A bootstrap method to investigate the variability of overheating risk against the future climate uncertainty in dwellings

Future overheating risk in dwellings can be potentially mitigated by minimising the variability of overheating hours against uncertainties in future climate via robust optimisation. However, the estimation of this variability value through the utilisation of percentile-based probabilistic weather data has yet to be sufficiently investigated. In this simulation-based study, the bootstrap method is used to quantify the accuracy of the variability estimation via percentilebased weather data. The results indicate significant overheating risk in regulation-compliant houses. An increased degree of difficulty is also suggested in obtaining accurate estimations when considering time periods further in the future and when assuming higher carbon emissions. In addition, the skew normal distribution can be used for a simpler and faster estimation, but the underlying uncertainties must be strengthened throughout its implementation

Retrofit solutions for solid wall dwellings in England: the impact of uncertainty upon the energy performance gap

This study seeks to evaluate the impact of uncertainty in the pre-retrofit thermal performance of solid walls of English dwellings on post-retrofit energy use. Five dwelling archetypes, broadly representative of English solid wall properties, were modelled pre- and post-retrofit, under different wall insulation scenarios, using dynamic thermal simulation. Findings indicate that whilst solid wall insulation could result in a significant reduction of space heating demand, uncertainties in the pre-retrofit solid wall U-value could lead to a gap between the anticipated and actual energy performance. Specifically, results show that if the current U-value assumption of 2.1 W/m2K is indeed an overestimation of the in-situ U-value of solid walls, then the anticipated carbon savings could be significantly reduced by up to 65%. Practical application: The performance gap observed in this study revealed that the actual carbon savings arising from the retrofit of solid wall properties could be significantly lower than predicted. This will not only affect UK Government carbon reduction targets but it can also result in a lack of confidence amongst stakeholders who may consequently doubt the effectiveness of energy retrofit measures, thus reducing their uptake. Uncertainties regarding solid wall U-values may necessitate the re-examination of the carbon targets set for the retrofit of solid wall dwellings and the exploration of alternative ways to further reduce their carbon emissions, e.g. by specifying higher insulation thicknesses

Biological activity of the aqueous extract of Lychnophora pinaster Mart

Lyophilized aqueous extract (LAE) from Lychnophora pinaster Mart (Asteraceae) aerial parts was evaluated in the search of possible biological activities. LAE exhibited trypanocidal activity (113.62 μg/mL), but could not inhibit 5-lipoxygenase in vitro (17% of inhibition). LAE chemical characterization by HPLC with UV-Diode Array Detector showed the presence of caffeic acid, isochlorogenic acid, vitexin, isovitexin and quercetin, in comparison with authentic samples

Safety and health index development for formulated product design: Paint formulation

Over the years, safety and health effects among consumers due to the exposure of formulated products have been reported. Thus, there is a need for systematic methodologies to assess the safety and health effects of the candidate’s ingredients in the early stages of formulated product design. Therefore, an index-based methodology was proposed to assess the safety and health effects in formulated product design. Product Safety and Health Index (PSHI) highlights the health sub-indexes based on the exposure routes including eye, inhalation, ingestion, and dermal. Each exposure route has its corresponding health sub-indexes that have to be applied. There are also new sub-indexes introduced for ingestion and dermal exposure. A case study on paint formulation was used to illustrate the developed methodology. The results show that the newly proposed index is able to identify hazardous chemical ingredient(s) with its corresponding adverse safety and health effects

An experimental protocol for mimicking pathomechanisms of traumatic brain injury in mice

Traumatic brain injury (TBI) is a result of an outside force causing immediate mechanical disruption of brain tissue and delayed pathogenic events. In order to examine injury processes associated with TBI, a number of rodent models to induce brain trauma have been described. However, none of these models covers the entire spectrum of events that might occur in TBI. Here we provide a thorough methodological description of a straightforward closed head weight drop mouse model to assess brain injuries close to the clinical conditions of human TBI

Decreased Levels of Soluble CD44 in a High-Risk Population following a Smoking Cessation Program

Tobacco is a risk factor of head and neck cancer (HNC) and smoking cessation alone may reduce HNC risk by 70%. Soluble CD44 (solCD44), a cell surface receptor linked to cell proliferation and migration, and total protein (TP) levels can detect early HNC. This study aims to determine whether salivary solCD44 and TP levels in oral rinses change following a smoking cessation program. 150 smokers provided oral rinse samples at baseline and at a 12-month follow-up after participation in a smoking cessation program. Assays to measure levels of solCD44, TP, and cotinine, a metabolite used as a biomarker of tobacco exposure, were completed. A paired-samples t-test was used to determine whether there was a statistically significant ( \u3c 0.05) mean difference in biomarker levels before and after the program. Baseline and at 12-month follow-up data were available for 88 subjects, 21 of whom quit smoking entirely. Mean levels of solCD44 significantly decreased by 0.412 ng/mL from baseline to the 12-month follow-up, = 0.010. There was no significant difference in mean TP levels, = 0.975. Mean cotinine levels decreased significantly by 74.7 ng/mL, = 0.035. This is the first work demonstrating an association between smoking cessation and decreased solCD44 levels in oral rinses. Decreased expression of the tumorigenic CD44 may be one mechanism by which smoking cessation lowers cancer risk