Numerical simulation of Quasi-Normal Modes in time-dependent background

We study the massless scalar wave propagation in the time-dependent Schwarzschild black hole background. We find that the Kruskal coordinate is an appropriate framework to investigate the time-dependent spacetime. A time-dependent scattering potential is derived by considering dynamical black hole with parameters changing with time. It is shown that in the quasinormal ringing both the decay time-scale and oscillation are modified in the time-dependent background.Comment: 10 pages, 8 figures; reference adde

Synthesis and Characterization of Azole Isoflavone Inhibitors of Aromatase

The synthesis and biological evaluation of a series of 2-azole and 2-thioazole isoflavones as potential aromatase inhibitors are described. Differences in inhibitory activity of triazole and imidazole inhibitors are rationalized with density functional theory to expose a key difference in the electronic structure of these molecules. In addition, difference binding spectra of inhibitors to immunoaffinity-purified aromatase produces classical Type II spectra consistent with coordination of the nitrogen lone pair electrons to the aromatase P450 heme

Synthesis and Characterization of Azole Isoflavone Inhibitors of Aromatase

The synthesis and biological evaluation of a series of 2-azole and 2-thioazole isoflavones as potential aromatase inhibitors are described. Differences in inhibitory activity of triazole and imidazole inhibitors are rationalized with density functional theory to expose a key difference in the electronic structure of these molecules. In addition, difference binding spectra of inhibitors to immunoaffinity-purified aromatase produces classical Type II spectra consistent with coordination of the nitrogen lone pair electrons to the aromatase P450 heme

Mott-Hubbard Transition of Bosons in Optical Lattices with Three-body Interactions

In this paper, the quantum phase transition between superfluid state and Mott-insulator state is studied based on an extended Bose-Hubbard model with two- and three-body on-site interactions. By employing the mean-field approximation we find the extension of the insulating 'lobes' and the existence of a fixed point in three dimensional phase space. We investigate the link between experimental parameters and theoretical variables. The possibility to obverse our results through some experimental effects in optically trapped Bose-Einstein Condensates(BEC) is also discussed.Comment: 7 pages, 4 figures; to be appear in Phys. Rev.

Thermodynamic Geometry and Critical Behavior of Black Holes

Based on the observations that there exists an analogy between the Reissner-Nordstr\"om-anti-de Sitter (RN-AdS) black holes and the van der Waals-Maxwell liquid-gas system, in which a correspondence of variables is $(\phi, q) \leftrightarrow (V,P)$, we study the Ruppeiner geometry, defined as Hessian matrix of black hole entropy with respect to the internal energy (not the mass) of black hole and electric potential (angular velocity), for the RN, Kerr and RN-AdS black holes. It is found that the geometry is curved and the scalar curvature goes to negative infinity at the Davies' phase transition point for the RN and Kerr black holes. Our result for the RN-AdS black holes is also in good agreement with the one about phase transition and its critical behavior in the literature.Comment: Revtex, 18 pages including 4 figure

Genetic and Environmental Influences on Blood Pressure and Body Mass Index in the National Academy of Sciences-National Research Council World War II Veteran Twin Registry

Blood pressure (BP) and obesity phenotypes may covary due to shared genetic or environmental factors or both. Furthermore, it is possible that the heritability of BP differs according to obesity status-a form of GxE interaction. This hypothesis has never been tested in White twins. The present study included 15 924 White male twin pairs aged between 15 and 33 years from the National Academy of Sciences-National Research Council World War II Veteran Twin Registry. Systolic and diastolic BPs, as well as height and weight, were measured at the induction physical examination. Body mass index (BMI) was used as the index of general obesity. Quantitative genetic modeling was performed using Mx software. Univariate analysis showed that narrow sense heritabilities (95% CI) for systolic BP, diastolic BP, height, and BMI were 0.401 (0.381-0.420), 0.297 (0.280-0.320), 0.866 (0.836-0.897), and 0.639 (0.614-0.664), respectively. Positive phenotypic correlations of BMI with systolic BP (r=0.13) and diastolic BP (r=0.08) were largely due to genetic factors (70% and 86%, respectively). The gene-BMI interaction analysis did not show any support for a modifying effect of BMI on genetic and environmental influences of systolic BP and diastolic BP. Our results suggest that correlations between BP and BMI are mainly explained by common genes influencing both. Higher BMI levels have no influence on the penetrance of genetic vulnerability to elevated BP. These conclusions may prove valuable for gene-finding studies

Lead Optimization of 7-benzyloxy 2-(4′-pyridylmethyl)Thio Isoflavone Aromatase Inhibitors

Aromatase, the enzyme responsible for estrogen biosynthesis, is a particularly attractive target in the treatment of hormone-dependent breast cancer. The synthesis and biological evaluation of a series of 2-(4′-pyridylmethyl)thio, 7-alkyl- or aryl-substituted isoflavones as potential aromatase inhibitors are described. The isoflavone derivatives demonstrate IC50 values from 79 to 553 nM and compete with the endogenous substrate, androstenedione. Data supporting the ability of these analogs to suppress aromatase enzyme activity in the SK-BR-3 breast cancer cell line are also presented

Review of dynamic positioning control in maritime microgrid systems

For many offshore activities, including offshore oil and gas exploration and offshore wind farm construction, it is essential to keep the position and heading of the vessel stable. The dynamic positioning system is a progressive technology, which is extensively used in shipping and other maritime structures. To maintain the vessels or platforms from displacement, its thrusters are used automatically to control and stabilize the position and heading of vessels in sea state disturbances. The theory of dynamic positioning has been studied and developed in terms of control techniques to achieve greater accuracy and reduce ship movement caused by environmental disturbance for more than 30 years. This paper reviews the control strategies and architecture of the DPS in marine vessels. In addition, it suggests possible control principles and makes a comparison between the advantages and disadvantages of existing literature. Some details for future research on DP control challenges are discussed in this paper