Liberal governmentality in Spain: bodies, minds, and the medical construction of the “outsider,” 1870–1910

This paper traces the fragility of the subject in the period extending from the aftermath of the Sexenio through to the early twentieth century. In particular, two case studies are focused upon: the question of gender “deviance” and the figure of the genius, in order to understand how medicine participated in the construction of “outsider” identities within the context of the emerging liberal order. How did liberal rationales exclude or curtail certain wayward expressions of identity and subjectivity? What consequences did the marking of “excessive” figures or outsiders have for notions of inclusiveness and citizenship within the late-nineteenth-century liberal order? By concentrating primarily on medical texts and journals published during the period, this study builds on existing research to tease out answers to these questions

Quantitative proteomics combined with BAC TransgeneOmics reveals in vivo protein interactions

QUBIC, a specific and highly sensitive method for detection of protein–protein interactions, is used to identify new partners for the mitotic spindle components pericentrin and TACC3

Case-case-control study on factors associated with vanB vancomycin-resistant and vancomycin-susceptible enterococcal bacteraemia

BACKGROUND: Enterococci are a major cause of healthcare-associated infection. In Australia, vanB vancomycin-resistant enterococci (VRE) is the predominant genotype. There are limited data on the factors linked to vanB VRE bacteraemia. This study aimed to identify factors associated with vanB VRE bacteraemia, and compare them with those for vancomycin-susceptible enterococci (VSE) bacteraemia. METHODS: A case-case-control study was performed in two tertiary public hospitals in Victoria, Australia. VRE and VSE bacteraemia cases were compared with controls without evidence of enterococcal bacteraemia, but may have had infections due to other pathogens. RESULTS: All VRE isolates had vanB genotype. Factors associated with vanB VRE bacteraemia were urinary catheter use within the last 30 days (OR 2.86, 95% CI 1.09-7.53), an increase in duration of metronidazole therapy (OR 1.65, 95% CI 1.17-2.33), and a higher Chronic Disease Score specific for VRE (OR 1.70, 95% CI 1.05-2.77). Factors linked to VSE bacteraemia were a history of gastrointestinal disease (OR 2.29, 95% CI 1.05-4.99) and an increase in duration of metronidazole therapy (OR 1.23, 95% CI 1.02-1.48). Admission into the haematology/oncology unit was associated with lower odds of VSE bacteraemia (OR 0.08, 95% CI 0.01-0.74). CONCLUSIONS: This is the largest case-case-control study involving vanB VRE bacteraemia. Factors associated with the development of vanB VRE bacteraemia were different to those of VSE bacteraemia

Plk1 regulates mitotic Aurora A function through βTrCP-dependent degradation of hBora

Polo-like kinase 1 (Plk1) and Aurora A play key roles in centrosome maturation, spindle assembly, and chromosome segregation during cell division. Here we show that the functions of these kinases during early mitosis are coordinated through Bora, a partner of Aurora A first identified in Drosophila. Depletion of human Bora (hBora) results in spindle defects, accompanied by increased spindle recruitment of Aurora A and its partner TPX2. Conversely, hBora overexpression induces mislocalization of Aurora A and monopolar spindle formation, reminiscent of the phenotype seen in Plk1-depleted cells. Indeed, Plk1 regulates hBora. Following Cdk1-dependent recruitment, Plk1 triggers hBora destruction by phosphorylating a recognition site for \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\text{SCF}}^{{\text{ $ \beta $ - TrCP}}}$$\end{document}. Plk1 depletion or inhibition results in a massive accumulation of hBora, concomitant with displacement of Aurora A from spindle poles and impaired centrosome maturation, but remarkably, co-depletion of hBora partially restores Aurora A localization and bipolar spindle formation. This suggests that Plk1 controls Aurora A localization and function by regulating cellular levels of hBora

