Novel Approach to the Energy Analysis of Mine Cooling Strategies

The extraction of minerals and coal at increasing depth, employing higher-powered, mechanized machinery to increase production levels imposes an increased burden on the ability to maintain an acceptable mine climate. Any deterioration in the mine climate within working zones may adversely affect the health and safety of the workforce. The combination of the optimal design of the mine system layout, together with the selective application of suitable ventilation and cooling systems, may be used to control the climate within working zones. The adoption of mechanical cooling within mines is an expensive process in terms of both capital and operating costs. Therefore, as mechanized mining takes place at increased depth, the need to maintain or improve the mine climate becomes more expensive. Consequently, to decrease overhead costs, reduce energy consumption and meet current and future environmental obligations, it is essential to provide the mine operator with a method with which to determine the most cost effective and efficient mine cooling system. To perform this analysis it is necessary to have a good understanding of the energy balances governing both the operation and utilization of a cooling system. This paper introduces the application of a novel approach to energy analysis of mine cooling systems, with a combination of the concepts of exergy and composite curves. These methods are used extensively throughout chemical and process industries to increase energy efficiency and reduce capital and operating costs. An outline of the methods employed in the application of these techniques to the energy analysis of a mining cooling system is presented

Phage engineering: how advances in molecular biology and synthetic biology are being utilized to enhance the therapeutic potential of bacteriophages

Background The therapeutic potential of bacteriophages has been debated since their first isolation and characterisation in the early 20th century. However, a lack of consistency in application and observed efficacy during their early use meant that upon the discovery of antibiotic compounds research in the field of phage therapy quickly slowed. The rise of antibiotic resistance in bacteria and improvements in our abilities to modify and manipulate DNA, especially in the context of small viral genomes, has led to a recent resurgence of interest in utilising phage as antimicrobial therapeutics. Results In this article a number of results from the literature that have aimed to address key issues regarding the utility and efficacy of phage as antimicrobial therapeutics utilising molecular biology and synthetic biology approaches will be introduced and discussed, giving a general view of the recent progress in the field. Conclusions Advances in molecular biology and synthetic biology have enabled rapid progress in the field of phage engineering, with this article highlighting a number of promising strategies developed to optimise phages for the treatment of bacterial disease. Whilst many of the same issues that have historically limited the use of phages as therapeutics still exist, these modifications, or combinations thereof, may form a basis upon which future advances can be built. A focus on rigorous in vivo testing and investment in clinical trials for promising candidate phages may be required for the field to truly mature, but there is renewed hope that the potential benefits of phage therapy may finally be realised