2,867 research outputs found
Liposomes mediated drug delivery in infectious diseases
Liposome-mediated drug delivery systems along with other newer approaches of drug targeting have revolutionized the measures of controlling parasitic infections, including, malaria, leishmania, fungal infections, besides providing a new approach to control several bacterial infections, including Mycobacterial, Salmonella, Pseudomonas, etc. some of which have acquired resistance. These approaches provide definite reduction in drug toxicity, specially in leishmaniasis and control of candidiasis and other pathogenic fungi. Liposomal drugs, like amphotericin B, would have extensive use in the management of fungal diseases. Liposome mediated drug delivery has an exceptional advantage of biocompatibility, biodegradability, non-immunogenicity and can be used in clinical cases without any side effects
Possible manifestation of spin fluctuations in the temperature behavior of resistivity in Sm_{1.85}Ce_{0.15}CuO_4 thin films
A pronounced step-like (kink) behavior in the temperature dependence of
resistivity is observed in the optimally-doped
thin films around and attributed to
manifestation of strong spin fluctuations induced by moments with the
energy . In addition to fluctuation
induced contribution due to thermal broadening effects (of the
width ), the experimental data are found to be well fitted
accounting for residual (zero-temperature) , electron-phonon and electron-electron contributions. The
best fits produced , ,
, and for estimates of the plasmon frequency, the
impurity scattering rate, electron-phonon coupling constant, and the Fermi
energy, respectively.Comment: 6 pages (REVTEX4), 2 EPS figures; accepted for publication in JETP
Letter
Of Taxonomies and Taxonomic Theories
This presentation explores the relationship between taxonomies and taxonomic theories and explores various concerns such as the difference between taxonomy to be a taxonomic theory, the need for a taxonomy to be extended in some way for it to be a theory, and etc
Taxonomy Development in Health-IT
Health-IT is attracting increasing attention in the research community. To understand the relevant constructs and the relationships among them, many authors present taxonomies or typologies for classifying different things in health-IT. Even with much attention to health-IT, there is still limited theoretical knowledge in this field. This may be attributed to our observation that the process of developing taxonomies has not been adequately addressed in the health-IT literature. In this paper we address this challenge by (a) a comprehensive literature survey that shows a high diversity in the field and that the related discussion of the structural nature has largely been ad hoc, (b) presenting methods for developing health-IT taxonomies, and, (c) contributing to the theoretical foundations of the field by a taxonomy for health-IT applications
Macrobenthos of intertidal zone of Versova along the coast of Mumbai
To assess the biodiversity of macro benthos in the changing environment along the coast of Mumbai, the intertidal zone of Versova was identified. The water quality in this intertidal region was poor with low pH, salinity and dissolved oxygen, and high nitrite, nitrate, phosphate and ammonia. The substratum was sandy with 1.29% organic matter in it. Mean faunal density of 2257 no./m² was recorded during the study which was mainly contributed by polychaetes (83.5%) followed by amphipods (14.5%), while other groups represented were isopods, crabs, hermit crabs, unidentified decapods, pelecypods and gastropods. Average biomass of 34.83 g/m² (93.7%) was contributed by polychaetes. Shannon and Wiener Index (0.4107) indicated heavy pollution in the intertidal area of Versova
The Friedreich ataxia GAA repeat expansion mutation induces comparable epigenetic changes in human and transgenic mouse brain and heart tissues
Friedreich ataxia (FRDA) is caused by a homozygous GAA repeat expansion mutation
within intron 1 of the FXN gene, leading to reduced expression of frataxin protein.
Evidence suggests that the mutation may induce epigenetic changes and heterochromatin
formation, thereby impeding gene transcription. In particular, studies using FRDA patient
blood and lymphoblastoid cell lines have detected increased DNA methylation of specific
CpG sites upstream of the GAA repeat and histone modifications in regions flanking the
GAA repeat. In this report we show that such epigenetic changes are also present in
FRDA patient brain, cerebellum and heart tissues, the primary affected systems of the
disorder. Bisulfite sequence analysis of the FXN flanking GAA regions reveals a shift in
the FRDA DNA methylation profile, with upstream CpG sites becoming consistently
hypermethylated and downstream CpG sites becoming consistently hypomethylated. We
also identify differential DNA methylation at three specific CpG sites within the FXN
promoter and one CpG site within exon 1. Furthermore, we show by chromatin
immunoprecipitation (ChIP) analysis that there is overall decreased histone H3K9
acetylation together with increased H3K9 methylation of FRDA brain tissue. Further
studies of brain, cerebellum and heart tissues from our GAA repeat expansion-containing
FRDA YAC transgenic mice reveal comparable epigenetic changes to those detected in
FRDA patient tissue. We have thus developed a mouse model that will be a valuable
resource for future therapeutic studies targeting epigenetic modifications of the FXN gene
to increase frataxin expression
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