La enseñanza del derecho en el siglo XX: Homenaje a Mariano Peset

Este libro cierra el tracto que se inició, en octubre de 2002 con la investidura como doctor honoris causa del profesor Mariano Peset. El hecho de que la historia de las universidades haya sido una línea ininterrumpida a lo largo de su investigación y el que hayamos tratado de materializar sus enseñanzas de tantos años en el Instituto Antonio de Nebrija de Estudios sobre la Universidad explican que le hayamos dedicado este homenaje científico en un seminario que tuvo lugar en el campus de Colmenarejo de la Universidad Carlos III durante los días 22 y 23 de septiembre de 2003. Quisimos que el encuentro científico tuviera carácter monográfico, para centrar el interés de nuestro encuentro y evitar la dispersión de los discursos. Y pensamos que tratar de la enseñanza del derecho en el siglo XX era un buen tema por varias razones, entre las que subrayo dos: porque la centuria pasada ya puede ser tratada históricamente y, sobre todo, para continuar la labor de Mariano Peset que, en su día, hizo lo propio para el siglo XIX, con incursiones también en el que nos ocupa en este libro.Prólogo / Adela Mora Cañada. -- La enseñanza de la historia del derecho y la LRU / Ramon Aznar i Garcia y Manuel Martínez Neira. -- Vicente Santamaría de Paredes, político y administrativista / Yolanda Blasco Gil. -- La enseñanza del Derecho en Valencia durante la autonomía de César Silió (1919-1921) / Daniel Comas Caraballo. -- Críticas a la codificación foral prevista en el código civil a la luz de la doctrina jurídico-civil contemporánea / Manuel Vicente Febrer Romaguera. -- La Facultad de Derecho de Valencia en el primer tercio del siglo xx (1900-1938) / Jorge Correa y Fco. Javier Palao. -- La política desde una asignatura: el Derecho Natural / Eusebio Fernández García. -- La institución del Senado en los catedráticos de Derecho Político (1900-1940) / Pilar García Trobat. -- Catedráticos de derecho en la Asamblea Nacional Consultiva de 1927 / María Pilar Hernando Serra. -- El Derecho político en Valencia, con especial referencia a Mariano Gómez González (1915-1932) / M.ª Fernanda Mancebo. -- Fe católica y razón liberal en el Derecho político. La anónima relevancia de Juan de Dios Vico y Brabo (1845-1908) / Sebastián Martín. -- Una polémica profesional: catedráticos y magistrados durante la II República / Pascual Marzal Rodríguez. -- Centro y periferia: el Doctorado en Derecho durante el siglo XX / Antonio Merchán. -- La irrupción de nuevos sectores: el Derecho Laboral / Miguel C. Rodríguez-Piñero Royo. -- El trabajo de cátedra de Adolfo Posada / Mónica Soria. -- Sobre los inicios en la enseñanza del Derecho del Trabajo / Carlos Tormo Camallonga. -- La enseñanza del mercantil a principios del siglo XX. El manual de Lorenzo Benito y Endara / Sergio Villamarín Gómez. – Clausura / Mariano Pese

Genetic Diversity among Enterococcus faecalis

Enterococcus faecalis, a ubiquitous member of mammalian gastrointestinal flora, is a leading cause of nosocomial infections and a growing public health concern. The enterococci responsible for these infections are often resistant to multiple antibiotics and have become notorious for their ability to acquire and disseminate antibiotic resistances. In the current study, we examined genetic relationships among 106 strains of E. faecalis isolated over the past 100 years, including strains identified for their diversity and used historically for serotyping, strains that have been adapted for laboratory use, and isolates from previously described E. faecalis infection outbreaks. This collection also includes isolates first characterized as having novel plasmids, virulence traits, antibiotic resistances, and pathogenicity island (PAI) components. We evaluated variation in factors contributing to pathogenicity, including toxin production, antibiotic resistance, polymorphism in the capsule (cps) operon, pathogenicity island (PAI) gene content, and other accessory factors. This information was correlated with multi-locus sequence typing (MLST) data, which was used to define genetic lineages. Our findings show that virulence and antibiotic resistance traits can be found within many diverse lineages of E. faecalis. However, lineages have emerged that have caused infection outbreaks globally, in which several new antibiotic resistances have entered the species, and in which virulence traits have converged. Comparing genomic hybridization profiles, using a microarray, of strains identified by MLST as spanning the diversity of the species, allowed us to identify the core E. faecalis genome as consisting of an estimated 2057 unique genes

Electroweak resummation of neutralino dark-matter annihilation into high-energy photons

Abstract We consider the resummation of large electroweak Sudakov logarithms for the annihilation of neutralino DM with (TeV) mass to high-energy photons in the minimal supersymmetric standard model, extending previous work on the minimal wino and Higgsino models. We find that NLL resummation reduces the yield of photons by about 20% for Higgsino-dominated DM at masses around 1 TeV, and up to 45% for neutralinos with larger wino admixture at heavier masses near 3 TeV. This sizable effect is relevant when observations or exclusion limits are translated into MSSM parameter-space constraints

A low-cost and low-power multi-standard video encoder

Video encoders are an important IP block in mobile multimedia systems. In this paper, we describe a low-cost low-power multi-standard (MPEG4, JPEG, and H.263) video/image encoder. The low-cost and low-power aspects are achieved by the right choice of algorithms and architectures. In the algorithm front, an embedded compression technique for reducing the size of loop memory has enabled a single-chip low-cost realization of the encoder. In the architectural front, an efficient hardware-software partitioning has contributed to the design of a low-power encoder. Further, the hardware components that accelerate the kernels of encoding are implemented as application specific instruction-set processors (ASIPs) thereby providing flexibility to address multi-standard encoding. The power and area estimates for the encoder fo