15 research outputs found
Initiation of anti-osteoporotic therapy in patients with recent fractures: a nationwide analysis of prescription rates and persistence
Are long-term bisphosphonate users a reality? Dose years for current bisphosphonate users assessed using the danish national prescription database
Anti-osteoporotic therapy in Denmark—predictors and demographics of poor refill compliance and poor persistence
Cessation rate of anti-osteoporosis treatments and risk factors in Spanish primary care settings: a population-based cohort analysis
Initiation of anti-osteoporotic therapy in patients with recent fractures: a nationwide analysis of prescription rates and persistence
Association between refill compliance to oral bisphosphonate treatment, incident fractures, and health care costs—an analysis using national health databases
Anti-osteoporosis medication treatment pattern after osteoporotic fracture during 2010–2016 in Fujian, China
Potential Clinical and Economic Impact of Nonadherence with Osteoporosis Medications.
This study aims to estimate the potential clinical and economic implications of therapeutic adherence to bisphosphonate therapy. A validated Markov microsimulation model was used to estimate the impact of varying adherence to bisphosphonate therapy on outcomes (the number of fractures and the quality-adjusted life-years [QALYs]), health-care costs, and the cost-effectiveness of therapy compared with no treatment. Adherence was divided into persistence and compliance, and multiple scenarios were considered for both concepts. Analyses were performed for women aged 65 years with a bone mineral density T-score of -2.5. Health outcomes and the cost-effectiveness of therapy improved significantly with increasing compliance and/or persistence. In the case of real-world persistence and with a medical possession ratio (MPR; i.e., the number of doses taken divided by the number of doses prescribed) of 100%, the QALY gain and the number of fractures prevented represented only 48 and 42% of the values estimated assuming full persistence, respectively. These proportions fell to 27 and 23% with an MPR value of 80%. The costs per QALY gained, for branded bisphosphonates (and generic alendronate), were estimated at 19,069 (4,871), 32,278 (11,985), and 64,052 (30,181) for MPR values of 100, 80, and 60%, respectively, assuming real-world persistence. These values were 16,997 (2,215), 24,401 (6,179), and 51,750 (20,569), respectively, assuming full persistence. In conclusion, poor compliance and failure to persist with osteoporosis medications results not only in deteriorating health outcomes, but also in a decreased cost-effectiveness of drug therapy. Adherence therefore remains an important challenge for health-care professionals treating osteoporosis