Determination of electron-nucleus collision geometry with forward neutrons

There are a large number of physics programs one can explore in electron-nucleus collisions at a future electron-ion collider. Collision geometry is very important in these studies, while the measurement for an event-by-event geometric control is rarely discussed in the prior deep inelastic scattering experiments off a nucleus. This paper seeks to provide some detailed studies on the potential of tagging collision geometries through forward neutron multiplicity measurements with a zero degree calorimeter. This type of geometry handle, if achieved, can be extremely beneficial in constraining nuclear effects for the electron-nucleus program at an electron-ion collider

First-principles study of the effects of gold adsorption on the Al(001) surface properties

In this work, we have studied theoretically the effects of gold adsorption on the Al(001) surface, using {\it ab initio} pseudo-potential method in the framework of the density functional theory. Having found the hollow sites at the Al(001) surface as the most preferred adsorption sites, we have investigated the effects of the Au adsorption with different coverages ($\Theta$=0.11, 0.25, 0.50, 0.75, 1.00 ML) on the geometry, adsorption energy, surface dipole moment, and the work-function of the Al(001) surface. The results show that, even though the work-function of the Al substrate increases with the Au coverage, the surface dipole moment decreases with the changes in coverage from $\Theta=0.11$ ML to $\Theta=0.25$ ML. We have explained this behavior by analyzing the electronic and ionic charge distributions. Furthermore, by studying the diffusion of Au atoms in to the substrate, we have shown that at room temperature the diffusion rate of Au atoms in to the substrate is negligible but, increasing the temperature to about 200$^\circ$ C the Au atoms significantly diffuse in to the substrate, in agreement with the experiment.Comment: 19 pages, 9 eps figure

Using Ontology Fingerprints to evaluate genome-wide association study results

We describe an approach to characterize genes or phenotypes via ontology fingerprints which are composed of Gene Ontology (GO) terms overrepresented among those PubMed abstracts linked to the genes or phenotypes. We then quantify the biological relevance between genes and phenotypes by comparing their ontology fingerprints to calculate a similarity score. We validated this approach by correctly identifying genes belong to their biological pathways with high accuracy, and applied this approach to evaluate GWA study by ranking genes associated with the lipid concentrations in plasma as well as to prioritize genes within linkage disequilibrium (LD) block. We found that the genes with highest scores were: ABCA1, LPL, and CETP for HDL; LDLR, APOE and APOB for LDL; and LPL, APOA1 and APOB for triglyceride. In addition, we identified some top ranked genes linking to lipid metabolism from the literature even in cases where such knowledge was not reflected in current annotation of these genes. These results demonstrate that ontology fingerprints can be used effectively to prioritize genes from GWA studies for experimental validation

Probing Gluon Saturation through Dihadron Correlations at an Electron-Ion Collider

Two-particle azimuthal angle correlations have been proposed to be one of the most direct and sensitive probes to access the underlying gluon dynamics involved in hard scatterings. In anticipation of an Electron-Ion Collider (EIC), detailed studies of dihadron correlation measurements in electron-proton and electron-ion collisions at an EIC have been performed. The impact of such measurements on the understanding of the different gluon distribution functions, as a clean signature for gluon saturation and to constrain saturation models further, has been explored. It is shown that dihadron correlation measurements will be one of the key methods to probe gluon saturation phenomena at a future EIC.Comment: 13 pages, 13 eps figure

Alternative treatment using topical tacrolimus for erosive oral lichen planus resistant to steroids

Case reportsLichen planus is a T-cell–mediated immunological disorder causing inflammatory lesions on the skin and oral mucosa. The etiology of lichen planus remains unknown, and the current therapeutic strategy is primarily to manage the symptoms. Although topical steroids are commonly used in the treatment of lichen planus, there are lesions refractory to steroids that require different treatment options. This report is of a patient with bilateral erosive oral lichen planus of the buccal mucosa. The lesions did not respond to highpotency topical steroids, so they were treated with topical tacrolimus 0.1% ointment, a potent topical immunosuppressant. All the erosive lesions healed, and the associated pain and bleeding disappeared after 6 weeks of treatment.published_or_final_versio