Regulating Retinoic Acid Availability during Development and Regeneration: The Role of the CYP26 Enzymes.

This review focuses on the role of the Cytochrome p450 subfamily 26 (CYP26) retinoic acid (RA) degrading enzymes during development and regeneration. Cyp26 enzymes, along with retinoic acid synthesising enzymes, are absolutely required for RA homeostasis in these processes by regulating availability of RA for receptor binding and signalling. Cyp26 enzymes are necessary to generate RA gradients and to protect specific tissues from RA signalling. Disruption of RA homeostasis leads to a wide variety of embryonic defects affecting many tissues. Here, the function of CYP26 enzymes is discussed in the context of the RA signalling pathway, enzymatic structure and biochemistry, human genetic disease, and function in development and regeneration as elucidated from animal model studies

Regulating Retinoic Acid Availability during Development and Regeneration: The Role of the CYP26 Enzymes.

This review focuses on the role of the Cytochrome p450 subfamily 26 (CYP26) retinoic acid (RA) degrading enzymes during development and regeneration. Cyp26 enzymes, along with retinoic acid synthesising enzymes, are absolutely required for RA homeostasis in these processes by regulating availability of RA for receptor binding and signalling. Cyp26 enzymes are necessary to generate RA gradients and to protect specific tissues from RA signalling. Disruption of RA homeostasis leads to a wide variety of embryonic defects affecting many tissues. Here, the function of CYP26 enzymes is discussed in the context of the RA signalling pathway, enzymatic structure and biochemistry, human genetic disease, and function in development and regeneration as elucidated from animal model studies

Waltz User Manual

This Document describes relevant information to understand and control the Waltz Visualization System. Waltz is a tool to visualize three dimensional data and reads special reference files containing details of the data file, path name, dimensions and aspect ratios of the data. Waltz (as the name suggests) contains three parts: Generalization, Specialization and Abstraction. The Generalization Process splits the data into spatially connected groups. A specialization is formed from a subset (selection) of these groups. The results are displayed in multiple abstract views of the same data. These abstractions are formed by losing or augmenting the data to facilitate in the understanding of the data

Sticky Pixels: Evolutionary Growth by Random Drop Ballistic Aggregation

Over the years many techniques have been developed for simulating and modelling trees, ferns, crystals and natural structures. Indeed, many complex and realistic images have been formed. Often, these rely on rule based systems to create the structure, they start with a simple form and progressively refine it into a more complex form by applying rules. We use the notion of Sticky Pixels to form textures. The pixels (or objects) move around the space, when they touch another object they stick together to form a larger cluster. The objects aggregate and stop at the place and position where they first touched. Such an aggregation generates neighbourhoods of pixels that form natural looking shapes. The pixels may randomly walk around (such as using Brownian motion), or be guided along pre-defined routes (often described as ballistic), to obtain different structures. We use a ballistic aggregation technique, where the particles are randomly dropped onto a canvas, migrate and stick onto the closest position of the nearest cluster. We present Sticky Pixels, explain different parameters and describe our algorithm

An Overview of Rendering from Volume Data --- including Surface and Volume Rendering

Volume rendering is a title often ambiguously used in science. One meaning often quoted is: `to render any three volume dimensional data set'; however, within this categorisation `surface rendering'' is contained. Surface rendering is a technique for visualising a geometric representation of a surface from a three dimensional volume data set. A more correct definition of Volume Rendering would only incorporate the direct visualisation of volumes, without the use of intermediate surface geometry representations. Hence we state: `Volume Rendering is the Direct Visualisation of any three dimensional Volume data set; without the use of an intermediate geometric representation for isosurfaces'; `Surface Rendering is the Visualisation of a surface, from a geometric approximation of an isosurface, within a Volume data set'; where an isosurface is a surface formed from a cross connection of data points, within a volume, of equal value or density. This paper is an overview of both Surface Rendering and Volume Rendering techniques. Surface Rendering mainly consists of contouring lines over data points and triangulations between contours. Volume rendering methods consist of ray casting techniques that allow the ray to be cast from the viewing plane into the object and the transparency, opacity and colour calculated for each cell; the rays are often cast until an opaque object is `hit' or the ray exits the volume

Publishing Time Dependent Oceanographic Visualizations using VRML

Oceanographic simulations generate time dependent data; thus, visualizations of this data should include and realize the variable `time'. Moreover, the oceanographers are located across the world and they wish to conveniently communicate and exchange these temporal realizations. This publication of material may be achieved using different methods and languages. VRML provides one convenient publication medium that allows the visualizations to be easily viewed and exchanged between users. Using VRML as the implementation language, we describe five categories of operation. The strategies are determined by the level of calculation that is achieved at the generation stage compared to the playing of the animation. We name the methods: 2D movie, 3D spatial, 3D flipbook, key frame deformation and visualization program

Waltz - An exploratory visualization tool for volume data, using multiform abstract displays

Although, visualization is now widely used, misinterpretations still occur. There are three primary solutions intended to aid a user interpret data correctly. These are: displaying the data in different forms (Multiform visualization); simplifying (or abstracting) the structure of the viewed information; and linking objects and views together (allowing corresponding objects to be jointly manipulated and interrogated). These well-known visualization techniques, provide an emphasis towards the visualization display. We believe however that current visualization systems do not effectively utilise the display, for example, often placing it at the end of a long visualization process. Our visualization system, based on an adapted visualization model, allows a display method to be used throughout the visualization process, in which the user operates a 'Display (correlate) and Refine' visualization cycle. This display integration provides a useful exploration environment, where objects and Views may be directly manipulated; a set of 'portions of interest' can be selected to generate a specialized dataset. This may subsequently be further displayed, manipulated and filtered