsae develop a distinct phenotype when its lin 28 is disrupted. Worms did not have a characteristic vulval development defect, they also became lethargic and had a reduced fertility. This observation led to a question of how conserved the heterochronic pathway is in close species

Genetics of intercellular signalling in C. elegans

Cell-cell interactions play a significant role in controlling cell fate during development of the nematode Caenorhabditis elegans. It has been found that two genes, glp-1 and lin-12, are required for many of these decisions. glp-1 is required for induction of mitotic proliferation in the germline by the somatic distal tip cell and for induction of the anterior pharynx early in embryogenesis. lin-12 is required for the interactions between cells of equivalent developmental potential, which allow them to take on different fates. Comparison of these two genes on a molecular level indicates that they are similar in sequence and organization, suggesting that the mechanisms of these two different sets of cell-cell interactions are similar

Controlling occupational cancers in Australia

Lin Fritschi, Renae C Fernandez, Deborah A Vallance, Terry J Slevin, Alison Reid, Timothy R Driscoll, Deborah C Glas

Lin Lin Lin v. Atty Gen USA

Agenc

Deformable Part-based Fully Convolutional Network for Object Detection

Existing region-based object detectors are limited to regions with fixed box geometry to represent objects, even if those are highly non-rectangular. In this paper we introduce DP-FCN, a deep model for object detection which explicitly adapts to shapes of objects with deformable parts. Without additional annotations, it learns to focus on discriminative elements and to align them, and simultaneously brings more invariance for classification and geometric information to refine localization. DP-FCN is composed of three main modules: a Fully Convolutional Network to efficiently maintain spatial resolution, a deformable part-based RoI pooling layer to optimize positions of parts and build invariance, and a deformation-aware localization module explicitly exploiting displacements of parts to improve accuracy of bounding box regression. We experimentally validate our model and show significant gains. DP-FCN achieves state-of-the-art performances of 83.1% and 80.9% on PASCAL VOC 2007 and 2012 with VOC data only.Comment: Accepted to BMVC 2017 (oral

Ming-Hui Lin, flute and Ayako Yoda, piano and harpsichord, April 25, 2015

This is the concert program of the Ming-Hui Lin, flute and Ayako Yoda, piano and harpsichord performance on Saturday, April 25, 2015 at 8:30 p.m., at the Marshall Room, 855 Commonwealth Avenue. Works performed were Sonata in C major for Flute and Basso Continuo, BWV 1033 by Johann Sebastian Bach, Sonata for Flute and Piano, No. 3 by Philippe Gaubert, Sonatina for Flute and Piano by Eldin Burton, Syrinx for Flute solo by Claude Debussy, and Introduction and Variations on "Trockne Blumen" in E minor for Flute and Piano, D802 by Franz Schubert. Digitization for Boston University Concert Programs was supported by the Boston University Humanities Library Endowed Fund